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Magic-Angle Spinning NMR and Molecular Mobility in Heterogeneous Systems

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Abstract

Magic-angle sample spinning (MAS) nuclear magnetic resonance (NMR) measurements are treated for heterogeneous systems with nanometer dimensions. An appreciable line narrowing in the MAS NMR spectra of the embedded molecules may be achieved also in the cases when the molecules still possess an appreciable local mobility. It appears that the MAS frequencies are of comparable order of magnitude as the frequencies which characterize the random molecular motional processes and which compete with MAS. It will be shown that this behavior may occur if inhomogeneous local magnetic fields due to susceptibility effects have a dominating influence on the widths and shapes of the resonance NMR lines. Properties of these local fields are described. Spectra simulations are carried for molecules embedded in these heterogeneous systems when the coherent averaging by MAS is superimposed by random local motions. This situation may occur for molecules contained in nanoporous solids and also for heterogeneous systems like membranes and biological tissues with flexible components like water, lipids, and small peptides. Several examples are treated which reveal advantages and limitations of these experiments and their theoretical interpretation.

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Acknowledgements

I thank Professor Juergen Haase (Leipzig University) for his permanent support, Professor Dieter Freude (Leipzig) for valuable comments, and Professor Vladimir I. Chizhik (St. Petersburg State University) for his great stimulation to prepare and publish this work. The good cooperation with Mrs. Dr. Özlen Ferruh Erdem (METU Ankara) and her contributions are kindly acknowledged.

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  1. Faculty of Physics and Earth Sciences, Leipzig University, Linné-Straße 5, 04103, Leipzig, Germany

    Dieter Michel

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  1. Dieter Michel
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Correspondence to Dieter Michel.

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Michel, D. Magic-Angle Spinning NMR and Molecular Mobility in Heterogeneous Systems. Appl Magn Reson 49, 537–552 (2018). https://doi.org/10.1007/s00723-018-0997-y

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  • DOI: https://doi.org/10.1007/s00723-018-0997-y

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