Archives of Women's Mental Health

, Volume 2, Issue 3, pp 97–105 | Cite as

Progesterone, GABA and mood disorders in women

  • A. J. Rapkin
Review article


The hormone progesterone fluctuates widely across the menstrual cycle, postpartum, and in the climacteric. Progesterone and the 5α 3α reduced metabolites of progesterone have been termed neurosteroids because they are synthesized in the central nervous system and affect neurologic functioning, and therefore, mood and behavior.

Further study of the relationship of progesterone, allopregnanolone and other progesterone metabolites to the premenstrual dysphoric disorder, anxiety, and depressive disorders is warranted.

Keywords: Progesterone; progesterone metabolites; allopregnanolone; mood. 


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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • A. J. Rapkin
    • 1
  1. 1.Department of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, U.S.A.US

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