Amino Acids

, Volume 43, Issue 2, pp 999–1004 | Cite as

The suppression of thymic stromal lymphopoietin expression by selenium

  • Phil-Dong Moon
  • Hyung-Min Kim
Short Communication


Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis. Selenium (Se) has various effects such as antioxidant, antitumor, antiulcer, and anti-inflammatory effects. However, the effect of Se on the production of TSLP has not been clarified. Thus, we investigated how Se inhibits the production of TSLP in the human mast cell line, HMC-1 cells. Se suppressed the production and mRNA expression of TSLP in HMC-1 cells. The maximal inhibition rate of TSLP production by Se (10 μM) was 59.14 ± 1.10%. In addition, Se suppressed the nuclear factor-κB luciferase activity induced by phorbol myristate acetate plus A23187. In the activated HMC-1 cells, the activation of caspase-1 was increased; whereas the activation of caspase-1 was decreased by pretreatment with Se. These results suggest that Se can be used to treat inflammatory and atopic diseases through the suppression of TSLP.


Thymic stromal lymphopoietin Selenium Nuclear factor-κB Caspase-1 



Atopic dermatitis




Nuclear factor-κB


Phorbol myristate acetate


Thymic stromal lymphopoietin



This work was supported by a grant from the Kyung Hee University in 2011 (KHU-20110092).

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of Pharmacology, College of Oriental Medicine, Institute of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea

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