Amino Acids

, Volume 23, Issue 1, pp 153–159

Modulation of glutamate receptors: Strategies for the development of novel antidepressants

  • P. Skolnick

DOI: 10.1007/s00726-001-0121-7

Cite this article as:
Skolnick, P. Amino Acids (2002) 23: 153. doi:10.1007/s00726-001-0121-7


 On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the principal limitations (i.e., delayed onset and low efficacy) that appear to be inherent to these conventional agents. In this brief overview, I summarize two glutamate-based approaches to develop novel antidepressants. These distinct and (on a cellular level) seemingly diametric strategies may converge on intracellular pathways that are also impacted upon by chronic treatment with biogenic amine based agents.

Keywords: NMDA antagonists Depression Behavioral despair AMPA AMPA receptor potentiators 

Copyright information

© Springer-Verlag Wien 2002

Authors and Affiliations

  • P. Skolnick
    • 1
  1. 1.DOV Pharmaceutical, Inc. Hackensack, New Jersey, U.S.A.US

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