Amino Acids

, Volume 36, Issue 4, pp 685–691

A role for anti-transglutaminase 2 autoantibodies in the pathogenesis of coeliac disease?

Review Article

Abstract

Coeliac disease is an autoimmune-mediated disorder with both innate and adaptive immune components. The disease is triggered by dietary gluten, which provokes the development of a massive immune reaction leading to the destruction of the small-intestinal mucosal morphology and intestinal dysfunction. Besides the typical small-bowel symptoms extraintestinal manifestations may also arise in a subset of coeliac disease patients. In addition, gluten evokes the production of antibodies mainly targeting deamidated gluten peptides or transglutaminase 2. Although coeliac disease has traditionally been regarded as a T cell-mediated disorder, this review discusses the role of the gluten-induced disease-specific anti-transglutaminase 2-autoantibodies in the pathogenesis of the disease.

Keywords

Coeliac disease Transglutaminase 2 Autoantibodies Pathogenesis 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Paediatric Research CentreMedical School, University of Tampere and Tampere University HospitalTampereFinland
  2. 2.Medical School and Department of Gastroenterology and Alimentary Tract SurgeryUniversity of Tampere and Tampere University HospitalTampereFinland

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