Der Onkologe

, Volume 19, Issue 1, pp 44–51

Zervikales CUP-Syndrom

  • C. Mozet
  • G. Wichmann
  • P. Stumpp
  • S. Dietzsch
  • A. Dietz
Leitthema

Zusammenfassung

Wenn bei Auftreten von Lymphknotenmetastasen die Primärtumorlokalisation durch die initialen diagnostischen Schritte verborgen bleibt, spricht man von „cancer of unknown primary“ (CUP-Syndrom). Diese Manifestationsform betrifft 4–5% aller humanen Malignome und liegt damit unter den 10 häufigsten Krebsarten. Wenn der Primärtumor durch erweiterte Diagnostik schließlich detektiert wird, liegt ein initiales CUP-Syndrom vor, sonst spricht man von einem echten CUP-Syndrom. Die häufigsten CUP-Metastasen sind Adenokarzinome, gefolgt von schlecht differenzierten Karzinomen, Plattenepithelkarzinomen und neuroendokrinen Tumoren. Halslymphknotenmetastasen unbekannten Ursprungs haben generell eine schlechtere Prognose als die meisten Kopf-Hals-Tumoren, was aber von einer Reihe von Einflussfaktoren abhängt. Dieser Beitrag stellt moderne diagnostische Schritte wie PET-CT/MRT vor und erörtert die therapeutischen Optionen und die Prognose der Patienten mit einem zervikalen CUP-Syndrom.

Schlüsselwörter

„Cancer of unknown primary“ Kopf-Hals-Tumoren Metastasen Adenokarzinome Plattenepithelkarzinome 

Cervical CUP syndrome

Abstract

Whenever the first diagnosis of a solid malignancy is found in lymphoid tissue and detection of the primary tumor during the initial diagnostic procedures is not successful, this syndrome is called CUP (cancer of unknown primary). When extensive diagnostic steps finally lead to detection of the primary, then an initial cup syndrome can be assumed in contrast to true CUP syndromes, where the primary tumor remains unrevealed. Most CUP metastases are adenocarcinomas, followed by poorly differentiated carcinomas, squamous cell carcinomas, and neuroendocrine tumors. Metastasis of unknown primaries occurring in lymph nodes of the neck region have a poor prognosis and is predominantly associated with worse prognosis than most other head and neck tumors, which however does depend on various factors. In this article, we introduce diagnostic steps with modern techniques like PET-CT/MRI, and review therapeutic options and prognosis in patients with cervical CUP syndrome.

Keywords

Cancer of unknown primary Head and neck tumors Metastasis Adenocarcinomas Squamous cell carcinomas 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • C. Mozet
    • 1
  • G. Wichmann
    • 1
  • P. Stumpp
    • 2
  • S. Dietzsch
    • 3
  • A. Dietz
    • 1
  1. 1.Klinik und Poliklinik für Hals-Nasen- und OhrenheilkundeUniversität LeipzigLeipzigDeutschland
  2. 2.Klinik und Poliklinik für Diagnostische und Interventionelle RadiologieUniversität LeipzigLeipzigDeutschland
  3. 3.Klinik für StrahlentherapieUniversität LeipzigLeipzigDeutschland

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