Applied Magnetic Resonance

, Volume 44, Issue 10, pp 1125–1138 | Cite as

Transmit-Only/Receive-Only Radiofrequency System for Hyperpolarized 13C MRS Cardiac Metabolism Studies in Pigs

  • G. Giovannetti
  • F. Frijia
  • V. Hartwig
  • L. Menichetti
  • V. Positano
  • J. H. Ardenkjaer-Larsen
  • V. Lionetti
  • G. D. Aquaro
  • D. De Marchi
  • R. F. Schulte
  • F. Wiesinger
  • L. Landini
  • M. Lombardi
  • M. F. Santarelli


Hyperpolarized 13C magnetic resonance spectroscopy in pig models enables metabolic activity mapping, providing a powerful tool for the study of the heart physiology, but requires the development of dedicated radiofrequency coils, capable of providing large field of view with high signal-to-noise ratio (SNR) data. This work describes the simulations and the tests of a transmit-only (TX) volume coil/receive-only (RX) surface coil both designed for hyperpolarized studies of pig heart with a clinical 3T scanner. The coil characterization is performed by developing an SNR model for coil performance in terms of coil resistance, sample-induced resistance and magnetic field pattern. In particular, coil resistances were calculated from Ohm’s law, while magnetic field patterns and sample-induced resistances were calculated using a numerical finite-difference time-domain algorithm. Experimental phantom chemical shift image, showed good agreement with the theoretical SNR-vs-depth profiles and highlighted the advantage of the novel configuration over the single transmit–receive coils throughout the volume of interest for cardiac imaging in pig. Finally, the TX-birdcage/RX-circular configuration was tested by acquiring metabolic maps with hyperpolarized [1-13C] pyruvate injected i.v. in a pig. The results of the phantom and pig experiments show the ability of the coil configuration to image well the metabolites distribution.


Surface Coil Dynamic Nuclear Polarization Chemical Shift Image Birdcage Coil Circular Coil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    U. Klose, F. Jiru, in Advanced Image Processing in Magnetic Resonance Imaging, ed. by L. Landini, V. Positano, M.F. Santarelli (Taylor & Francis, Boca Raton, 2005), pp 369–410Google Scholar
  2. 2.
    R.G. Shulman, D.L. Rothman, Annu. Rev. Physiol. 63, 15–48 (2001)CrossRefGoogle Scholar
  3. 3.
    A. Haase, F. Odoj, M. Von Kienlin, J. Warnking, F. Fidler, A. Weisser, M. Nittka, E. Rommel, T. Lanz, B. Kalusche, M Griswold, Concepts Magn. Reson. 12(6), 361–388 (2000)CrossRefGoogle Scholar
  4. 4.
    K. Golman, L.E. Olsson, O. Axelsson, S. Mansson, M. Karlsson, J.S. Petersson, Br. J. Radiol. 76, S118–S127 (2003)CrossRefGoogle Scholar
  5. 5.
    K. Golman, J.S. Petersson, P. Magnusson, E. Johansson, P. Akeson, C.M. Chai, G. Hansson, S. Mansson, Magn. Res. Med. 59, 1005–1013 (2008)CrossRefGoogle Scholar
  6. 6.
    S.E. Day, M.I. Kettunen, F.A. Gallagher, D.E. Hu, M. Lerche, J. Wolber, K. Golman, J.H. Ardenkjaer-Larsen, K.M. Brindle, Nat. Med. 13(11), 1382–1387 (2007)CrossRefGoogle Scholar
  7. 7.
    Y.F. Yen, S.J. Kohler, A.P. Chen, J. Tropp, R. Bok, J. Wolber, M.J. Albers, K.A. Gram, M.L. Zierhut, I. Park, V. Zhang, S. Hu, S.J. Nelson, D.B. Vigneron, J. Kurhanewicz, H.A.A.M. Dirven, R.E. Hurd, Magn. Res. Med. 62, 1–10 (2009)CrossRefGoogle Scholar
  8. 8.
    K. Derby, J. Tropp, C. Hawryszko, J. Magn. Reson. 86, 645–651 (1990)Google Scholar
  9. 9.
    M.A. Schroeder, H.J. Atherton, L.C. Heather, J.L. Griffin, K. Clarke, G.K. Radda, D.J. Tyler, NMR Biomed. 24, 980–987 (2011)CrossRefGoogle Scholar
  10. 10.
    A.Z. Lau, A.P. Chen, C.H. Cunningham, Magn. Res. Med. 67, 62–71 (2012)CrossRefGoogle Scholar
  11. 11.
    G. Giovannetti, F. Frijia, L. Menichetti, M. Milanesi, J.H. Ardenkjaer-Larsen, D. De Marchi, V. Hartwig, V. Positano, L. Landini, M. Lombardi, M.F. Santarelli, Med. Phys. 37(10), 5361–5369 (2010)CrossRefGoogle Scholar
  12. 12.
    G. Giovannetti, V. Hartwig, F. Frijia, L. Menichetti, V. Positano, J.H. Ardenkjaer-Larsen, V. Lionetti, G.D. Aquaro, D. De Marchi, A. Flori, L. Landini, M. Lombardi, M.F. Santarelli, App. Magn. Res. 42(3), 413–428 (2012)CrossRefGoogle Scholar
  13. 13.
    W. Dominguez-Viqueira, A.Z. Lau, A.P. Chen, C.H. Cunningham, Magn. Res. Med. 70(1), 295–300 (2013)Google Scholar
  14. 14.
    K.S. Yee, IEEE Trans. Ant. Propag. AP-14, 302–307 (1966)ADSGoogle Scholar
  15. 15.
    F. Frijia, L. Menichetti, V. Lionetti, M.F. Santarelli, J.H. Ardenkjaer-Larsen, G. Giovannetti, V. Positano, D. De Marchi, G. Aquaro, M. Campan, V. Hartwig, M. Milanesi, F.A. Recchia, L. Landini, M. Lombardi, J. Card. Magn. Res. 12(Supp 1), T14 (2010)CrossRefGoogle Scholar
  16. 16.
    L. Menichetti, F. Frijia, V. Lionetti, M.F. Santarelli, J.H. Ardenkjaer-Larsen, G. Giovannetti, V. Positano, D. De Marchi, G. Aquaro, M. Campan, V. Hartwig, M. Milanesi, F.A. Recchia, L. Landini, M. Lombardi, J. Cardiovasc. Magn. Reson. 12(Supp 1), T7 (2010)CrossRefGoogle Scholar
  17. 17.
    F. Frijia, L. Menichetti, V. Positano, V. Lionetti, C. Forte, J.H. Ardenkjaer-Larsen, M. Milanesi, G. Giovannetti, D.De Marchi, G. Aquaro, M. Campan, F.A. Recchia, L. Landini, M.F. Santarelli,. M. Lombardi, in Proceedings of ISMRM-ESMRMB, Stockholm, 2010Google Scholar
  18. 18.
    D.I. Hoult, R.E. Richards, J. Magn. Reson. 24, 71–85 (1976)Google Scholar
  19. 19.
    D.I. Hoult, P.C. Lauterbur, J. Magn. Reson. 34, 415–433 (1979)Google Scholar
  20. 20.
    N. Iriguchi, J. App. Phys. 73, 15–16 (1993)CrossRefGoogle Scholar
  21. 21.
    J. Wang, A. Reykowski, J. Dickas, IEEE Trans. Biomed. Eng. 42(9), 908–917 (1995)CrossRefGoogle Scholar
  22. 22.
    K. Ocegueda, A.O. Rodriguez, Conc Magn. Reson. Part A 28A(6), 422–429 (2006)CrossRefGoogle Scholar
  23. 23.
    J.P. Hornak, Encyclopedia of Imaging Science and Technology (Wiley, New York, 2002)CrossRefGoogle Scholar
  24. 24.
    J.L. Evelhoch, J.J.H. Ackerman, J. Magn. Reson. (1969) 53(1), 52–64 (1983)Google Scholar
  25. 25.
    G. Giovannetti, L. Landini, M.F. Santarelli, V. Positano, Magn Res Mat Phys Med Biol 15(1–3), 36–44 (2002)Google Scholar
  26. 26.
    D.I. Hoult, Conc. Magn. Reson. 12, 173–187 (2000)CrossRefGoogle Scholar
  27. 27.
    S.E. Hurlston, G.P. Cofer, G.A. Johnson, Int. J. Imaging Syst. Technol. 8, 277–284 (1997)CrossRefGoogle Scholar
  28. 28.
    W. Schnell, W. Renz, M. Vester, H. Ermert, IEEE Trans. Antennas Prop. 48(3), 418–428 (2000)ADSCrossRefGoogle Scholar
  29. 29.
    M.D. Harpen, Med. Phys. 14(4), 616–618 (1987)CrossRefGoogle Scholar
  30. 30.
    G. Giovannetti, V. Viti, Y. Liu, W. Yu, R. Mittra, L. Landini, A. Benassi, Conc. Magn. Reson. Part B 33B(4), 209–215 (2008)CrossRefGoogle Scholar
  31. 31.
    J. Jin, Electromagnetic Analysis and Design in Magnetic Resonance Imaging (CRC, Boca Raton, 1999)Google Scholar
  32. 32.
    G. Giovannetti, V. Viti, V. Positano, M.F. Santarelli, L. Landini, A. Benassi, Conc. Magn. Reson. Part B 31B(3), 140–146 (2007)CrossRefGoogle Scholar
  33. 33.
    H.C. Taylor, M. Burl, J.W. Hand, Phys. Med. Biol. 42, 1395–1402 (1997)CrossRefGoogle Scholar
  34. 34.
    K. Golman, J.S. Petersson, Acad. Radiol. 13, 932–942 (2006)CrossRefGoogle Scholar
  35. 35.
    J.H. Ardenkjaer-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M.H. Lerche, R. Servin, M. Thaning, K. Golman, Proc. Natl. Acad. Sci. USA. 100, 10158–10163 (2003)ADSCrossRefGoogle Scholar
  36. 36.
    M.V. Dutka, D. Bergin, P.L. O’Kane, A.J. Frangos, L. Parker, D.G. Mitchell, J. Magn. Reson. Imag. 27, 198–203 (2008)CrossRefGoogle Scholar
  37. 37.
    S.B. Reeder, A.R. Pineda, Z. Wen, A. Shimakawa, H. Yu, J.H. Brittain, G.E. Gold, C.H. Beaulieu, N.J. Pelc, Magn. Reson. Med. 54, 636–644 (2005)CrossRefGoogle Scholar
  38. 38.
    F. Wiesinger, E. Weidl, M.I. Menzel, M.A. Janich, O. Khegai, S.J. Glaser, A. Haase, M. Schwaiger, R.F. Schulte, Magn. Reson. Med. 68(1), 8–16 (2012)CrossRefGoogle Scholar
  39. 39.
    L. Darrasse, G. Kassab, Rev. Sci. Instrum. 64, 1841–1844 (1993)ADSCrossRefGoogle Scholar
  40. 40.
    S. Crozier, K. Luescher, L.K. Forbes, D.M. Doddrell, J. Magn. Reson. Ser. B 109, 1–11 (1995)CrossRefGoogle Scholar
  41. 41.
    U. Vovk, F. Pernus, B. Likar, IEEE Trans. Med. Imag. 26(3), 405–421 (2007)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • G. Giovannetti
    • 1
    • 2
  • F. Frijia
    • 2
  • V. Hartwig
    • 1
  • L. Menichetti
    • 1
    • 2
  • V. Positano
    • 2
    • 1
  • J. H. Ardenkjaer-Larsen
    • 3
    • 4
  • V. Lionetti
    • 5
  • G. D. Aquaro
    • 2
  • D. De Marchi
    • 2
  • R. F. Schulte
    • 6
  • F. Wiesinger
    • 6
  • L. Landini
    • 1
    • 2
    • 7
  • M. Lombardi
    • 2
  • M. F. Santarelli
    • 1
    • 2
  1. 1.National Council of ResearchInstitute of Clinical PhysiologyPisaItaly
  2. 2.Fondazione G. Monasterio CNR - Regione ToscanaPisaItaly
  3. 3.GE HealthcareBroendbyDenmark
  4. 4.Department of Electrical EngineeringTechnical University of DenmarkLyngbyDenmark
  5. 5.Laboratory of Medical ScienceInstitute of Life Sciences, Scuola Superiore S. AnnaPisaItaly
  6. 6.GE Global ResearchMunichGermany
  7. 7.Department of Information EngineeringUniversity of PisaPisaItaly

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