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Amino Acids

, Volume 34, Issue 2, pp 175–185 | Cite as

Structural properties of proteins specific to the myelin sheath

  • P. Kursula
Review Article

Summary.

The myelin sheath is an insulating membrane layer surrounding myelinated axons in vertebrates, which is formed when the plasma membrane of an oligodendrocyte or a Schwann cell wraps itself around the axon. A large fraction of the total protein in this membrane layer is comprised of only a small number of individual proteins, which have certain intriguing structural properties. The myelin proteins are implicated in a number of neurological diseases, including, for example, autoimmune diseases and peripheral neuropathies. In this review, the structural properties of a number of myelin-specific proteins are described.

Keywords: Myelin – Membrane protein – Unstructured protein – Posttranslational modification – Protein domain – Protein structure 

Abbreviations:

P0

myelin protein zero

MAG

myelin-associated glycoprotein

MOG

myelin/oligodendrocyte glycoprotein

MBP

myelin basic protein

MOBP

myelin/oligodendrocyte basic protein

CaM

calmodulin

P2

peripheral myelin protein 2

CNS

central nervous system

PNS

peripheral nervous system

OMgp

oligodendrocyte/myelin glycoprotein

CNPase

2′,3′-cyclic nucleotide 3′-phosphodiesterase

FABP

fatty acid binding protein

PnK

polynucleotide kinase

Ig

immunoglobulin

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References

  1. Afar, DE, Salzer, JL, Roder, J, Braun, PE, Bell, JC 1990Differential phosphorylation of myelin-associated glycoprotein isoforms in cell cultureJ Neurochem5514181426PubMedGoogle Scholar
  2. Ainger, K, Avossa, D, Diana, AS, Barry, C, Barbarese, E, Carson, JH 1997Transport and localization elements in myelin basic protein mRNAJ Cell Biol13810771087PubMedGoogle Scholar
  3. Attia, J, Hicks, L, Oikawa, K, Kay, CM, Dunn, RJ 1993Structural properties of the myelin-associated glycoprotein ectodomainJ Neurochem61718726PubMedCrossRefGoogle Scholar
  4. Beniac, DR, Luckevich, MD, Czarnota, GJ, Tompkins, TA, Ridsdale, RA, Ottensmeyer, FP, Moscarello, MA, Harauz, G 1997Three-dimensional structure of myelin basic protein. I. Reconstruction via angular reconstitution of randomly oriented single particlesJ Biol Chem27242614268PubMedGoogle Scholar
  5. Berlet, HH, Bischoff, H, Weinhardt, F 1994Divalent metals of myelin and their differential binding by myelin basic protein of bovine central nervous systemNeurosci Lett1797578PubMedGoogle Scholar
  6. Boccaccio, GL, Colman, DR 1995Myelin basic protein mRNA localization and polypeptide targetingJ Neurosci Res42277286PubMedGoogle Scholar
  7. Boerkoel, CF, Takashima, H, Stankiewicz, P, Garcia, CA, Leber, SM, Rhee-Morris, L, Lupski, JR 2001Periaxin mutations cause recessive Dejerine-Sottas neuropathyAm J Hum Genet68325333PubMedGoogle Scholar
  8. Boggs JM (2006) Myelin basic protein: a multifunctional protein. Cell Mol Life Sci (in press)Google Scholar
  9. Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U 2003Structural insights into the antigenicity of myelin oligodendrocyte glycoproteinProc Natl Acad Sci USA10094469451PubMedGoogle Scholar
  10. Carson, JH, Kwon, S, Barbarese, E 1998RNA trafficking in myelinating cellsCurr Opin Neurobiol8607612PubMedGoogle Scholar
  11. Carson, JH, Worboys, K, Ainger, K, Barbarese, E 1997Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubules and kinesinCell Motil Cytoskeleton38318328PubMedGoogle Scholar
  12. Chmurzynska, A 2006The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphismJ Appl Genet473948PubMedGoogle Scholar
  13. Clements, CS, Reid, HH, Beddoe, T, Tynan, FE, Perugini, MA, Johns, TG, Bernard, CC, Rossjohn, J 2003The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosisProc Natl Acad Sci USA1001105911064PubMedGoogle Scholar
  14. Combet, C, Blanchet, C, Geourjon, C, Deleage, G 2000NPS@: network protein sequence analysisTrends Biochem Sci25147150PubMedGoogle Scholar
  15. de Rosbo, NK, Kaye, JF, Eisenstein, M, Mendel, I, Hoeftberger, R, Lassmann, H, Milo, R, Ben-Nun, A 2004The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501J Immunol17314261435PubMedGoogle Scholar
  16. Drummond, GI, Iyer, NT, Keith, J 1962Hydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brainJ Biol Chem23735353539Google Scholar
  17. Dytrych, L, Sherman, DL, Gillespie, CS, Brophy, PJ 1998Two PDZ domain proteins encoded by the murine periaxin gene are the result of alternative intron retention and are differentially targeted in Schwann cellsJ Biol Chem27357945800PubMedGoogle Scholar
  18. Earl, C, Chantry, A, Mohammad, N, Glynn, P 1988Zinc ions stabilise the association of basic protein with brain myelin membranesJ Neurochem51718724PubMedGoogle Scholar
  19. Eichberg, J 2002Myelin P0: new knowledge and new rolesNeurochem Res2713311340PubMedGoogle Scholar
  20. El-Amraoui, A, Schonn, JS, Kussel-Andermann, P, Blanchard, S, Desnos, C, Henry, JP, Wolfrum, U, Darchen, F, Petit, C 2002MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomesEMBO Rep3463470PubMedGoogle Scholar
  21. Everly, JL, Brady, RO, Quarles, RH 1973Evidence that the major protein in rat sciatic nerve myelin is a glycoproteinJ Neurochem21329334PubMedGoogle Scholar
  22. Eylar, EH, Szymanska, I, Ishaque, A, Ramwani, J, Dubiski, S 1980Localization of the P2 protein in peripheral nerve myelinJ Immunol12410861092PubMedGoogle Scholar
  23. Fahrig, T, Probstmeier, R, Spiess, E, Meyer-Franke, A, Kirchhoff, F, Drescher, B, Schachner, M 1993Functional topography of the myelin-associated glycoprotein. I. Mapping of domains by electron microscopyEur J Neurosci511181126PubMedGoogle Scholar
  24. Figlewicz, DA, Quarles, RH, Johnson, D, Barbarash, GR, Sternberger, NH 1981Biochemical demonstration of the myelin-associated glycoprotein in the peripheral nervous systemJ Neurochem37749758PubMedGoogle Scholar
  25. Frail, DE, Braun, PE 1984Two developmentally regulated messenger RNAs differing in their coding region may exist for the myelin-associated glycoproteinJ Biol Chem2591485714862PubMedGoogle Scholar
  26. Gillespie, CS, Sherman, DL, Blair, GE, Brophy, PJ 1994Periaxin, a novel protein of myelinating Schwann cells with a possible role in axonal ensheathmentNeuron12497508PubMedGoogle Scholar
  27. Gong, H, Amemiya, T 2001Optic nerve changes in zinc-deficient ratsExp Eye Res72363369PubMedGoogle Scholar
  28. Gouet, P, Courcelle, E, Stuart, DI, Metoz, F 1999ESPript: analysis of multiple sequence alignments in PostScriptBioinformatics15305308PubMedGoogle Scholar
  29. Guilbot, A, Williams, A, Ravise, N, Verny, C, Brice, A, Sherman, DL, Brophy, PJ, LeGuern, E, Delague, V, Bareil, C, Megarbane, A, Claustres, M 2001A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth diseaseHum Mol Genet10415421PubMedGoogle Scholar
  30. Haas, H, Oliveira, CL, Torriani, IL, Polverini, E, Fasano, A, Carlone, G, Cavatorta, P, Riccio, P 2004Small angle X-ray scattering from lipid-bound myelin basic protein in solutionBiophys J86455460PubMedGoogle Scholar
  31. Harauz, G, Ishiyama, N, Hill, CM, Bates, IR, Libich, DS, Fares, C 2004Myelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosisMicron35503542PubMedGoogle Scholar
  32. Harauz G, Musse AA (2006) A tale of two citrullines – structural and functional aspects of myelin basic protein deimination in health and disease. Neurochem Res (in press)Google Scholar
  33. Holz, A, Bielekova, B, Martin, R, Oldstone, MB 2000Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosisJ Immunol16411031109PubMedGoogle Scholar
  34. Holz, A, Schaeren-Wiemers, N, Schaefer, C, Pott, U, Colello, RJ, Schwab, ME 1996Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic proteinJ Neurosci16467477PubMedGoogle Scholar
  35. Hughes, RA, Cornblath, DR 2005Guillain-Barre syndromeLancet36616531666PubMedGoogle Scholar
  36. Hughes, RA, Hadden, RD, Gregson, NA, Smith, KJ 1999Pathogenesis of Guillain-Barre syndromeJ Neuroimmunol1007497PubMedGoogle Scholar
  37. Hunter, DJ, Macmaster, R, Roszak, AW, Riboldi-Tunnicliffe, A, Griffiths, IR, Freer, AA 2005Structure of myelin P2 protein from equine spinal cordActa Crystallogr D Biol Crystallogr6110671071PubMedGoogle Scholar
  38. Iglesias, A, Bauer, J, Litzenburger, T, Schubart, A, Linington, C 2001T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosisGlia36220234PubMedGoogle Scholar
  39. Inouye, H, Kirschner, DA 1984Effects of ZnCl2 on membrane interactions in myelin of normal and shiverer miceBiochim Biophys Acta776197208PubMedGoogle Scholar
  40. Inouye, H, Tsuruta, H, Sedzik, J, Uyemura, K, Kirschner, DA 1999Tetrameric assembly of full-sequence protein zero myelin glycoprotein by synchrotron X-ray scatteringBiophys J76423437PubMedGoogle Scholar
  41. Jaramillo, ML, Afar, DE, Almazan, G, Bell, JC 1994Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling moleculesJ Biol Chem2692724027245PubMedGoogle Scholar
  42. Jones, TA, Bergfors, T, Sedzik, J, Unge, T 1988The three-dimensional structure of P2 myelin proteinEMBO J715971604PubMedGoogle Scholar
  43. Kaye, JF, Kerlero de Rosbo, N, Mendel, I, Flechter, S, Hoffman, M, Yust, I, Ben-Nun, A 2000The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS)J Neuroimmunol102189198PubMedGoogle Scholar
  44. Kelley, LA, MacCallum, RM, Sternberg, MJ 2000Enhanced genome annotation using structural profiles in the program 3D-PSSMJ Mol Biol299499520PubMedGoogle Scholar
  45. Kijima, K, Numakura, C, Shirahata, E, Sawaishi, Y, Shimohata, M, Igarashi, S, Tanaka, T, Hayasaka, K 2004Periaxin mutation causes early-onset but slow-progressive Charcot-Marie-Tooth diseaseJ Hum Genet49376379PubMedGoogle Scholar
  46. Kirchhoff, F, Hofer, HW, Schachner, M 1993Myelin-associated glycoprotein is phosphorylated by protein kinase CJ Neurosci Res36368381PubMedGoogle Scholar
  47. Kozlov, G, Lee, J, Elias, D, Gravel, M, Gutierrez, P, Ekiel, I, Braun, PE, Gehring, K 2003Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamilyJ Biol Chem2784602146028PubMedGoogle Scholar
  48. Kraulis, P 1991MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresJ Appl Cryst24946950Google Scholar
  49. Kursula, P 2000Cytoplasmic domains of the myelin-associated glycoprotein. Acta Univ Oul, D594Oulu University PressOulu, FinlandGoogle Scholar
  50. Kursula, P 2001The current status of structural studies on proteins of the myelin sheath (Review)Int J Mol Med8475479PubMedGoogle Scholar
  51. Kursula, P 2003Insights into the structure and function of the myelin-associated glycoproteinRec Res Dev Neurochem66580Google Scholar
  52. Kursula, P, Lehto, VP, Heape, AM 2000S100beta inhibits the phosphorylation of the L-MAG cytoplasmic domain by PKABrain Res Mol Brain Res76407410PubMedGoogle Scholar
  53. Kursula, P, Lehto, VP, Heape, AM 2001The small myelin-associated glycoprotein binds to tubulin and microtubulesBrain Res Mol Brain Res872230PubMedGoogle Scholar
  54. Kursula, P, Merilainen, G, Lehto, VP, Heape, AM 1999aThe small myelin-associated glycoprotein is a zinc-binding proteinJ Neurochem7321102118Google Scholar
  55. Kursula, P, Tikkanen, G, Lehto, VP, Nishikimi, M, Heape, AM 1999bCalcium-dependent interaction between the large myelin-associated glycoprotein and S100betaJ Neurochem7317241732Google Scholar
  56. Lai, C, Watson, JB, Bloom, FE, Sutcliffe, JG, Milner, RJ 1987Neural protein 1B236/myelin-associated glycoprotein (MAG) defines a subgroup of the immunoglobulin superfamilyImmunol Rev100129151PubMedGoogle Scholar
  57. Libich, DS, Hill, CM, Haines, JD, Harauz, G 2003Myelin basic protein has multiple calmodulin-binding sitesBiochem Biophys Res Commun308313319PubMedGoogle Scholar
  58. Maatta, JA, Kaldman, MS, Sakoda, S, Salmi, AA, Hinkkanen, AE 1998Encephalitogenicity of myelin-associated oligodendrocytic basic protein and 2′,3′-cyclic nucleotide 3′-phosphodiesterase for BALB/c and SJL miceImmunology95383388PubMedGoogle Scholar
  59. Martini, R, Schachner, M 1986Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerveJ Cell Biol10324392448PubMedGoogle Scholar
  60. Mata, M, Fink, DJ 1988Calmodulin distribution in peripheral nerve: an EM immunocytochemical studyBrain Res475297304PubMedGoogle Scholar
  61. May, AP, Robinson, RC, Vinson, M, Crocker, PR, Jones, EY 1998Crystal structure of the N-terminal domain of sialoadhesin in complex with 3′ sialyllactose at 1.85 Å resolutionMol Cell1719728PubMedGoogle Scholar
  62. Mazumder, R, Iyer, LM, Vasudevan, S, Aravind, L 2002Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamilyNucleic Acids Res3052295243PubMedGoogle Scholar
  63. McCallion, AS, Stewart, GJ, Montague, P, Griffiths, IR, Davies, RW 1999Splicing pattern, transcript start distribution, and DNA sequence of the mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic proteinMol Cell Neurosci13229236PubMedGoogle Scholar
  64. Muller, HW 1982Dissociation of CNPase dimer into catalytically active monomers by 1,4-dithiothreitol and urea. Protein-promoted reassemblyFEBS Lett1447780PubMedGoogle Scholar
  65. Muller, HW, Clapshaw, PA, Seifert, W 1981Two molecular forms of the isolated brain enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesteraseFEBS Lett1313740PubMedGoogle Scholar
  66. Niemann, A, Berger, P, Suter, U 2006Pathomechanisms of mutant proteins in Charcot-Marie-Tooth diseaseNeuromol Med8217242Google Scholar
  67. Ostermeier, C, Brunger, AT 1999Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3ACell96363374PubMedGoogle Scholar
  68. Pedraza, L, Owens, GC, Green, LA, Salzer, JL 1990The myelin-associated glycoproteins: membrane disposition, evidence of a novel disulfide linkage between immunoglobulin-like domains, and posttranslational palmitylationJ Cell Biol11126512661PubMedGoogle Scholar
  69. Polverini, E, Boggs, JM, Bates, IR, Harauz, G, Cavatorta, P 2004Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targetsJ Struct Biol148353369PubMedGoogle Scholar
  70. Quarles, RH, Everly, JL, Brady, RO 1973Myelin-associated glycoprotein: a developmental changeBrain Res58506509PubMedGoogle Scholar
  71. Riccio, P, Giovannelli, S, Bobba, A, Romito, E, Fasano, A, Bleve-Zacheo, T, Favilla, R, Quagliariello, E, Cavatorta, P 1995Specificity of zinc binding to myelin basic proteinNeurochem Res2011071113PubMedGoogle Scholar
  72. Ridsdale, RA, Beniac, DR, Tompkins, TA, Moscarello, MA, Harauz, G 1997Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosisJ Biol Chem27242694275PubMedGoogle Scholar
  73. Rostami, AM 1997P2-reactive T cells in inflammatory demyelination of the peripheral nerveJ Infect Dis176S160S163PubMedGoogle Scholar
  74. Sakamoto, Y, Kitamura, K, Yoshimura, K, Nishijima, T, Uyemura, K 1987Complete amino acid sequence of PO protein in bovine peripheral nerve myelinJ Biol Chem26242084214PubMedGoogle Scholar
  75. Sakamoto, Y, Tanaka, N, Ichimiya, T, Kurihara, T, Nakamura, KT 2005Crystal structure of the catalytic fragment of human brain 2′,3′-cyclic-nucleotide 3′-phosphodiesteraseJ Mol Biol346789800PubMedGoogle Scholar
  76. Sedzik, J, Carlone, G, Fasano, A, Liuzzi, GM, Riccio, P 2003Crystals of P2 myelin protein in lipid-bound formJ Struct Biol142292300PubMedGoogle Scholar
  77. Sedzik, J, Kirschner, DA 1992Is myelin basic protein crystallizable?Neurochem Res17157166PubMedGoogle Scholar
  78. Shapiro, L, Doyle, JP, Hensley, P, Colman, DR, Hendrickson, WA 1996Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelinNeuron17435449PubMedGoogle Scholar
  79. Shy, ME 2004Charcot-Marie-Tooth disease: an updateCurr Opin Neurol17579585PubMedGoogle Scholar
  80. Shy, ME, Gabel, CA, Vietorisz, EC, Latov, N 1986Characterization of oligosaccharides that bind to human anti-MAG antibodies and to the mouse monoclonal antibody HNK-1J Neuroimmunol12291298PubMedGoogle Scholar
  81. Shy, ME, Jani, A, Krajewski, K, Grandis, M, Lewis, RA, Li, J, Shy, RR, Balsamo, J, Lilien, J, Garbern, JY, Kamholz, J 2004Phenotypic clustering in MPZ mutationsBrain127371384PubMedGoogle Scholar
  82. Sospedra, M, Martin, R 2005Immunology of multiple sclerosisAnnu Rev Immunol23683747PubMedGoogle Scholar
  83. Stenmark, H, Aasland, R, Toh, BH, D’Arrigo, A 1996Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE fingerJ Biol Chem2712404824054PubMedGoogle Scholar
  84. Sternberger, NH, Quarles, RH, Itoyama, Y, Webster, HD 1979Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing ratProc Natl Acad Sci USA7615101514PubMedGoogle Scholar
  85. Tang, S, Shen, YJ, DeBellard, ME, Mukhopadhyay, G, Salzer, JL, Crocker, PR, Filbin, MT 1997Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition siteJ Cell Biol13813551366PubMedGoogle Scholar
  86. Thompson, AJ, Cronin, MS, Kirschner, DA 2002Myelin protein zero exists as dimers and tetramers in native membranes of Xenopus laevis peripheral nerveJ Neurosci Res67766771PubMedGoogle Scholar
  87. Trapp, BD, Andrews, SB, Wong, A, O’Connell, M, Griffin, JW 1989Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibresJ Neurocytol184760PubMedGoogle Scholar
  88. Trapp, BD, Dubois-Dalcq, M, Quarles, RH 1984Ultrastructural localization of P2 protein in actively myelinating rat Schwann cellsJ Neurochem43944948PubMedGoogle Scholar
  89. Trapp, BD, Quarles, RH 1982Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelinJ Cell Biol92877882PubMedGoogle Scholar
  90. Tsang, D, Tsang, YS, Ho, WK, Wong, RN 1997Myelin basic protein is a zinc-binding protein in brain: possible role in myelin compactionNeurochem Res22811819PubMedGoogle Scholar
  91. Tzakos, AG, Kursula, P, Troganis, A, Theodorou, V, Tselios, T, Svarnas, C, Matsoukas, J, Apostolopoulos, V, Gerothanassis, IP 2005Structure and function of the myelin proteins: current status and perspectives in relation to multiple sclerosisCurr Med Chem1215691587PubMedGoogle Scholar
  92. Uyemura, K, Yoshimura, K, Suzuki, M, Kitamura, K 1984Lipid binding activities of the P2 protein in peripheral nerve myelinNeurochem Res915091514PubMedGoogle Scholar
  93. Varughese, KI, Ruggeri, ZM, Celikel, R 2004Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domainActa Crystallogr D Biol Crystallogr60405411PubMedGoogle Scholar
  94. Voshol, H, van Zuylen, CW, Orberger, G, Vliegenthart, JF, Schachner, M 1996Structure of the HNK-1 carbohydrate epitope on bovine peripheral myelin glycoprotein P0J Biol Chem2712295722960PubMedGoogle Scholar
  95. Vourc’h, P, Andres, C 2004Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and functionBrain Res Brain Res Rev45115124PubMedGoogle Scholar
  96. Vourc’h, P, Dessay, S, Mbarek, O, Marouillat Vedrine, S, Muh, JP, Andres, C 2003aThe oligodendrocyte-myelin glycoprotein gene is highly expressed during the late stages of myelination in the rat central nervous systemBrain Res Dev Brain Res144159168Google Scholar
  97. Vourc’h, P, Moreau, T, Arbion, F, Marouillat-Vedrine, S, Muh, JP, Andres, C 2003bOligodendrocyte myelin glycoprotein growth inhibition function requires its conserved leucine-rich repeat domain, not its glycosylphosphatidyl-inositol anchorJ Neurochem85889897CrossRefGoogle Scholar
  98. Wang, LK, Lima, CD, Shuman, S 2002Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzymeEMBO J2138733880PubMedGoogle Scholar
  99. Watanabe, N, Wachi, S, Fujita, T 2003Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombinationJ Biol Chem2782610226110PubMedGoogle Scholar
  100. Yamamoto, Y, Mizuno, R, Nishimura, T, Ogawa, Y, Yoshikawa, H, Fujimura, H, Adachi, E, Kishimoto, T, Yanagihara, T, Sakoda, S 1994Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelinJ Biol Chem2693172531730PubMedGoogle Scholar
  101. Yamamoto, Y, Yoshikawa, H, Nagano, S, Kondoh, G, Sadahiro, S, Gotow, T, Yanagihara, T, Sakoda, S 1999Myelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelinEur J Neurosci11847855PubMedGoogle Scholar
  102. Yoshikawa, H 2001Myelin-associated oligodendrocytic basic protein modulates the arrangement of radial growth of the axon and the radial component of myelinMed Electron Microsc34160164PubMedGoogle Scholar
  103. Zarrinpar, A, Bhattacharyya, RP, Lim, WA 2003The structure and function of proline recognition domainsSci STKE2003RE8PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • P. Kursula
    • 1
  1. 1.Department of BiochemistryUniversity of OuluOuluFinland

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