Archives of Women's Mental Health

, Volume 19, Issue 5, pp 789–797 | Cite as

Cortisol response to the Trier Social Stress Test in pregnant women at risk for postpartum depression

  • Kristina M. Deligiannidis
  • Aimee R. Kroll-Desrosiers
  • Abby Svenson
  • Nina Jaitly
  • Bruce A. Barton
  • Janet E. Hall
  • Anthony J. Rothschild
Original Article

Abstract

Antepartum depression and anxiety are risk factors for postpartum depression (PPD). Postpartum abnormalities in hypothalamic-pituitary-adrenal (HPA) reactivity are associated with PPD. It is not known if antepartum HPA abnormalities exist in women at risk for PPD (AR-PPD). We measured salivary cortisol response to the Trier Social Stress Test (TSST) in 44 (24 AR-PPD, 20 healthy comparison) pregnant women. Depression and anxiety were measured using the Edinburgh Postnatal Depression Scale (EPDS) and Spielberger State-Trait Anxiety Inventory-State (STAI-S). We analyzed longitudinal changes in cortisol using generalized estimating equation methods to control for the correlation within subjects at the six TSST time points. Group differences in area under the curve (AUC) were examined. A majority (70.8 %) of the AR-PPD had prior depression. EPDS total score was higher in AR-PPD vs. comparison women (mean EPDS = 9.8 ± 4.9 vs. mean EPDS = 2.4 ± 2.0 respectively, p < 0.001). Mean STAI-S total score was higher in AR-PPD vs. comparison women at all TSST time points and over time (z = 2.71, df = 1, p = 0.007). There was no significant difference in cortisol concentration over time between groups. We observed no detectable difference in cortisol response to psychosocial stress induced by the TSST despite clinically significant between-group differences in current/past depression and current symptomatology.

Keywords

Postpartum Cortisol Depression Anxiety 

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  1. 1.Center for Psychopharmacologic Research and Treatment, Department of PsychiatryUniversity of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Women’s Mental Health Program, Departments of Psychiatry and Obstetrics and GynecologyUniversity of Massachusetts Medical School, UMass Memorial Medical CenterWorcesterUSA
  3. 3.Department of Quantitative Health SciencesUniversity of Massachusetts Medical SchoolWorcesterUSA
  4. 4.National Institute of Environmental Health Sciences, National Institutes of HealthResearch Triangle ParkUSA
  5. 5.Reproductive Endocrine UnitMassachusetts General Hospital/Harvard Medical SchoolBostonUSA

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