Metformine for psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome

  • Christina AndreouEmail author
  • Markos Syngelakis
  • Athanasios Karavatos
Letter to the Editor


There are several reports of periodic psychotic disorders that appear in connection with the various phases of the menstrual cycle. Although the pathogenesis of menstrual psychosis has not been systematically investigated, it appears that it might be linked to an estrogen cascade that follows a period of sustained high estrogen levels, as in the case in anovulatory cycles. We present a case of psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome, a disorder typically characterized by anovulatory cycles, in whom the restoration of normal menstruation with use of metformine led to significant improvement of psychotic symptoms.


Menstrual psychosis Puerperal psychosis Anovulatory cycles Polycystic ovary syndrome Metformine 


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Christina Andreou
    • 1
    • 2
    Email author
  • Markos Syngelakis
    • 1
  • Athanasios Karavatos
    • 1
  1. 1.1st Psychiatric DepartmentAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Hellenic Center for Mental Health and ResearchThessalonikiGreece

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