Amino Acids

, Volume 45, Issue 4, pp 811–819 | Cite as

Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells

  • Chien-Te Chou
  • Wen-Feng Lin
  • Zwe-Ling Kong
  • Shiow-Yi Chen
  • Deng-Fwu HwangEmail author
Original Article


The study investigated the effect of taurine on cell viability and neurotrophic gene expression in arsenite-treated human neuroblastoma SH-SY5Y cells. Arsenite-induced intracellular reactive oxygen species (ROS) and interrupted cell cycle in SH-SY5Y cells. In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells. In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.


Arsenite  Taurine  NDRG-4  BDNF  SIRT-1  Neurotrophic 



This study was supported by the National Science Council, Taiwan, and the Center of Excellence for Marine Bioenvironment and Biotechnology.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Chien-Te Chou
    • 1
  • Wen-Feng Lin
    • 1
  • Zwe-Ling Kong
    • 1
  • Shiow-Yi Chen
    • 2
  • Deng-Fwu Hwang
    • 1
    • 3
    • 4
    Email author
  1. 1.Department of Food ScienceNational Taiwan Ocean UniversityKeelung 202Taiwan, ROC
  2. 2.Institute of Bioscience and BiotechnologyNational Taiwan Ocean UniversityKeelungTaiwan, ROC
  3. 3.Department of Health and Nutrition BiotechnologyAsia UniversityTaichungTaiwan, ROC
  4. 4.Center of Excellence for Marine Bioenvironment and BiotechnologyNational Taiwan Ocean UniversityKeelungTaiwan, ROC

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