Optimizing T1rho and T2 Values for Intervertebral Discs Obtained from the Combined T1rho and T2 Sequence

  • Rui Imamura
  • Hiroyuki TakashimaEmail author
  • Mitsuhiro Nakanishi
  • Yoshihiro Akatsuka
  • Hiroshi Nagahama
  • Tomoyuki Okuaki
  • Masami Yoneyama
  • Masamitsu Hatakenaka
Original Paper


To investigate the effect of the number of spin-lock (SL) and T2 preparation pulse using T1rho and T2 values obtained from the combined T1rho and T2 sequence. We included 30 patients who underwent magnetic resonance imaging of the lumbar spine because of low back pain and leg numbness, tingling, and pain. We used 3D turbo-field echo and the adiabatic pulse as SL pulse for T1rho mapping and the block pulse as T2 preparation pulse for T2 mapping of the combined T1rho and T2 sequence. The preparation time of T1rho and T2 was set at 0, 20, 40, 60, and 80 ms. We defined the T1rho and T2 values calculated from all SL and T2 preparation pulses as Dfull and decreased several number of SL and T2 preparation pulses from Dfull as other groups (D1, D2, and D3). We used the Bland–Altman analyses to estimate the systematic and proportional bias between Dfull and other groups. The 95% CI of the mean difference included zero in all groups. Therefore, systematic bias was not detected. The regression coefficients with D3 of the T1rho and T2 value were − 0.34 and − 0.23, respectively (p < 0.01). We detected the proportional bias in the T1rho and T2 values in only D3 (0 and 80 ms). An investigation of the T1rho and T2 values of IVDs using the combined T1rho and T2 sequence suggested that the accuracy of these values decreased with suitably adjusted three preparation pulses, facilitating the assessment of both T1rho and T2 values at approximately 10 min.



Our study was supported by a research sequence from Philips. T. O. and M.Y. of co-author are employee of Philips Japan. This work was supported by research grant of the Japan Society of Radiological Technology Hokkaido branch. We thank the staff of MR examination room for their help regarding the MR imaging.


  1. 1.
    C.H. Chen, K.Y. Hsu, W.J. Chen, C.H. Shih, J. Trauma 58, 1189–1193 (2005)CrossRefGoogle Scholar
  2. 2.
    W.H. Kirkaldy-Willis, H.F. Farfan, Clin Orthop Relat Res 165, 110–123 (1982)Google Scholar
  3. 3.
    C.W. Pfirrmann, A. Metzdorf, M. Zanetti, J. Hodler, N. Boos, Spine (Phila Pa 1976) 26, 1873–1878 (2001)CrossRefGoogle Scholar
  4. 4.
    H. Takashima, T. Takebayashi, M. Yoshimoto, Y. Terashima, H. Tsuda, K. Ida, T. Yamashita, Skelet. Radiol. 41, 163–167 (2012)CrossRefGoogle Scholar
  5. 5.
    A. Watanabe, L.M. Benneker, C. Boesch, T. Watanabe, T. Obata, S.E. Anderson, AJR Am. J. Roentgenol. 189, 936–942 (2007)CrossRefGoogle Scholar
  6. 6.
    J. Antoniou, L.M. Epure, A.J. Michalek, M.P. Grant, J.C. Iatridis, F. Mwale, J. Magn. Reson. Imaging JMRI 38, 1402–1414 (2013)CrossRefGoogle Scholar
  7. 7.
    A.M. Nguyen, W. Johannessen, J.H. Yoder, A.J. Wheaton, E.J. Vresilovic, A. Borthakur, D.M. Elliott, J. Bone Jt. Surg. (American volume) 90, 796–802 (2008)CrossRefGoogle Scholar
  8. 8.
    A. Borthakur, P.M. Maurer, M. Fenty, C. Wang, R. Berger, J. Yoder, R.A. Balderston, D.M. Elliott, Spine 36, 2190–2196 (2011)CrossRefGoogle Scholar
  9. 9.
    X. Li, E.T. Han, C.B. Ma, T.M. Link, D.C. Newitt, S. Majumdar, Magn. Reson. Med. Off. J. Soc. Magn. Reson. Med Soc. Magn. Reson. Med. 54, 929–936 (2005)CrossRefGoogle Scholar
  10. 10.
    J. Oh, E.T. Han, D. Pelletier, S.J. Nelson, Magn. Reson. Imaging 24, 33–43 (2006)CrossRefGoogle Scholar
  11. 11.
    X. Li, C. Wyatt, J. Rivoire, E. Han, W. Chen, J. Schooler, F. Liang, K. Shet, R. Souza, S. Majumdar, J. Magn. Reson. Imaging 39, 1287–1293 (2014)CrossRefGoogle Scholar
  12. 12.
    Y. Takayama, M. Hatakenaka, T. Yoshiura, K. Okazaki, K. Nishikawa, T. Okuaki, I. Zimine, H. Honda, Magn. Reson. Med. Sci. 9, 209–215 (2010)CrossRefGoogle Scholar
  13. 13.
    F. Zhao, M. Deng, J. Yuan, G.J. Teng, A.T. Ahuja, Y.X. Wang, Korean J Radiol. 13, 736–742 (2012)CrossRefGoogle Scholar
  14. 14.
    P. Pandit, J.F. Talbott, V. Pedoia, W. Dillon, S. Majumdar, J. Orthop. Res. 34, 1373–1381 (2016)CrossRefGoogle Scholar
  15. 15.
    W. Chen, Quant. Imaging Med. Surg. 5, 583–591 (2015)Google Scholar
  16. 16.
    Y.X. Wang, Q. Zhang, X. Li, W. Chen, A. Ahuja, J. Yuan, Quant. Imaging Med. Surg. 5, 858–885 (2015)Google Scholar
  17. 17.
    G. Blumenkrantz, J. Zuo, X. Li, J. Kornak, T.M. Link, S. Majumdar, Magn. Reson. Med. 63, 1193–1200 (2010)CrossRefGoogle Scholar
  18. 18.
    R. Fleysher, L. Fleysher, O. Gonen, Magn. Reson. Imaging 26, 433–435 (2008)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Rui Imamura
    • 1
  • Hiroyuki Takashima
    • 1
    Email author
  • Mitsuhiro Nakanishi
    • 1
  • Yoshihiro Akatsuka
    • 1
  • Hiroshi Nagahama
    • 1
  • Tomoyuki Okuaki
    • 2
  • Masami Yoneyama
    • 2
  • Masamitsu Hatakenaka
    • 3
  1. 1.Division of Radiology and Nuclear MedicineSapporo Medical University HospitalSapporoJapan
  2. 2.Philips JapanTokyoJapan
  3. 3.Department of Diagnostic RadiologySapporo Medical University School of MedicineSapporoJapan

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