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Amino Acids

, Volume 43, Issue 2, pp 999–1004 | Cite as

The suppression of thymic stromal lymphopoietin expression by selenium

  • Phil-Dong Moon
  • Hyung-Min Kim
Short Communication

Abstract

Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis. Selenium (Se) has various effects such as antioxidant, antitumor, antiulcer, and anti-inflammatory effects. However, the effect of Se on the production of TSLP has not been clarified. Thus, we investigated how Se inhibits the production of TSLP in the human mast cell line, HMC-1 cells. Se suppressed the production and mRNA expression of TSLP in HMC-1 cells. The maximal inhibition rate of TSLP production by Se (10 μM) was 59.14 ± 1.10%. In addition, Se suppressed the nuclear factor-κB luciferase activity induced by phorbol myristate acetate plus A23187. In the activated HMC-1 cells, the activation of caspase-1 was increased; whereas the activation of caspase-1 was decreased by pretreatment with Se. These results suggest that Se can be used to treat inflammatory and atopic diseases through the suppression of TSLP.

Keywords

Thymic stromal lymphopoietin Selenium Nuclear factor-κB Caspase-1 

Abbreviations

AD

Atopic dermatitis

Se

Selenium

NF-κB

Nuclear factor-κB

PMA

Phorbol myristate acetate

TSLP

Thymic stromal lymphopoietin

Notes

Acknowledgments

This work was supported by a grant from the Kyung Hee University in 2011 (KHU-20110092).

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. Bhattacharya A, Turowski SG, San Martin ID, Rajput A, Rustum YM, Hoffman RM, Seshadri M (2011) Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer. Anticancer Res 31:387–393PubMedGoogle Scholar
  2. Bieber T (2010) Atopic dermatitis. Ann Dermatol 22:125–137PubMedCrossRefGoogle Scholar
  3. Blume-Peytavi U, Wahn U (2011) Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of methylprednisolone aceponate. J Eur Acad Dermatol Venereol 25:508–515PubMedCrossRefGoogle Scholar
  4. Boost KA, Hoegl S, Hofstetter C, Flondor M, Stegewerth K, Platacis I, Pfeilschifter J, Muhl H, Zwissler B (2007) Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Intensive Care Med 33:863–871PubMedCrossRefGoogle Scholar
  5. Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F (2010) Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One 5:e9258PubMedCrossRefGoogle Scholar
  6. Duntas LH (2009) Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res 41:443–447PubMedCrossRefGoogle Scholar
  7. Gordon JR, Burd PR, Galli SJ (1990) Mast cells as a source of multifunctional cytokines. Immunol Today 11:458–464PubMedCrossRefGoogle Scholar
  8. Gore F, Fawell J, Bartram J (2010) Too much or too little? A review of the conundrum of selenium. J Water Health 8:405–416PubMedCrossRefGoogle Scholar
  9. Hong SW, Kim MR, Lee EY, Kim JH, Kim YS, Jeon SG, Yang JM, Lee BJ, Pyun BY, Gho YS, Kim YK (2011) Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy 66:351–359PubMedCrossRefGoogle Scholar
  10. Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM (2000) ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 103:99–111PubMedCrossRefGoogle Scholar
  11. Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard WJ (2011) Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol 187:1207–1211PubMedCrossRefGoogle Scholar
  12. Kim SH, Johnson VJ, Shin TY, Sharma RP (2004) Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-kappaB signaling pathways. Exp Biol Med (Maywood) 229:203–213Google Scholar
  13. Kim JH, Kim BW, Kwon HJ, Nam SW (2011) Curative effect of selenium against indomethacin-induced gastric ulcers in rats. J Microbiol Biotechnol 21:400–404PubMedGoogle Scholar
  14. Lamkanfi M, Kalai M, Saelens X, Declercq W, Vandenabeele P (2004) Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity. J Biol Chem 279:24785–24793PubMedCrossRefGoogle Scholar
  15. Lamkanfi M, Kanneganti TD, Franchi L, Núñez G (2007) Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol 82:220–225PubMedCrossRefGoogle Scholar
  16. Lee HC, Ziegler SF (2007) Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc Natl Acad Sci USA 104:914–919PubMedCrossRefGoogle Scholar
  17. Lee HC, Headley MB, Iseki M, Ikuta K, Ziegler SF (2008) Cutting edge: inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor. J Immunol 181:5189–5193PubMedGoogle Scholar
  18. Liu YJ (2006) Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med 203:269–273PubMedCrossRefGoogle Scholar
  19. Mancini AJ, Kaulback K, Chamlin SL (2008) The socioeconomic impact of atopic dermatitis in the United States: a systematic review. Pediatr Dermatol 25:1–6PubMedCrossRefGoogle Scholar
  20. Moon PD, Kim HM (2011) Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells. Cytokine 54:239–243PubMedCrossRefGoogle Scholar
  21. Moon PD, Choi IH, Kim HM (2011) Epigallocatechin-3-O-gallate inhibits the production of thymic stromal lymphopoietin by the blockade of caspase-1/NF-κB pathway in mast cells. Amino Acids 2011. (Epub ahead of print)Google Scholar
  22. Oiwa M, Satoh T, Watanabe M, Niwa H, Hirai H, Nakamura M, Yokozeki H (2008) CRTH2-dependent, STAT6-independent induction of cedar pollen dermatitis. Clin Exp Allergy 38:1357–1366PubMedCrossRefGoogle Scholar
  23. Ozawa T, Koyama K, Ando T, Ohnuma Y, Hatsushika K, Ohba T, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A (2007) Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone. Mod Rheumatol 17:459–463PubMedCrossRefGoogle Scholar
  24. Rayman MP (2000) The importance of selenium to human health. Lancet 356:233–241PubMedCrossRefGoogle Scholar
  25. Reefer AJ, Hulse KE, Lannigan JA, Solga MD, Wright PW, Kelly LA, Patrie J, Chapman MD, Woodfolk JA (2010) Flow cytometry imaging identifies rare T(H)2 cells expressing thymic stromal lymphopoietin receptor in a “proallergic” milieu. J Allergy Clin Immunol 126:1049–1058, 1058 e1–e10Google Scholar
  26. Schneider C, Döcke WD, Zollner TM, Röse L (2009) Chronic mouse model of TMA-induced contact hypersensitivity. J Invest Dermatol 129:899–907PubMedCrossRefGoogle Scholar
  27. Schoonbroodt S, Legrand-Poels S, Best-Belpomme M, Piette J (1997) Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem J 321:777–785PubMedGoogle Scholar
  28. Yang J, Huang K, Qin S, Wu X, Zhao Z, Chen F (2009) Antibacterial action of selenium-enriched probiotics against pathogenic Escherichia coli. Dig Dis Sci 54:246–254PubMedCrossRefGoogle Scholar
  29. Youn HS, Lim HJ, Choi YJ, Lee JY, Lee MY, Ryu JH (2008) Selenium suppresses the activation of transcription factor NF-kappa B and IRF3 induced by TLR3 or TLR4 agonists. Int Immunopharmacol 8:495–501PubMedCrossRefGoogle Scholar
  30. Ziegler SF (2010) The role of thymic stromal lymphopoietin (TSLP) in allergic disorders. Curr Opin Immunol 22:795–799PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Pharmacology, College of Oriental Medicine, Institute of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea

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