Der Onkologe

, Volume 12, Issue 10, pp 1003–1011 | Cite as

Diagnostik und Therapie der akuten myeloischen Leukämie des Erwachsenen

Leitthema

Zusammenfassung

Das Verständnis der Biologie der akuten myeloischen Leukämie (AML) hat sich in den letzten Jahren deutlich verbessert. Dies macht den Einsatz komplexer diagnostischer Verfahren und die Einführung neuer Klassifikationssysteme notwendig. Gleichzeitig ergeben sich Möglichkeiten für risikoadaptierte bzw. subgruppenspezifische Therapiestrategien. Neue Prognosefaktoren und Therapieverfahren führen zu einer nicht unerheblichen Verunsicherung bei der Behandlung der AML im klinischen Alltag. Der vorliegende Beitrag gibt deshalb eine Übersicht über moderne Diagnoseverfahren, neue Prognosefaktoren und die aktuelle prognostische Einteilung der AML. Weiterhin werden die etablierten Therapiestrategien dargestellt und im Kontext der aktuellen Literatur bewertet. Zuletzt werden neue Therapieansätze und deren Perspektiven aufgezeigt.

Schlüsselwörter

Akute myeloische Leukämie Erwachsene Diagnostik Therapie Prognostische Faktoren 

Diagnostic work-up and treatment of acute myeloid leukemia in adults

Abstract

In recent years knowledge about the biology of acute myeloid leukemia has improved tremendously. This has led to the necessity of using complex diagnostic procedures and introducing new classification systems. In parallel possibilities evolved for risk-adapted or specific therapeutic strategies within subgroups of the disease. New prognostic factors and therapeutic options led to significant confusion regarding the day-to-day routine in AML therapy. The report presented here gives an overview of modern diagnostic procedures, new prognostic factors, and up-to-date prognostic classification systems in AML. Furthermore, established therapeutic strategies are described and discussed in the context of the most recent literature. Finally, new therapeutic possibilities and their perspectives for the future are highlighted.

Keywords

Acute myeloid leukemia Adults Diagnostics Therapy Prognostic factors 

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Copyright information

© Springer Medizin Verlag 2006

Authors and Affiliations

  1. 1.Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav CarusDresdenDeutschland

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