Der Onkologe

, Volume 14, Issue 2, pp 191–197 | Cite as

Differenzialtherapie beim metastasierenden Nierenzellkarzinom

Aktuelle Therapie

Zusammenfassung

Im Jahr 2006 wurden Sorafenib und Sunitinib in Europa für die Behandlung von metastasierenden Nierenzellkarzinomen (mNZK) zugelassen. Weitere innovative Substanzen, über die noch keine Daten veröffentlicht wurden, sind auf dem Markt zu erwarten. Sie werden eine ganze Palette individueller therapeutischer Optionen ermöglichen. Die Grundlagen der primären chirurgischen Verfahren zur Tumor- und Metastasenresektion bleiben hierbei unberührt. Da ein anerkannter Algorithmus für diese neue Medikamentenklasse bisher fehlt, werden Empfehlungen zur mNZK-Therapie in der klinischen Praxis notwendig. Der vorgestellte Behandlungsalgorithmus basiert auf Ergebnissen der evidenzbasierten Medizin in Verbindung mit Parametern, die sich aus den im Jahr 2007 beim ASCO-Kongress vorgestellten Daten ergeben haben – und letztendlich auf breiten Erfahrungen bei der Behandlung von mNZK-Patienten.

Schlüsselwörter

Nierenzellkarzinom Targeted therapy Kinaseinhibitoren Chemo-/Immuntherapie Therapiealgorithmus 

Treatment optimization in metastatic renal cell carcinoma

Abstract

In 2006 the new compounds Sorafenib and Sunitinib were approved in Europe for the treatment of advanced renal cell carcinoma (mRCC). Additional innovative substances are to be expected on the market for which data have not yet been published and will provide physicians with a whole array of individual therapeutic options. Principles of primary surgical procedures for tumor and metastasis resection remain untouched. An accepted algorithm for the new drug entities has, however, been missing and it is felt that recommendations on how mRCC should be treated in clinical practice are needed. The suggested treatment algorithm is based on results from evidence-based medicine together with parameters which resulted in the approval of recent data announced at the ASCO congress in 2007 and, last but not least, on wide experience in treating mRCC patients.

Keywords

Renal cell cancer Targeted therapy Kinase inhibitors Chemotherapy Immunotherapy Treatment algorithm 

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Copyright information

© Springer Medizin Verlag 2008

Authors and Affiliations

  • H. Kirchner
    • 1
  • H. Heinzer
    • 2
  • J. Roigas
    • 3
  • F. Overkamp
    • 4
  1. 1.Klinikum Region Hannover GmbHKrankenhaus Siloah, Medizinische Klinik IIIHannoverDeutschland
  2. 2.Klinik und Poliklinik für Urologie, UKEHamburgDeutschland
  3. 3.Urologische KlinikCharite – Universitätsmedizin Berlin, Campus Benjamin FranklinBerlinDeutschland
  4. 4.Praxis und Tagesklinik für Internistische OnkologieRecklinghausenDeutschland

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