Amino Acids

, Volume 35, Issue 2, pp 503–505

Micromolar concentration of kynurenic acid in rat small intestine

  • D. Kuc
  • W. Zgrajka
  • J. Parada-Turska
  • T. Urbanik-Sypniewska
  • W. A. Turski
Short Communication

Summary.

Kynurenic acid is an antagonist of glutamate and alpha-7 nicotinic acetylcholine receptors and an agonist of the g-protein-coupled receptor GPR35, which is predominantly expressed in immune and gastrointestinal tissues. In this study, we report that kynurenic acid is present in the lumen of rat small intestine in micromolar concentration sufficient to affect the GPR35 receptor. Moreover, we show that kynurenic acid can be produced by Escherichia coli. We suggest that kynurenic acid may modulate gastrointestinal function and integrity.

Keywords: Kynurenic acid – Small intestine – Rat 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • D. Kuc
    • 1
  • W. Zgrajka
    • 2
  • J. Parada-Turska
    • 3
  • T. Urbanik-Sypniewska
    • 4
  • W. A. Turski
    • 1
    • 2
  1. 1.Department of Experimental and Clinical PharmacologyMedical UniversityLublinPoland
  2. 2.Department of ToxicologyInstitute of Agricultural MedicineLublinPoland
  3. 3.Department of Rheumatology and Connective Tissue DiseasesMedical UniversityLublinPoland
  4. 4.Department of General MicrobiologyInstitute of Microbiology and Biotechnology, Maria Curie-Sklodowska UniversityLublinPoland

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