Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone
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One-pot tandem synthesis was for the first time applied to attach fluorophore to the amino acid side chain, yielding amino acid ready for peptide coupling at the N-terminus, and also upon activation at the C-terminus. Two new compounds differing only in fluorophore-linker length showed exceptional fluorimetric and CD recognition between DS-RNA and DS-DNA, thus being promising beacons for versatile peptide incorporation.
KeywordsFluorescent amino acid One-pot synthesis DNA/RNA recognition Fluorescence∙CD
This work has been supported by the Croatian Science Foundation project 1477. Special thanks go to Prof. Todor Deligeorgiev and Dr. Atanas Kurutos for fruitful discussions and advice.
Compliance with ethical standards
Conflict of interest
The authors declare that there are no conflicts of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
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