β,γ-Diamino acid: an original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group
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Using a β,γ-diamino acid, several small hybrid α/γ peptides have been synthesized and their conformations investigated through extensive NMR studies and molecular dynamics. A tripeptide and a tetrapeptide have thus shown several hydrogen bonds in solution, including a 13-membered ring involving the β-nitrogen.
KeywordsPeptide γ-amino acid Foldamer NMR Molecular dynamics Structure
This research was supported by the M.E.S.R. (doctoral Grant to A.S.) and by ANR Grants (no ANR-08-JCJC0099 and ANR-12-JS08-0005-01).
Conflict of interest
The authors declare that they have no conflict of interest.