Archives of Women's Mental Health

, Volume 10, Issue 3, pp 125–127 | Cite as

Symptom-onset dosing with citalopram in the treatment of premenstrual dysphoric disorder (PMDD): a case series

  • L. N. Ravindran
  • S.-A. Woods
  • M. Steiner
  • A. V. Ravindran
Short communication


The efficacy and tolerability of symptom-onset dosing with citalopram in the treatment of premenstrual dysphoric disorder (PMDD) was evaluated in an open trial. Eight outpatients, aged 18–45 years and diagnosed with PMDD, were treated with 10–20 mg of citalopram from the start of premenstrual symptoms until the onset of menses. Primary efficacy variables were the premenstrual tension scale (PMTS-O) and the clinical global impression of improvement (CGI). Treatment was associated with significant improvement in PMDD symptoms (p < 0.001).

Keywords: Citalopram; premenstrual dysphoric disorder; psychopharmacology; symptom-onset dosing. 


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  1. Freeman, EW 2004Luteal phase administration of agents for the treatment of premenstrual dysphoric disorderCNS Drugs18453468PubMedCrossRefGoogle Scholar
  2. Freeman, EW, Sondheimer, SJ, Sammel, MD, Ferdousi, T, Lin, H 2005A preliminary study of luteal phase versus symptom-onset dosing with escitalopram for premenstrual dysphoric disorderJ Clin Psych66769773CrossRefGoogle Scholar
  3. Guy W (1976) ECDEU assessment of manual for psychopharmacology. NIMH Public Department of Health, Education and Human Welfare Publication NO. (Adm.) 76–338 (Revised). Rockvill MA, pp 217–222.Google Scholar
  4. Kornstein, SG, Pearlstein, TB, Fayyad, R, Farfel, GM, Gillespie, JA 2006Low-dose sertraline in the treatment of moderate-to-severe premenstrual syndrome: efficacy of 3 dosing strategiesJ Clin Psychiatry6716241632PubMedCrossRefGoogle Scholar
  5. Landen, M, Nissbrandt, H, Allgulander, C, Sorvik, K, Ysander, C, Eriksson, E 2007Placebo-controlled trial comparing intermittent and continuous paroxetine in premenstrual dysphoric disorderNeuropsychopharmacology32153161PubMedCrossRefGoogle Scholar
  6. Montgomery, SA, Asberg, M 1979A new depression scale designed to be sensitive to changeBr J Psychiatry134382389PubMedCrossRefGoogle Scholar
  7. Pearlstein, TB, Halbreich, U, Batzar, ED, Brown, CS, Endicott, J, Frank, E, Freeman, EW, Harrison, WM, Haskett, RF, Stout, AL, Yonkers, KA 2000Psychosocial functioning in women with premenstrual dysphoric disorder before and after treatment with sertraline or placeboJ Clin Psychiatry61101109PubMedCrossRefGoogle Scholar
  8. Pearlstein, T, Yonkers, KA, Fayyad, R, Gillespie, JA 2005Pretreatment pattern of symptom expression in premenstrual dysphoric disorderJ Affect Disord85275282PubMedCrossRefGoogle Scholar
  9. Rapkin, A 2003A review of treatment of premenstrual syndrome and premenstrual dysphoric disorderPsychoneuroendocrinology283953PubMedCrossRefGoogle Scholar
  10. Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R, Dunbar, GC 1998The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10J Clin Psychiatry592233PubMedGoogle Scholar
  11. Steiner, M, Pearlstein, T 2000Premenstrual dysphoria and the serotonin system: pathophysiology and treatmentJ Clin Psychiatry611721PubMedGoogle Scholar
  12. Steiner, M, Haskett, RF, Carroll, BJ 1980Premenstrual tension syndrome: The development of research diagnostic criteria and new rating scalesActa Psychiatr Scand62177190PubMedGoogle Scholar
  13. Steiner, M, Brown, E, Trzepacz, P, Dillon, J, Berger, C, Carter, D, Reid, R, Stewart, D 2003Fluoxetine improves functional work capacity in women with premenstrual dysphoric disorderArch Womens Ment Health67177PubMedCrossRefGoogle Scholar
  14. Steiner, M, Hirschberg, AL, Bergeron, R, Holland, F, Gee, MD, Van Erp, E 2005Luteal phase dosing with paroxetine controlled release (CR) in the treatment of premenstrual dysphoric disorderAm J Obstet Gynecol193352360PubMedCrossRefGoogle Scholar
  15. Wyatt KM, Dimmock PW, O’Brien PMS (2002) Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database of Systematic Reviews, Issue 3. Art. No.: CD001396. DOI:10.1002/14651858.CD001396.Google Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • L. N. Ravindran
    • 1
  • S.-A. Woods
    • 2
  • M. Steiner
    • 3
  • A. V. Ravindran
    • 1
  1. 1.Department of PsychiatryUniversity of TorontoTorontoCanada
  2. 2.Department of PsychiatryUniversity of OttawaOttawaCanada
  3. 3.Department of PsychiatryMcMaster UniversityHamiltonCanada

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