Advertisement

Applied Magnetic Resonance

, Volume 34, Issue 3–4, pp 313–319 | Cite as

Principles of Operation of a DNP Prepolarizer Coupled to a Rodent MRI Scanner

  • A. Comment
  • B. van den Brandt
  • K. Uffmann
  • F. Kurdzesau
  • S. Jannin
  • J. A. Konter
  • P. Hautle
  • W. T. Wenckebach
  • R. Gruetter
  • J. J. van der Klink
Article

Abstract.

A dynamic nuclear polarization prepolarizer was developed and coupled to a 9.4 T rodent magnetic resonance imaging scanner in order to perform in vivo hyperpolarization experiments. In the present paper, emphasis is put on methods and hardware performance rather than on in vivo results obtained with this setup. An overview of the main hardware components is given. The full procedure starting from the sample preparation and solid-state polarization to in vivo infusion is described.

Keywords

Electron Spin Resonance Dynamic Nuclear Polarization Infusion Device Wide Electron Spin Resonance Line Saddle Coil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ardenkjaer-Larsen, J.H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M.H., Servin, R., Thaning, M., Golman, K.: Proc. Natl. Acad. Sci. USA 100, 10158–10163 (2003)CrossRefADSGoogle Scholar
  2. Comment, A., van den Brandt, B., Uffmann, K., Kurdzesau, F., Jannin, S., Konter, J.A., Hautle, P., Wenckebach, W.T., Gruetter, R., van der Klink, J.J.: Concepts Magn. Reson. 31B, 255–269 (2007)CrossRefGoogle Scholar
  3. Conradi, M.S.: Concepts Magn. Reson. 5, 243–262 (1993)CrossRefGoogle Scholar
  4. Ankel, E.G., Lai, C.-S., Hopwood, L.E., Zivkovic, Z.: Life Sci. 40, 495–498 (1987)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • A. Comment
    • 1
  • B. van den Brandt
    • 2
  • K. Uffmann
    • 3
  • F. Kurdzesau
    • 1
    • 2
  • S. Jannin
    • 1
  • J. A. Konter
    • 2
  • P. Hautle
    • 2
  • W. T. Wenckebach
    • 1
  • R. Gruetter
    • 3
  • J. J. van der Klink
    • 1
  1. 1.Laboratory for Physics of Nanostructured MaterialsÉcole Polytechnique Fédérale de LausanneLausanneSwitzerland
  2. 2.Paul Scherrer InstituteVilligenSwitzerland
  3. 3.Laboratory for Functional and Metabolic ImagingÉcole Polytechnique Fédérale de LausanneLausanneSwitzerland

Personalised recommendations