Der Onkologe

, Volume 13, Issue 5, pp 427–433 | Cite as

Hochdosistherapie bei malignen Lymphomen

Eine Standortbestimmung
Leitthema
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Zusammenfassung

Hochdosistherapie (HDT) und autologe Transplantation von Blut bildenden Stammzellen sind wichtig in der Behandlung von Lymphompatienten. Daten der European Group for Blood and Marrow Transplantation (EBMT) belegen eine steigende Häufigkeit sowohl von autologen als auch von allogenen Transplantationen bei den meisten Untergruppen der Lymphome. In Anbetracht der neuen Entwicklungen der herkömmlichen Therapie, insbesondere der immer häufigeren Anwendung des monoklonen Anti-CD20-Antikörpers Rituximab sowie des Einsatzes dosisreduzierter Konditionierung vor allogener Transplantation, ist eine Neuabschätzung von HDT und Stammzellentransplantation indiziert, damit die Rolle dieser Modalität im Jahr 2006 neu definiert werden kann.

Schlüsselwörter

Hochdosistherapie Autologe Transplantation Morbus Hodgkin Follikuläres Lymphom Aggressives Lymphom 

High-dose therapy in malignant lymphomas

The status quo

Abstract

High-dose therapy (HDT) and autologous transplantation of hematopoietic stem cells are important in the treatment of patients with lymphoma. Data from the European Group for Blood and Marrow Transplantation (EBMT) document increasing numbers of autologous and allogeneic transplants for most lymphoma subtypes. Recent developments in conventional therapy, in particular the ever-increasing use of the monoclonal anti-CD20 antibody rituximab well as the incremental use of reduced-intensity conditioning prior to allogeneic transplantation call for a re-evaluation of HDT and stem cell transplantation to allow the role of these modalities to be freshly defined in 2006.

Keywords

High-dose therapy Autologous transplantation Hodgkin’s disease Follicular lymphoma Aggressive lyphoma 

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Copyright information

© Springer Medizin Verlag 2007

Authors and Affiliations

  1. 1.Abt. HämatologieAsklepios Klinik St. GeorgHamburgDeutschland
  2. 2.Hospital de la Santa Creu i Sant Pau, Barcelona-España

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