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Amino Acids

, Volume 46, Issue 5, pp 1147–1157 | Cite as

Effect of taurine and potential interactions with caffeine on cardiovascular function

  • Stephen W. SchafferEmail author
  • Kayoko Shimada
  • Chian Ju Jong
  • Takashi Ito
  • Junichi Azuma
  • Kyoko Takahashi
Review Article

Abstract

The major impetus behind the rise in energy drink popularity among adults is their ability to heighten mental alertness, improve physical performance and supply energy. However, accompanying the exponential growth in energy drink usage have been recent case reports and analyses from the National Poison Data System, raising questions regarding the safety of energy drinks. Most of the safety concerns have centered on the effect of energy drinks on cardiovascular and central nervous system function. Although the effects of caffeine excess have been widely studied, little information is available on potential interactions between the other active ingredients of energy drinks and caffeine. One of the active ingredients often mentioned as a candidate for interactions with caffeine is the beta-amino acid, taurine. Although taurine is considered a conditionally essential nutrient for humans and is thought to play a key role in several human diseases, clinical studies evaluating the effects of taurine are limited. However, based on this review regarding possible interactions between caffeine and taurine, we conclude that taurine should neutralize several untoward effects of caffeine excess. In agreement with this conclusion, the European Union’s Scientific Committee on Food published a report in March 2003 summarizing its investigation into potential interactions of the ingredients in energy drinks. At the cardiovascular level, they concluded that “if there are any interactions between caffeine and taurine, taurine might reduce the cardiovascular effects of caffeine.” Although these interactions remain to be further examined in humans, the physiological functions of taurine appear to be inconsistent with the adverse cardiovascular symptoms associated with excessive consumption of caffeine–taurine containing beverages.

Keywords

Caffeine–taurine interactions Energy drinks Physiological functions of taurine 

Notes

Conflict of interest

Dr. Stephen Schaffer serves as a consultant of Red Bull. All other authors declare that they have no conflict of interest with respect to this manuscript.

References

  1. Abebe W, Mozaffari MS (2000) Effect of chronic taurine treatment on reactivity of rat aorta. Amino Acids 19:615–623PubMedGoogle Scholar
  2. Abebe W, Mozaffari MS (2004) Effect of taurine deficiency on adenosine receptor-mediated relaxation of the rat aorta. Vasc Pharmacol 40:219–228Google Scholar
  3. Abebe W, Mozaffari MS (2011) Role of taurine in the vasculature: an overview of experimental and human studies. Am J Cardiovasc Dis 1:293–311PubMedCentralPubMedGoogle Scholar
  4. Aguilar F, Charrondiere UR, Dusemund B, Galtier P, Gilbert J, Gott DM, Grilli S, Guertler R, Kass GEN, Koenig J, Lambre C, Larsen JC, Leblanc JC, Mortensen A, Parent-Massin D, Pratt I, Rietjens IMCM, Stankovic I, Tobback P, Verguieva T, Woutersen RA (2009) The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks. EFSA J 935:1–31Google Scholar
  5. Alford C, Cox H, Wescott R (2001) The effects of red bull energy drink on human performance and mood. Amino Acids 21:139–150PubMedGoogle Scholar
  6. American Heart Association (2007) Energy drinks may pose risks for people with high blood pressure, heart disease. News release 11.06.07, Scientific Sessions, OrlandoGoogle Scholar
  7. Azuma J, Sawamura A, Awata N, Ohta H, Hamaguchi T, Harada H, Takihara K, Hasegawa H, Yamagami T, Ishiyama T et al (1985) Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial. Clin Cardiol 8:276–282PubMedGoogle Scholar
  8. Baum M, Weiss M (2001) The influence of a taurine containing drink on cardiac parameters before and after exercise measured by echocardiography. Amino Acids 20:75–82 Google Scholar
  9. Berger AJ, Alford K (2009) Cardiac arrest in a young man following excess consumption of caffeinated “energy drinks”. Med J Aust 190:41–43PubMedGoogle Scholar
  10. Bichler A, Swenson A, Harris MA (2006) A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 31:471–476PubMedGoogle Scholar
  11. Burg MB, Kwon ED, Kultz D (1997) Regulation of gene expression by hypertonicity. Annu Rev Physiol 59:437–455PubMedGoogle Scholar
  12. Cannon ME, Cooke CT, McCarthy JS (2001) Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. Med J Aust 174:520–521PubMedGoogle Scholar
  13. Chahine R, Feng J (1998) Protective effects of taurine against reperfusion-induced arrhythmias in isolated ischemic rat heart. Arzneimittelforschung 48:360–364PubMedGoogle Scholar
  14. Chen W, Matuda K, Nishimura N, Yokogoshi H (2004) The effect of taurine on cholesterol degradation in mice fed a high cholesterol diet. Life Sci 74:1889–1898PubMedGoogle Scholar
  15. Chovan JP, Kulakowski EC, Sheakowski S, Schaffer SW (1980) Calcium regulation by the low-affinity taurine binding sarcolemma. Mol Pharmacol 17:295–300PubMedGoogle Scholar
  16. Daly JW (1993) Mechanism of action of caffeine. In: Garattini S (ed) Caffeine, coffee and health. Raven Press, New York, pp 97–150Google Scholar
  17. DiRocco JR, During A, Morelli PJ, Heyden M, Biancaniello TA (2011) Atrial fibrillation in healthy adolescents after highly caffeinated beverage consumption: two case reports. J Med Case Rep 5:18Google Scholar
  18. Dobmeyer DJ, Stine RA, Leier CV, Greenberg R, Schaal SF (1983) The arrhythmogenic effects of caffeine in human beings. N Engl J Med 308:814–816PubMedGoogle Scholar
  19. Eby G, Halcomb WW (2006) Elimination of cardiac arrhythmias using oral taurine and l-arginine with case histories: hypothesis for nitric oxide stabilization of the sinus node. Med Hypotheses 67:1200–1204PubMedGoogle Scholar
  20. El Idrissi A, Messing J, Sclia J, Trenkner E (2003) Prevention of epileptic seizures by taurine. Adv Exp Med Biol 526:515–525PubMedGoogle Scholar
  21. El Idrissi A, Shen CH, L-Amoreaux WJ (2013) Neuroprotective role of taurine during aging. Amino Acids 45:735–750PubMedGoogle Scholar
  22. Franconi F, Martini F, Stendardi I, Matucci R, Lucilla Z, Giotti A (1982) Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips. Biochem Pharmacol 31:3181–3185PubMedGoogle Scholar
  23. Franks AM, Schmidt JM, McCain KR, Fraer M (2012) Comparison of the effects of energy drink versus caffeine supplementation on indices of 24-hour ambulatory blood pressure. Ann Pharmacother 46:192–199PubMedGoogle Scholar
  24. Fujita T, Katsuyuki A, Noda H, Yasushi I, Sato Y (1987) Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation 75:525–532PubMedGoogle Scholar
  25. Gaull GE (1986) Taurine as a conditionally essential nutrient in man. J Am Coll Nutr 5:121–125PubMedGoogle Scholar
  26. Geiss KR, Jester I, Falke W, Hamm M, Waag KL (1994) The effect of taurine-containing drink on performance in 10 endurance athletes. Amino Acids 7:45–56PubMedGoogle Scholar
  27. Gentile S, Bologna E, Terracina D, Angelico M (1994) Taurine-induced diuresis and natriuresis in cirrhotic patients with ascites. Life Sci 54:1585–1593PubMedGoogle Scholar
  28. Gunja N, Brown JA (2012) Energy drinks: health risks and toxicity. Med J Aust 196:46–49PubMedGoogle Scholar
  29. Hakim AA, Ross GW, Curb JD, Rodriguez BL, Burchfiel CM, Sharp DS, Yano K, Abbott RD (1998) Coffee consumption in hypertensive men in older middle-age and the risk of stroke: the Honolulu Heart Program. J Clin Epidemiol 51:487–494PubMedGoogle Scholar
  30. Hano T, Kasano M, Tomari H, Iwane N (2009) Taurine suppresses pressor response through the inhibition of sympathetic nerve activity and the improvement in baro-reflex sensitivity of spontaneously hypertensive rats. Adv Exp Med Biol 643:57–63PubMedGoogle Scholar
  31. Hayes KC, Carey RE (1975) Retinal degeneration associated with taurine deficiency in the cat. Science 188:949–951PubMedGoogle Scholar
  32. Hayes KC, Pronczuk A, Addesa AE, Stephan ZF (1989) Taurine modulates platelet aggregation in cats and humans. Am J Clin Nutr 49:1211–1216PubMedGoogle Scholar
  33. Higgins JP (2013) Endothelial function acutely worse after drinking energy beverage. Int J Cardiol 168:e47–e49PubMedGoogle Scholar
  34. Hoffmann EK, Lambert IH, Pedersen SF (2009) Physiology of cell volume regulation in vertebrates. Physiol Rev 89:193–277PubMedGoogle Scholar
  35. Holloway C, Kotsanas G, Wendt I (1999) Acute effects of taurine on intracellular calcium in normal and diabetic cardiac myocytes. Pflugers Arch 438:384–391PubMedGoogle Scholar
  36. Huang DY, Boini KM, Lang PA, Grahammer F, Duszenko M, Heller-Stilb B, Warskulat U, Haeussinger D, Lang F, Vallon V (2006) Impaired ability to increase water excretion in mice lacking the taurine transporter gene TAUT. Pflugers Arch 451:668–677PubMedGoogle Scholar
  37. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101–163PubMedGoogle Scholar
  38. Ijiri Y, Ikarugi H, Tamura Y, Ura M, Morishita M, Hamada A, Mori M, Mori H, Yamori Y, Ishii H, Yamamoto J (2013) Antithrombotic effect of taurine in healthy Japanese people may be related to an increased endogenous thrombolytic activity. Thromb Res 131:158–161PubMedGoogle Scholar
  39. Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, Schaffer SW, Fujio Y, Azuma J (2008) Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol 44:927–937PubMedGoogle Scholar
  40. James JE (2004) Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosom Med 66:63–71PubMedGoogle Scholar
  41. Jong CJ, Azuma J, Schaffer S (2012) Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 42:2223–2232PubMedGoogle Scholar
  42. Juliano LM, Griffiths RR (2004) A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology 176:1–29PubMedGoogle Scholar
  43. Kim C, Park E, Quinn MR, Schuller-Levis G (1996) The production of superoxide anion and nitric oxide by cultured murine leukocytes and the accumulation of TNF-alpha in the conditioned media is inhibited by taurine chloramines. Immunopharmacology 34:89–95PubMedGoogle Scholar
  44. Kirino Y, Goto Y, Campos Y, Arenas J, Suzuki T (2005) Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. Proc Natl Acad Sci 102:7127–7132PubMedCentralPubMedGoogle Scholar
  45. Knopf K, Sturman JA, Armstrong M, Hayes KC (1978) Taurine: an essential nutrient for the cat. J Nutr 108:773–778PubMedGoogle Scholar
  46. Kohashi N, Okabayashi Y, Hama J, Katori R (1983) Decreased urinary taurine in essential hypertension. Prog Clin Biol Res 125:73–87PubMedGoogle Scholar
  47. Kokubo Y, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S (2013) The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort. Stroke 44:1369–1374Google Scholar
  48. Kondo Y, Toda Y, Kitajima H, Oda H, Nagate T, Kameo K, Murakami S (2001) Taurine inhibits development of atherosclerotic lesions in apolipoprotein E-deficient mice. Clin Exp Pharmacol Physiol 28:809–815PubMedGoogle Scholar
  49. Kontny E, Rudnicka W, Kowalczewski J, Marcinkiewicz J, Maslinski W (2003) Selective inhibition of cyclooxygenase 2-generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramines. Arthritis Rheum 48:1551–1555PubMedGoogle Scholar
  50. Kumar R (2009) Role of naturally occurring osmolytes in protein folding and stability. Arch Biochem Biophys 491:1–6PubMedGoogle Scholar
  51. Lake N, de Roode M, Nattel S (1987) Effects of taurine depletion on rat cardiac electrophysiology: in vivo and in vitro studies. Life Sci 40:997–1005PubMedGoogle Scholar
  52. Lane JD, Williams R (1985) Caffeine affects cardiovascular responses to stress. Psychophysiology 22:648–655PubMedGoogle Scholar
  53. Lang F, Busch GL, Ritter M, Voelkl H, Waldegger S, Gulbins E, Haeussinger D (1998) Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:247–306PubMedGoogle Scholar
  54. Larsson S, Orsini N (2011) Coffee consumption and risk of stroke: a dose-response meta-analysis of prospective studies. Am J Epidemiol 174:993–1001PubMedGoogle Scholar
  55. Li N, Sawamura M, Nara Y, Ikeda K, Yamori Y (1996) Direct inhibitory effects of taurine on norepinephrine-induced contraction in mesenteric artery of stroke-prone spontaneously hypertensive rats. Adv Exp Med Biol 403:257–262PubMedGoogle Scholar
  56. Lovallo WR, Pincomb G, Sung BH, Passey RB, Sausen KP, Wilson MF (1989) Caffeine may potentiate adrenocortical stress response in hypertension-prone men. Hypertension 14:170–176PubMedGoogle Scholar
  57. Marcinkiewicz J, Grabowska A, Bereta J, Bryniarski K, Nowak B (1998) Taurine chloramines down-regulates the generation of murine neutrophil inflammatory mediators. Immunopharmacology 40:27–38PubMedGoogle Scholar
  58. Mesas AE, Leon-Munoz LM, Rodriguez-Artalejo F, Lopez-Garcia E (2011) The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review of meta-analysis. Am J Clin Nutr 94:1113–1126PubMedGoogle Scholar
  59. Mitchell DC, Knight CA, Hockenberry J, Teplansky R, Hartman TJ (2014) Beverage caffeine intakes in the US. Food Chem Toxicol 63C:136–142Google Scholar
  60. Mizushima S, Nara Y, Sawamura M, Yamori Y (1996) Effects of oral taurine supplementation on lipids and sympathetic nerve tone. Adv Exp Med Biol 403:615–622PubMedGoogle Scholar
  61. Mozaffari MS, Schaffer D (2001) Taurine modulates arginine vasopressin-mediated regulation of renal function. J Cardiovasc Pharmacol 37:742–750PubMedGoogle Scholar
  62. Mozaffari MS, Warren BK, Azuma J, Schaffer SW (1998) Renal excretory responses to taurine-depleted rats to hypotonic and hypertonic saline infusion. Amino Acids 15:109–116PubMedGoogle Scholar
  63. Mozaffari MS, Patel C, Abdelsayed R, Schaffer SW (2006) Accelerated NaCl-induced hypertension in taurine deficient rat: role of renal function. Kidney Int 70:329–337PubMedGoogle Scholar
  64. Murakami S, Kondo Y, Toda Y, Kitajima H, Kameo K, Sakono M, Fukuda N (2002) Effect of taurine on cholesterol metabolism in hamsters: upregulation of low density lipoprotein (LDL) receptor by taurine. Life Sci 70:2355–2366PubMedGoogle Scholar
  65. Namdar M, Koepfli P, Grathowohl R, Siegrist PT, Klainguti M, Schepis T, Delaloye R, Wyss CA, Fleischmann SP, Gaemperli O, Kaufmann PA (2006) Caffeine decreases exercise-induced myocardial flow reserve. J Am Coll Cardiol 47:405–410PubMedGoogle Scholar
  66. Namdar M, Schepis T, Koepfli P, Gaemperli O, Siegrist PT, Grathowohl R, Valenta I, Delaloye R, Klainguti M, Wyss CA, Luscher TF, Kaufmann PA (2009) Caffeine impairs myocardial blood flow response to physical exercise in patients with coronary artery disease as well as in age-matched controls. PLoS One 4:e5665PubMedCentralPubMedGoogle Scholar
  67. Nara Y, Yamori Y, Lovenberg W (1978) Effect of dietary taurine on blood pressure in spontaneously hypertensive rats. Biochem Pharmacol 27:2689–2692PubMedGoogle Scholar
  68. Nawrot P, Jordan S, Eastwood J, Rotsein J, Hugenholtz A, Feeley M (2003) Effects of caffeine on human health. Food Addit Contam 20:1–30PubMedGoogle Scholar
  69. Nishida S, Satoh H (2009) Vascular modulation of rat aorta by taurine. Adv Exp Med Biol 643:37–46PubMedGoogle Scholar
  70. Ohta H, Azuma J, Awata N, Hamaguchi T, Tanaka Y, Sawamura A, Kishimoto S, Sperelakis N (1988) Mechanism of the protective action of taurine against isoprenaline induced myocardial damage. Cardiovasc Res 22:407–413PubMedGoogle Scholar
  71. Palatini P, Ceolotto G, Ragazzo F, Dorigatti F, Saladini F, Papparella I, Mos L, Zanta G, Santonastaso M (2009) CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J Hypertens 27:1594–1601PubMedGoogle Scholar
  72. Park T, Oh J, Lee K (1999) Dietary taurine or glycine supplementation reduces plasma and liver cholesterol and triglyceride concentrations in rats fed a cholesterol-free diet. Nutr Res 19:1777–1789Google Scholar
  73. Park SH, Lee H, Park KK, Kim HW, Lee DH, Park T (2006) Taurine-induced changes in transcription profiling of metabolism-related genes in human hepatoma cells HepG2. Exp Med Biol 583:119–128Google Scholar
  74. Park IS, Kang YH, Kang JS (2007) Effects of taurine on plasma and liver lipids, erythrocyte ouabain sensitive Na efflux and platelet aggregation in Sprague Dawley rats. Nutr Res Pract 1:200–205PubMedCentralPubMedGoogle Scholar
  75. Pasantes-Morales H, Schousboe A (1997) Role of taurine in osmoregulation in brain cells: mechanisms and functional implications. Amino Acids 12:281–292Google Scholar
  76. Passmore A, Knodowe GB, Johnston GD (1987) Renal and cardiovascular effects of caffeine: a dose response study. Clin Sci 72:749–756PubMedGoogle Scholar
  77. Peake STC, Mehta PA, Dubrey SW (2007) Atrial fibrillation-related cardiomyopathy: a case report. J Med Case Rep 1:111PubMedCentralPubMedGoogle Scholar
  78. Pelchovitz DJ, Goldberger JJ (2011) Caffeine and cardiac arrhythmias: a review of the evidence. Am J Med 124:284–289PubMedGoogle Scholar
  79. Pendleton M, Brown S, Thomas C, Odle B (2012) Potential toxicity of caffeine when used as a dietary supplement for weight loss. J Diet Suppl 9:293–298PubMedGoogle Scholar
  80. Pion PD, Kittleson MD, Rogers QR, Morris JG (1987) Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science 237:764–768PubMedGoogle Scholar
  81. Ragsdale FR, Gronli TD, Batool N, Haight N, Mehaffrey A, McMahon EC, Nalli TW, Mannello CM, Sell CJ, McCann PJ, Kastello GM, Hooks T, Wilson T (2010) Effects of Red Bull energy drink on cardiovascular and renal function. Amino Acids 38:1193–1200PubMedGoogle Scholar
  82. Read WO, Welty JD (1963) Effect of taurine on epinephrine and digoxin induced irregularities of the dog heart. J Pharmacol Exp Ther 139:283–289PubMedGoogle Scholar
  83. Riesenhuber A, Boehm M, Posch M, Aufricht C (2006) Diuretic potential of energy drinks. Amino Acids 31:81–83PubMedGoogle Scholar
  84. Ristori MT, Verdetti J (1991) Effects of taurine on rat aorta in vitro. Fundam Clin Pharmacol 5:245–258PubMedGoogle Scholar
  85. Rogers PJ, Martin J, Smith C, Heatherley S, Smit H (2003) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology 152:167–173Google Scholar
  86. Sato Y, Ando K, Fujita T (1987) Role of sympathetic nervous system in hypotensive action of taurine in DOCA-salt rats. Hypertension 9:81–87PubMedGoogle Scholar
  87. Satoh H (1998) Inhibition of the fast Na+ current by taurine in guinea pig ventricular myocytes. Gen Pharmacol 31:155–157PubMedGoogle Scholar
  88. Satoh H, Sperelakis N (1998) Review of some actions of taurine on ion channels of cardiac muscle cells and others. Gen Pharmacol 30:451–463PubMedGoogle Scholar
  89. Savoca MR, Mackey ML, Evans CD, Wilson M, Ludwig DA, Harshfield GA (2005) Association of ambulatory blood pressure and dietary caffeine in adolescents. Am J Hypertens 18:116–120PubMedGoogle Scholar
  90. Sawamura A, Sada H, Azuma J, Kishimoto S, Sperelakis N (1990) Taurine modulates ion influx through cardiac Ca2+ channels. Cell Calcium 11:251–259PubMedGoogle Scholar
  91. Schaffer SW, Azuma J, Madura JD (1995) Mechanisms underlying taurine-mediated alterations in membrane function. Amino Acids 8:231–246PubMedGoogle Scholar
  92. Schaffer SW, Takahashi K, Azuma J (2000) Role of osmoregulation in the actions of taurine. Amino Acids 19:527–546PubMedGoogle Scholar
  93. Schaffer SW, Jong CJ, Ito T, Azuma J (2013) Role of taurine in the pathologies of MELAS and MERRF. Amino Acids 46:1414–1418Google Scholar
  94. Schmidt RM, McIntire LK, Caldwell JA, Hallman C (2008) Prevalence of energy-drink and supplement usage in a sample of air force personnel. Available at. www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA514723
  95. Schneider MB, Benjamin HJ (2011) Clinical report—sports drinks and energy drinks for children and adolescents: are they appropriate? Pediatrics 127:1182–1189Google Scholar
  96. Schuller-Levis GB, Park E (2003) Taurine: new implications for an old amino acid. FEMS Microbiol Lett 226:195–202PubMedGoogle Scholar
  97. Schuller-Levis GB, Park E (2004) Taurine and its chloramines: modulators of immunity. Neurochem Res 29:117–126PubMedGoogle Scholar
  98. Schuller-Levis G, Mehta PD, Rudelli R, Sturman J (1990) Immunologic consequences of taurine deficiency in cats. J Leukoc Biol 47:321–331PubMedGoogle Scholar
  99. Scientific Committee on Food (2003) Opinion of the Scientific Committee on Food on Additional information on “energy” drinks. Available online. http://europa.eu.int/comm/food/fs/sc/scf
  100. Scott MJ, El-Hassan M, Kahn AA (2011) Myocardial infarction in a young adult following the consumption of a caffeinated energy drink. BMJ Case Rep. doi: 10.1136/bcr.02.2011.3854
  101. Seifert SM, Schaechter JL, Hershorin ER, Lipshultz SE (2011) Health effects of energy drinks on children, adolescents and young adults. Pediatrics 127:511–528PubMedCentralPubMedGoogle Scholar
  102. Shirley DG, Walter SJ, Noormohamed FH (2002) Natriuretic effect of caffeine: assessment of segmental sodium reabsorption in humans. Clin Sci 103:461–466PubMedGoogle Scholar
  103. Singewald N, Kouvelas D, Chen F, Philippu A (1997) The release of inhibitory amino acids in the hypothalamus is tonically modified by impulses from aortic baroreceptors as a consequence of blood pressure fluctuations. Naunyn Schmiedebergs Arch Pharmacol 356:348–355PubMedGoogle Scholar
  104. Smith AP, Phillips W (1993) Effects of low doses of caffeine in coffee on human performance and mood. In: 15th International Scientific Colloquim on Coffee, vol 2. Association Scientifique Internationale de Café, Paris, pp 461–469Google Scholar
  105. Steele DS, Smith GL, Miller DJ (1990) The effects of taurine on Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ sensitivity of chemically skinned rat heart. J Physiol 422:499–511PubMedCentralPubMedGoogle Scholar
  106. Steinke L, Kalus JS, Dhanapal V, Lanfear DE, Berlie HD (2007) Energy drink consumption causes increases in blood pressure and heart rate. Circulation 116:II_831Google Scholar
  107. Steinke L, Lanfear DE, Dhanapal V, Kalus JS (2009) Effect of “energy drink” consumption on hemodynamic and electrocardiographic parameters in healthy young adults. Ann Pharmacother 43:596–602PubMedGoogle Scholar
  108. Sturman JA (1986) Nutritional taurine and central nervous system development. Ann NY Acad Sci 477:196–213PubMedGoogle Scholar
  109. Sung B, Lovallo W, Pincomb GA, Wilson MF (1990) Effects of caffeine on blood pressure response during exercise in normotensive healthy young men. Am J Cardiol 65:909–913PubMedGoogle Scholar
  110. Suzuki T, Suzuki T, Wada T, Saigo K, Watanabe K (2002) Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. EMBO J 21:6581–6589PubMedCentralPubMedGoogle Scholar
  111. Sved DW, Godsey JL, Ledyard SL, Mahoney AP, Stetson PL, Ho S, Myers NR, Resnis P, Renwick AG (2007) Absorption, tissue distribution, metabolism and elimination of taurine given orally to rats. Amino Acids 32:459–466PubMedGoogle Scholar
  112. Takihara K, Azuma J, Awata N, Ohta H, Hamaguchi T, Sawamura A, Tanaka Y, Kishimoto S, Sperelakis N (1986) Beneficial effect of taurine in rabbits with chronic congestive heart failure. Am Heart J 112:1278–1284PubMedGoogle Scholar
  113. Terlizzi R, Rocchi C, Serra M, Solieri L, Cortelli P (2008) Reversible postural tachycardia syndrome due to inadvertent overuse of Red Bull. Clin Auton Res 18:221–223PubMedGoogle Scholar
  114. Thomas EL, Grisham MB, Melton DF, Jefferson MM (1985) Evidence for a role of taurine in in vitro oxidative toxicity of neutrophils toward erythrocytes. J Biol Chem 260:3321–3329PubMedGoogle Scholar
  115. Trachtman H, Del Pizzo R, Rao P, Rujikarn N, Sturman JA (1989) Taurine lowers blood pressure in the spontaneously hypertensive rat by a catecholamine independent mechanism. Am J Hypertens 2:909–912PubMedGoogle Scholar
  116. Umemura T, Ueda K, Nishioka K, Hidaka T, Takemoto H, Nakamura S, Jitsuiki D, Soga J, Chayama K, Yoshizumi M, Higashi Y (2006) Effects of acute administration of caffeine on vascular function. Am J Cardiol 98:1538–1541Google Scholar
  117. United Nations Environment Program, Organization for Economic Cooperation and Development, Screening information dataset: Caffeine. Available at. http://www.chem.unep.ch/irptc/sids/OECDSIDS/Caffeine.pdf
  118. Vessey DA, Whitney J, Gollan JL (1983) The role of conjugation reactions in enhancing biliary secretion of bile acids. Biochem J 214:923–927PubMedCentralPubMedGoogle Scholar
  119. Walsh M, Marquardt K, Albertson T (2006) Adverse effects from ingestion of redline energy drinks. Clin Toxicol 44:642Google Scholar
  120. Watkins JB, Jarvenpaa A-L, Szczepanik-Van Leeuwen P, Klein PD, Rassin DK, Gaull G, Raiha NCR (1983) Feeding the low-birth weight infant: V. Effects of taurine, cholesterol, and human milk on bile acid kinetics. Gastroenterology 85:793–800PubMedGoogle Scholar
  121. Watson R, Woodman R, Lockette W (2010) Ephedra alkaloids inhibit platelet aggregation. Blood Coagul Fibrinolysis 21:266–271PubMedGoogle Scholar
  122. Wojcik OP, Koenig KL, Zeleniuch-Jacquotte A, Costa M, Chen Y (2009) The potential protective effects of taurine on coronary heart disease. Atherosclerosis 208:19–25PubMedCentralPubMedGoogle Scholar
  123. Worthley MI, Prabhu A, De Sciscio P, Schultz C, Sanders P, Willoughby SR (2010) Detrimental effects of energy drink consumption on platelet and endothelial function. Am J Med 123:184–187PubMedGoogle Scholar
  124. Wu JY, Wu H, Jin Y, Wei J, Sha D, Prentice H, Lee HH, Lin CH, Lee YH, Yang LL (2009) Mechanism of neuroprotective function of taurine. Adv Exp Med Biol 643:169–179PubMedGoogle Scholar
  125. Yamamoto J, Akabane S, Yoshimi H, Nakai M, Ikeda M (1985) Effects of taurine on stress-evoked hemodynamic and plasma catecholamine changes in spontaneously hypertensive rats. Hypertension 7:913–922PubMedGoogle Scholar
  126. Yamori Y, Liu L, Ikeda K, Miura A, Mizushima S, Miki T, Nara Y (2001) Distribution of twenty four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-CARDIAC Study. Hypertens Rev 24:453–457Google Scholar
  127. Yamori Y, Liu L, Mori M, Sagara M, Murakami S, Nara Y, Nizushima S (2009) Taurine as the nutritional factor for the longevity of the Japanese revealed by a world-wide epidemiological survey. Adv Exp Med Biol 643:13–25PubMedGoogle Scholar
  128. Yamori Y, Taguchi T, Hamada A, Kunimasa K, Mori H, Mori M (2010) Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci 17(Suppl 1):56Google Scholar
  129. Yin Y, Wen K, Wu Y, Kang Y, Lou J (2012) Inhibition of sodium current by taurine magnesium coordination compound prevents cesium chloride-induced arrhythmias. Biol Trace Elem Res 146:192–198PubMedGoogle Scholar
  130. Yokogoshi H, Mochizuki H, Nanami K, Hida Y, Miyachi F, Oda H (1999) Dietary enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet. J Nutr 129:1705–1712PubMedGoogle Scholar
  131. Zhang M, Bi L, Fang JH, Su XL, Da GL, Kuwamori T, Kagamimori S (2004) Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids 26:267–271PubMedGoogle Scholar
  132. Zucconi S, Volpato C, Adinolfi F, Gandini E, Gentile E, Loi A, Fioriti L (2013) Gathering consumption data on specific consumer groups of energy drinks. Supporting Publications 2013; EN-394. [190 pp]. Available online. www.efsa.europa.eu/publications

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© Springer-Verlag Wien 2014

Authors and Affiliations

  • Stephen W. Schaffer
    • 1
    Email author
  • Kayoko Shimada
    • 1
    • 3
  • Chian Ju Jong
    • 1
  • Takashi Ito
    • 2
  • Junichi Azuma
    • 2
  • Kyoko Takahashi
    • 3
  1. 1.Department of PharmacologyUniversity of South Alabama College of MedicineMobileUSA
  2. 2.School of PharmacyHyogo University of Health SciencesKobeJapan
  3. 3.Osaka University Graduate School of Pharmaceutical SciencesSuitaJapan

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