Stable serum levels of relaxin throughout the menstrual cycle: a preliminary comparison of women with premenstrual dysphoria and controls
- 106 Downloads
Serum levels of relaxin in 25 women with premenstrual dysphoria and 25 age-matched controls were determined at three time points during the menstrual cycle. At the same time, levels of estradiol, progesterone, 17-β-OH-progesterone, free testosterone, total testosterone, sex hormone binding hormone, androstenedione, dehydroepiandrosterone sulphate, and 3-α-androstanediol glucuronide were determined. Detectable levels of relaxin were found in all women in both the follicular and luteal phase as well as around ovulation, the inter-individual variations being larger than intra-individual differences. The levels of relaxin were not influenced by the fluctuation of the other reproductive hormones. A significant difference between the two groups of women was observed, subjects with premenstrual dysphoria displaying reduced levels of relaxin (p < 0.05) compared to controls. Also, when analysed with respect to a variable number of tandem repeats polymorphism (CT repeats followed by GT repeats) in the promotor region of the relaxin H2 gene, women with premenstrual dysphoria (n = 29) were found to display significantly longer GT repeats than controls (n = 35).
Unable to display preview. Download preview PDF.
- American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV), Washington, DCGoogle Scholar
- Armbruster, FP, Grön, H-J, Maier, I, Becker, S, Bailer, SM, Lippert, TH, Seeger, H, Klöppinger, M, Tampe, J, Stoeva, S, Voelter, W 2001A sensitive homologous radioimmunoassay for human relaxin-2 (H-RLX-2) based on antibodies charactarized by epitope mapping studiesEur Med Res619Google Scholar
- Gao, PS, Heller, NM, Walker, W, Chen, CH, Moller, M, Plunkett, B, Roberts, MH, Schleimer, RP, Hopkin, JM, Huang, SK 2004Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitroJ Med Genet41535569PubMedCrossRefGoogle Scholar
- Heringlake, M, Heide, C, Bahlman, L, Eichler, W, Pagel, H, Schmucker, P, Wergeland, R, Armbruster, FP, Klaus, S 2004The effects of tilting and volume-loading on plasma levels and urinary excretion of relaxin, NTproANP, and NTproBNP in male volunteersJ Appl Physiol97173179PubMedCrossRefGoogle Scholar
- Itokawa, M, Yamada, K, Yoshitsugu, K, Toyota, T, Suga, T, Ohba, H, Watanabe, A, Hattori, E, Shimizu, H, Kumakura, T, Ebihara, M, Meerabux, JM, Toru, M, Yoshikawa, T 2004A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophreniaPharmacogenetics13271278CrossRefGoogle Scholar
- Ma, S, Shen, PJ, Burazin, TC, Tregear, GW, Gundlach, AL 2006Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: restricted somatic co-expression a clue to relaxin action?Neuroscience141329344PubMedCrossRefGoogle Scholar
- Maier I, Grön H-J, Dschietzig T, Stangle K, Echner H, Voelter W, Lippert TH, Seeger H, Armbruster FP (2000) A highly sensitive homologous human relaxin ELISA. 3rd International Conference on relaxin and related peptides, Broome, Australia, P-05Google Scholar
- Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R, Dunbar, GC 1998The Mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10J Clin Psychiatry592233quiz 34–57PubMedGoogle Scholar
- Sherwood, OD 1994RelaxinKnobil, ENeil, J eds. The physiology of reproductionRaven PressNew York8611009Google Scholar