Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

  • Jodi L. PawluskiEmail author
  • Ursula Brain
  • Geoffrey L. Hammond
  • Tim F. Oberlander
Short Communication
Part of the following topical collections:
  1. Neurobiology of Maternal Mental Illness


The effect of perinatal selective serotonin reuptake inhibitors (SSRIs) on brain-derived neurotrophic factor (BDNF) and S100 calcium binding protein B (S100B) has not been investigated. Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. This shows that serum S100B could be a unique biomarker to determine efficacy of SSRIs during gestation.


Depression Anxiety Antidepressants Gestation Motherhood Neuroplasticity 


Compliance with ethical standards

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)University RennesRennesFrance
  2. 2.Department of Pediatrics, BC Children’s HospitalThe University of British ColumbiaVancouverCanada
  3. 3.Department of Cellular and Physiological Sciences, Faculty of MedicineThe University of British ColumbiaVancouverCanada

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