Efficient synthesis of both diastereomers of β,γ-diamino acids from phenylalanine and tryptophan
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We synthesized in a few steps both diastereomers of orthogonally protected β,γ-diamino acids starting from l-phenylalanine or l-tryptophan. These final compounds are interesting building blocks for peptide synthesis and foldamer chemistry. The key step is a Blaise reaction performed under ultrasound conditions.
KeywordsNon proteinogenic amino acid synthesis Blaise reaction Asymmetric synthesis β-amino acid γ-amino acid
This research was supported by the M.E.S.R. (Doctoral Grant to A.S.).
Compliance with ethical standards
This research does not involve any human or animal participant.
Conflict of interest
The authors declare that they have no conflict of interest.
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