Is depression more likely following childbirth? A population-based study
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Postpartum depression (PPD) is characterized as a depressive episode conditional on childbirth. We examined whether the risk of depression is higher following childbirth than that at a randomly generated time unrelated to childbirth. In a prospective cohort of all women with live singleton births in Sweden, 1997–2008, we first calculated the relative risk (RR) of PPD for mothers with a history of depression compared to mothers without such a history. Next, we repeated the calculations, but now for depression following a computer-generated arbitrary “phantom delivery” date, unrelated to the true date of delivery. For this phantom delivery date, we used the average expected date of delivery for all women of the same age. For the analyses of each group, women were followed for a full calendar year. We fitted Poisson regression and calculated RR and two-sided 95% confidence intervals (CI). Among a total of 707,701 deliveries, there were 4397 PPD cases and 4687 control depression cases. The RR of PPD was 21.0 (CI 19.7–22.4). The RR of depression in the control group was 26.2 (CI 24.7–27.9). We provide evidence that the risk for PPD is no greater following childbirth than following a random date unrelated to childbirth. This finding suggests that the postpartum period may not necessarily represent a time of heightened vulnerability for clinically significant depression and that the well-established observation of depression covarying with childbirth does not necessarily equate to causation, but rather may be a secondary effect of postpartum women representing a medically captured population.
KeywordsEpidemiology Depression Postpartum depression (PPD) Diagnosis
This study was supported by a grant to Michael E. Silverman from the Eunice Kennedy Shriver National Institute of Child Health and Human Development; Grant number: R21HD073010.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.
- Gaynes BN, Gavin N, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G, Brody S, Miller WC (2005). Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evidence Report/Technology Assessment No. 119. (Prepared by the RTI-University of North Carolina Evidence-based Practice Center, under Contract No. 290–02-0016.) AHRQ Publication No. 05-E006–2. Rockville, MD: Agency for Healthcare Research and QualityGoogle Scholar
- Hoertel N, López S, Peyre H, Wall MM, González-Pinto A, Limosin F, Blanco C (2015) Are symptom features of depression during pregnancy, the postpartum period and outside the peripartum period distinct? Results from a nationally representative sample using item response theory (IRT). Depress Anxiety 32(2):129–140CrossRefPubMedGoogle Scholar
- Myers ER, Aubuchon-Endsley N, Bastian LA, Gierisch JM, Kemper AR, Swamy GK et al (2013) Efficacy and safety of screening for postpartum depression. Comparative Effectiveness Review 106. AHRQ Publication No. 13-EHC064-EF. Agency for Healthcare Research and Quality, RockvilleGoogle Scholar
- Wisner KL, Sit DK, McShea MC, Rizzo DM, Zoretich RA, Hughes CL, Eng HF, Luther JF, Wisniewski SR, Costantino ML, Confer AL, Moses-Kolko EL, Famy CS, Hanusa BH (2013) Onset timing, thoughts of self-harm, and diagnoses in postpartum women with screen-positive depression findings. JAMA Psychiatry 70(5):490–498CrossRefPubMedPubMedCentralGoogle Scholar
- World Health Organization (1992) International statistical classification of diseases and related health problems, 10th revision (ICD-10). WHO, GenevaGoogle Scholar