Der Onkologe

, Volume 11, Issue 9, pp 933–941 | Cite as

Behandlung mittlerer Stadien beim Hodgkin-Lymphom

Leitthema

Zusammenfassung

In der DHSG werden die meisten Patienten in klinischem Stadium I und II mit spezifischen Risikofaktoren der Gruppe der mittleren (intermediären) Stadien zugeordnet. Die Standardtherapie besteht in der Regel aus einer kombinierten Radiochemotherapie mit 4 Zyklen ABVD und 30 Gy Involved-Field-Strahlentherapie. Aktuell wird in klinischen Studien geprüft, ob durch weitere Intensivierung der Chemotherapie das Outcome bezüglich der Rezidivrate und des Gesamtüberleben verbessert werden kann: Für Patienten unter 60 Jahre wird das BEACOPP-eskaliert-Schema in die Behandlung der mittleren Stadien eingeführt (HD14-Studie der DHSG). Für Patienten über 60 wird das sog. BACOPP-Schema im Rahmen einer neuen Phase-II-Studie evaluiert.

Schlüsselwörter

Hodgkin-Lymphom Intermediäre Stadien Risikofaktoren Chemotherapie Involved-Field-Strahlentherapie 

Treatment of early unfavorable stages

Abstract

In the GHSH, most patients who present clinical stage I or II with certain risk factors are allocated to the early-stage unfavorable (intermediate) group. The standard therapy usually consists of combined modality treatment including four cycles of ABVD followed by 30 Gy of involved-field radiotherapy. Currently, clinical trials investigate whether a further intensification of chemotherapy can improve outcome in terms of both relapses and overall survival. For patients below the age of 60 years, the BEACOPP escalated regimen is being introduced in the treatment of early-unfavorable stages (HD14 trial of the GHSG). For patients above the age of 60, the BACOPP regimen is being evaluated in a new phase II study.

Keywords

Hodgkin’s lymphoma Early-stage unfavorable Risk factors Chemotherapy Involved-field radiotherapy 

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Copyright information

© Springer Medizin Verlag 2005

Authors and Affiliations

  1. 1.Klinik I für Innere Medizin/DHSG, Universitätsklinikum Köln
  2. 2.Klinik I für Innere Medizin, DHSG-Studienzentrale, Universitätsklinikum KölnKöln

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