Applied Magnetic Resonance

, Volume 42, Issue 3, pp 343–352 | Cite as

Nontargeted NMR Analysis To Rapidly Detect Hazardous Substances in Alcoholic Beverages

  • Yulia B. Monakhova
  • Thomas Kuballa
  • Dirk W. Lachenmeier
Article

Abstract

Nuclear magnetic resonance spectroscopy is introduced for the analysis of alcoholic beverages in the context of governmental health and safety control. For sample preparation of all types of alcoholic beverages, only addition of buffer is required as single step. To detect potentially unsafe samples especially in the context of unrecorded alcohol (i.e., illegally or informally produced alcohol), a nontargeted approach based on principal component analysis (PCA) was applied. The PCA scores plot of 304 samples clearly shows seven conspicuous samples with highly divergent scores from the rest of the samples. These samples contained hazardous substances such as diethyl phthalate or polyhexamethyleneguanidine, as well as extremely high concentrations of methanol or ethyl carbamate. In addition to the nontargeted approach, partial least squares regression allowed us to quantify several parameters such as methanol, higher alcohols, 2-phenyl alcohol and ethyl acetate with high correlation to gas chromatographic reference analysis (R2 = 0.92−0.98).

References

  1. 1.
    D.W. Lachenmeier, S.G. Walch, W. Kessler, Eur. Food Res. Technol. 223, 261 (2006)CrossRefGoogle Scholar
  2. 2.
    D.W. Lachenmeier, E.-M. Sohnius, R. Attig, M.G. López, J. Agric. Food Chem. 54, 3911 (2006)CrossRefGoogle Scholar
  3. 3.
    D.W. Lachenmeier, W. Frank, T. Kuballa, Rapid Commun. Mass Spectrom. 19, 108 (2005)CrossRefGoogle Scholar
  4. 4.
    O.A. Kolomiets, D.W. Lachenmeier, U. Hoffmann, H.W. Siesler, J. Near Infrared Spectrosc. 18, 59 (2010)ADSCrossRefGoogle Scholar
  5. 5.
    F.D. Barboza, R.J. Poppi, Anal. Bioanal. Chem. 377, 695 (2003)CrossRefGoogle Scholar
  6. 6.
    D.W. Lachenmeier, Food Chem. 101, 825 (2007)CrossRefGoogle Scholar
  7. 7.
    Y.B. Monakhova, T. Kuballa, J. Leitz, D.W. Lachenmeier, Int. J. Anal. Chem. Article ID 704795 (2011)Google Scholar
  8. 8.
    G. Le Gall, I. J. Colquhoun, in Food authenticity and traceability, ed. by M. Lees, (Woodhead Publishing Ltd, Cambridge, 2003), p. 131Google Scholar
  9. 9.
    I. Duarte, A. Barros, P.S. Belton, R. Righelato, M. Spraul, E. Humpfer, A.M. Gil, J. Agric. Food Chem. 50, 2475 (2002)CrossRefGoogle Scholar
  10. 10.
    D.W. Lachenmeier, W. Frank, E. Humpfer, H. Schäfer, S. Keller, M. Mörtter, M. Spraul, Eur. Food Res. Technol. 220, 215 (2005)CrossRefGoogle Scholar
  11. 11.
    D.W. Lachenmeier, E. Humpfer, F. Fang, B. Schütz, P. Dvortsak, C. Sproll, M. Spraul, J. Agric. Food Chem. 57, 7194 (2009)CrossRefGoogle Scholar
  12. 12.
    Y.B. Monakhova, H. Schäfer, E. Humpfer, M. Spraul, T. Kuballa, D.W. Lachenmeier, Magn. Reson. Chem. 49, 734 (2011)Google Scholar
  13. 13.
    D.W. Lachenmeier, F. Kanteres, T. Kuballa, M.G. Lopez, J. Rehm, Int. J. Environ. Res. Public Health 6, 349 (2009)CrossRefGoogle Scholar
  14. 14.
    D.W. Lachenmeier, S. Ganss, B. Rychlak, J. Rehm, U. Sulkowska, M. Skiba, W. Zatonski, Alcohol. Clin. Exp. Res. 33, 1757 (2009)CrossRefGoogle Scholar
  15. 15.
    D.W. Lachenmeier, T. Kuballa, M.C.P. Lima, I.C.C. Nobrega, F. Kerr-Correa, F. Kanteres, J. Rehm, Deut. Lebensm. Rundsch. 105, 507 (2009)Google Scholar
  16. 16.
    F. Kanteres, D.W. Lachenmeier, J. Rehm, Addiction 104, 752 (2009)CrossRefGoogle Scholar
  17. 17.
    F. Kanteres, J. Rehm, D.W. Lachenmeier, Sci. Total Environ. 407, 5861 (2009)CrossRefGoogle Scholar
  18. 18.
    D.W. Lachenmeier, A.V. Samokhvalov, J. Leitz, K. Schoeberl, T. Kuballa, I.V. Linskiy, O.I. Minko, J. Rehm, Food Chem. Toxicol. 48, 2842 (2010)CrossRefGoogle Scholar
  19. 19.
    D.W. Lachenmeier, J. Leitz, K. Schoeberl, T. Kuballa, I. Straub, J. Rehm, Adicciones 23, 103 (2011)Google Scholar
  20. 20.
    D.W. Lachenmeier, B. Sarsh, J. Rehm, Alcohol Alcohol. 44, 93 (2009)Google Scholar
  21. 21.
    O.S. Ejim, B. Brands, J. Rehm, D.W. Lachenmeier, Afr. J. Drug Alcohol Stud. 6, 65 (2007)Google Scholar
  22. 22.
    P. Petrakis, I. Touris, M. Liouni, M. Zervou, I. Kyrikou, R. Kokkinofta, C.R. Theocharis, T.M. Mavromoustakos, J. Agric. Food Chem. 53, 5293 (2005)CrossRefGoogle Scholar
  23. 23.
    A. Nose, M. Hojo, M. Suzuki, T. Ueda, J. Agric. Food Chem. 52, 5359 (2004)CrossRefGoogle Scholar
  24. 24.
    N.P. Hu, D. Wu, K. Cross, S. Burikov, T. Dolenko, S. Patsaeva, D.W. Schaefer, J. Agric. Food Chem. 58, 7394 (2010)CrossRefGoogle Scholar
  25. 25.
    M. Guillou, C. Tellier, Anal. Chem. 60, 2182 (1988)CrossRefGoogle Scholar
  26. 26.
    Y.B. Monakhova, T. Kuballa, D.W. Lachenmeier, Int. J. Spectrosc. Article ID 171684 (2011)Google Scholar
  27. 27.
    P. Chandley, J. Near Infrared Spectrosc. 1, 133 (1993)ADSCrossRefGoogle Scholar
  28. 28.
    C.D. Patz, A. Blieke, R. Ristow, H. Dietrich, Anal. Chim. Acta 513, 81 (2004)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Yulia B. Monakhova
    • 1
    • 2
  • Thomas Kuballa
    • 1
  • Dirk W. Lachenmeier
    • 1
  1. 1.Chemisches und Veterinäruntersuchungsamt (CVUA) KarlsruheKarlsruheGermany
  2. 2.Department of ChemistrySaratov State UniversitySaratovRussia

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