Amino Acids

, Volume 30, Issue 3, pp 279–289 | Cite as

The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis

  • R. C. Harris
  • M. J. Tallon
  • M. Dunnett
  • L. Boobis
  • J. Coakley
  • H. J. Kim
  • J. L. Fallowfield
  • C. A. Hill
  • C. Sale
  • J. A. Wise
Article

Summary.

β-Alanine in blood-plasma when administered as A) histidine dipeptides (equivalent to 40 mg · kg−1 bwt of β-alanine) in chicken broth, or B) 10, C) 20 and D) 40 mg · kg−1 bwt β-alanine (CarnoSyn™, NAI, USA), peaked at 428 ± SE 66, 47 ± 13, 374 ± 68 and 833 ± 43 µM. Concentrations regained baseline at 2 h. Carnosine was not detected in plasma with A) although traces of this and anserine were found in urine. Loss of β-alanine in urine with B) to D) was <5%. Plasma taurine was increased by β-alanine ingestion but this did not result in any increased loss via urine. Pharmacodynamics were further investigated with 3 × B) per day given for 15 d. Dietary supplementation with I) 3.2 and II) 6.4 g · d−1 β-alanine (as multiple doses of 400 or 800 mg) or III) L-carnosine (isomolar to II) for 4 w resulted in significant increases in muscle carnosine estimated at 42.1, 64.2 and 65.8%.

Keywords: Carnosine – β-Alanine – Muscle – Buffering – Intracellular pH 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • R. C. Harris
    • 1
  • M. J. Tallon
    • 1
  • M. Dunnett
    • 1
  • L. Boobis
    • 2
  • J. Coakley
    • 3
  • H. J. Kim
    • 4
  • J. L. Fallowfield
    • 1
  • C. A. Hill
    • 1
  • C. Sale
    • 1
  • J. A. Wise
    • 5
  1. 1.School of Sports, Exercise and Health Sciences, University College ChichesterChichesterU.K.
  2. 2.Sunderland Royal HospitalSunderlandU.K.
  3. 3.Intensive Care UnitHomerton HospitalLondonU.K.
  4. 4.Human Exercise Physiology, Korea National Sport UniversitySeoulKorea
  5. 5.Natural Alternatives InternationalSan MarcosU.S.A.

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