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Amino Acids

, Volume 42, Issue 2–3, pp 597–610 | Cite as

A combined model of hepatic polyamine and sulfur amino acid metabolism to analyze S-adenosyl methionine availability

  • Armando Reyes-Palomares
  • Raúl Montañez
  • Francisca Sánchez-Jiménez
  • Miguel Ángel Medina
Original Article

Abstract

Many molecular details remain to be uncovered concerning the regulation of polyamine metabolism. A previous model of mammalian polyamine metabolism showed that S-adenosyl methionine availability could play a key role in polyamine homeostasis. To get a deeper insight in this prediction, we have built a combined model by integration of the previously published polyamine model and one-carbon and glutathione metabolism model, published by different research groups. The combined model is robust and it is able to achieve physiological steady-state values, as well as to reproduce the predictions of the individual models. Furthermore, a transition between two versions of our model with new regulatory factors added properly simulates the switch in methionine adenosyl transferase isozymes occurring when the liver enters in proliferative conditions. The combined model is useful to support the previous prediction on the role of S-adenosyl methionine availability in polyamine homeostasis. Furthermore, it could be easily adapted to get deeper insights on the connections of polyamines with energy metabolism.

Keywords

Metabolic modeling Systems biology Polyamines S-adenosyl methionine Methionine cycle Folate cycle 

Notes

Acknowledgments

Our experimental work is supported by grants PS09/02216, SAF2008-02522 and SAF2011-26518 (Spanish Ministry of Science and Innovation), and PIE P08-CTS-3759, CVI-6585 and funds from group BIO-267 (Andalusian Government). The “CIBER de Enfermedades Raras” is an initiative from the ISCIII (Spain). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ARP is the recipient of a FPU Fellowship (Spanish Ministry of Education).

Conflict of interest

The authors have declared no conflict of interest.

Supplementary material

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Supplementary material 1 (XML 328 kb)
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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Armando Reyes-Palomares
    • 1
    • 2
  • Raúl Montañez
    • 1
    • 3
  • Francisca Sánchez-Jiménez
    • 1
    • 2
  • Miguel Ángel Medina
    • 1
    • 2
  1. 1.Department of Molecular Biology and Biochemistry, Faculty of ScienceUniversity of MálagaMálagaSpain
  2. 2.Unit 741, CIBER de Enfermedades Raras (CIBERER), ISCIIIMálagaSpain
  3. 3.Institut de Biologia Evolutiva (CSIC-UPF)BarcelonaSpain

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