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Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

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Abstract

The twenty first century has witnessed several advances in synthetic chemistry, among them microreactors. It is expected that these devices will have a considerable impact on synthetic organic chemistry since they offer a wide range of applications in various fields. Perhaps the synthesis of peptides deserves mention in this regard as these molecules are emerging as therapeutics and offer several advantages over the so-called small molecules. This minireview does not aim to address microreactors in detail, but explains various peptide synthesis methods that involve microfluidic techniques, highlighting the need for further improvement and expansion of microdevices/microreactors.

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Authors declare that they have no conflict of interest.

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Correspondence to Fernando Albericio.

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Ramesh, S., Cherkupally, P., de la Torre, B.G. et al. Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!. Amino Acids 46, 2091–2104 (2014). https://doi.org/10.1007/s00726-014-1776-1

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Keywords

  • Microreactors
  • Continuous flow
  • Peptide synthesis
  • Applications
  • Amide formation