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EPR and Mössbauer Characteristics of Aqueous Solutions of 57Fe-Dinitrosyl Iron Complexes with Glutathione and Hydroxyl Ligands

  • Valery E. Prusakov
  • Yury V. Maksimov
  • Dosymzhan Sh. Burbaev
  • Vladimir A. Serezhenkov
  • Rostislav R. Borodulin
  • Nikolay A. Tkachev
  • Vasak D. Mikoyan
  • Anatoly F. VaninEmail author
Original Paper
  • 22 Downloads

Abstract

Our electron paramagnetic resonance (EPR) studies have demonstrated that at 293 K and 77 K, the spin–lattice relaxation time, T1, of paramagnetic mononuclear dinitrosyl iron complexes (M-DNICs) with glutathione and hydroxyl ligands containing isotopes 57Fe and 56Fe notably exceeds the halflife of the Mössbauer transition, i.e., the lifetime of the 57Fe nucleus in the first excited state (10−7 s). The Mössbauer spectra of M-DNIC with hydroxyl ligands, binuclear DNIC with glutathione (B-DNIC) and sodium dithionite-treated solution of B-DNIC with glutathione did not display the presence of the magnetic hyperfine structure (MHFS) characteristic of M-DNIC with glutathione. The Mössbauer spectra of all these DNICs were characterized by quadrupole splitting. The results of a comprehensive comparative analysis of MHFS of M-DNIC with glutathione and that in DMF reduced sodium nitroprusside suggest that M-DNIC with glutathione have a low-spin (S = ½) d7 electronic configuration with the predominant localization of the unpaired electron on the d z 2 orbital of iron. This conclusion is fully consistent with the results of our previous studies of M-DNIC using the EPR method.

Notes

Acknowledgements

This work has been carried out in the framework of the State Programs of the Russian Federal Agency for Scientific Organizations (0082-2014-0001, No. AAAA-A17-117040610310-6 and 0082-2014-0008, No. AAAA-A17-117040310008-5). This work was also supported into framework of the state task for ICP RAS 0082-2014-0008, No AAAA-A17-117040310008-5. The study was sponsored by Russian academic excellence project “5-100” and supported by the Russian Foundation for Basic Research (Grant No. 18-04-00059a).

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Valery E. Prusakov
    • 1
  • Yury V. Maksimov
    • 1
  • Dosymzhan Sh. Burbaev
    • 1
  • Vladimir A. Serezhenkov
    • 1
  • Rostislav R. Borodulin
    • 1
  • Nikolay A. Tkachev
    • 1
  • Vasak D. Mikoyan
    • 1
  • Anatoly F. Vanin
    • 1
    • 2
    Email author
  1. 1.N. N. Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscowRussia
  2. 2.Institute for Regenerative MedicineI. M. Sechenov First Moscow State Medical UniversityMoscowRussia

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