Archives of Women's Mental Health

, Volume 10, Issue 4, pp 147–153 | Cite as

Stable serum levels of relaxin throughout the menstrual cycle: a preliminary comparison of women with premenstrual dysphoria and controls

  • M. Pehrsson
  • L. Westberg
  • M. Landén
  • A. Ekman
Original contribution


Serum levels of relaxin in 25 women with premenstrual dysphoria and 25 age-matched controls were determined at three time points during the menstrual cycle. At the same time, levels of estradiol, progesterone, 17-β-OH-progesterone, free testosterone, total testosterone, sex hormone binding hormone, androstenedione, dehydroepiandrosterone sulphate, and 3-α-androstanediol glucuronide were determined. Detectable levels of relaxin were found in all women in both the follicular and luteal phase as well as around ovulation, the inter-individual variations being larger than intra-individual differences. The levels of relaxin were not influenced by the fluctuation of the other reproductive hormones. A significant difference between the two groups of women was observed, subjects with premenstrual dysphoria displaying reduced levels of relaxin (p < 0.05) compared to controls. Also, when analysed with respect to a variable number of tandem repeats polymorphism (CT repeats followed by GT repeats) in the promotor region of the relaxin H2 gene, women with premenstrual dysphoria (n = 29) were found to display significantly longer GT repeats than controls (n = 35).

Keywords: Relaxin; premenstrual dysphoria; dinucleotide repeat; GT microsatellite; relaxin H2 gene 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • M. Pehrsson
    • 1
  • L. Westberg
    • 1
  • M. Landén
    • 2
  • A. Ekman
    • 1
  1. 1.Department of Neuroscience and Physiology, Section of PharmacologyGöteborg UniversityGöteborgSweden
  2. 2.Department of Clinical Neuroscience, Section of Psychiatry S:t GöranKarolinska InstitutetStockholmSweden

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