, Volume 253, Issue 2, pp 417–430 | Cite as

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

  • Mohammad Waseem
  • Suhel ParvezEmail author
Original Article


Peripheral neurotoxicity is one of the serious dose-limiting side effects of oxaliplatin (Oxa) when used in the treatment of malignant conditions. It is documented that it elicits major side effects specifically neurotoxicity due to oxidative stress forcing the patients to limit its clinical use in long-term treatment. Oxidative stress has been proven to be involved in Oxa-induced toxicity including neurotoxicity. The mitochondria have recently emerged as targets for anticancer drugs in various kinds of toxicity including neurotoxicity that can lead to neoplastic disease. However, there is paucity of literature involving the role of the mitochondria in mediating Oxa-induced neurotoxicity and its underlying mechanism is still debatable. The purpose of this study was to investigate the dose-dependent damage caused by Oxa on isolated brain mitochondria under in vitro conditions. The study was also designed to investigate the neuroprotective effects of nutraceuticals, curcumin (CMN), and quercetin (QR) on Oxa-induced mitochondrial oxidative stress and respiratory chain complexes in the brain of rats. Oxidative stress biomarkers, levels of nonenzymatic antioxidants, activities of enzymatic antioxidants, and mitochondrial complexes were evaluated against the neurotoxicity induced by Oxa. Pretreatment with CMN and QR significantly replenished the mitochondrial lipid peroxidation levels and protein carbonyl content induced by Oxa. CMN and QR ameliorated altered nonenzymatic and enzymatic antioxidants and complex enzymes of mitochondria. We conclude that CMN and QR, by attenuating oxidative stress as evident by mitochondrial dysfunction, hold promise as agents that can potentially reduce Oxa-induced adverse effects in the brain.


Anticancer drugs Natural compounds Mitochondrial complexes Oxidative stress Biomarkers 



The University Grants Commission (UGC), Government of India is gratefully acknowledged for providing funding under the Major Research Project Scheme (Grant No. 41-1286/2012-SR) awarded to Dr. Suhel Parvez. Mohd. Waseem was supported by a Senior Research Fellowship of UGC-Basic Science Research Scheme (Grant No. F-7/91/2007).

Conflict of interest

The authors declare that there is no conflict of interest.


  1. Al Moundhri MS, Al-Salam S, Al Mahrouqee A, Beegam S, Ali BH (2013) The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies. Med Toxicol 9:25–33CrossRefGoogle Scholar
  2. Ali BH (2009) Amelioration of oxaliplatin neurotoxicity by drugs in humans and experimental animals: a minireview of recent literature. Basic Clin Pharmacol Toxicol 106:272–279PubMedGoogle Scholar
  3. Alves E, Summavielle T, Alves CJ, Gomes-da-Silva J, Barata JC, Fernandes E, Bastos Mde L, Tavares MA, Carvalho F (2007) Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria. J Neurosci 27:10203–10210CrossRefPubMedGoogle Scholar
  4. Balayssac D, Ferrier J, Descoeur J, Ling B, Pezet D, Eschalier A, Authier N (2011) Chemotherapy-induced peripheral neuropathies: from clinical relevance to preclinical evidence. Expert Opin Drug Saf 10:407–417CrossRefPubMedGoogle Scholar
  5. Barbosa DJ, Capela JP, Oliveira JM, Silva R, Ferreira LM, Siopa F, Branco PS, Fernandes E, Duarte JA, de Lourdes Bastos M, Carvalho F (2012) Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes. Br J Pharmacol 165:1017–1033CrossRefPubMedPubMedCentralGoogle Scholar
  6. Barichello T, Savi GD, Simões LR, Generoso JS, Fraga DB, Bellettini G, Daufenbach JF, Rezin GT, Scaini G, Streck EL (2010) Evaluation of mitochondrial respiratory chain in the brain of rats after pneumococcal meningitis. Brain Res Bull 82:302–307CrossRefPubMedGoogle Scholar
  7. Barzegar A, Moosavi-Movahedi AA (2011) Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin. PLoS One 6, e26012CrossRefPubMedPubMedCentralGoogle Scholar
  8. Burgeiro A, Gajate C, Dakirel H, Villa-Pulgarín JA, Oliveira PJ, Mollinedo F (2011) Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells. Anticancer Drugs 22:507–518CrossRefPubMedGoogle Scholar
  9. Carrasco-Pozo C, Mizgier ML, Speisky H, Gotteland M (2012) Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chem Biol Interact 195:199–205CrossRefPubMedGoogle Scholar
  10. Chen YR, Chen CL, Zhang L, Green-Church KB, Zweier JL (2005) Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation. J Biol Chem 280:37339–37348CrossRefPubMedGoogle Scholar
  11. Ciftci O, Ozdemir I, Vardi N, Beytur A, Oguz F (2012) Ameliorating effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced nephrotoxicity in rats. Toxicol Ind Health 28:947–954CrossRefPubMedGoogle Scholar
  12. Correi SC, Carvalho C, Cardoso S, Santos RX, Santos MS, Oliveira CR, Perry G, Zhu X, Smith MA, Moreira PI (2010) Mitochondrial preconditioning: a potential neuroprotective strategy. Front Aging Neurosci 2:138Google Scholar
  13. Dai X, Ding Y, Zhang Z, Cai X, Li Y (2013) Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F ß-cells via the mitochondrial pathway and NF-κB signaling. Int J Mol Med 31:265–271PubMedGoogle Scholar
  14. Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R (2003) Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 329:23–38CrossRefPubMedGoogle Scholar
  15. Dharap SS, Wang Y, Chandna P, Khandare JJ, Qiu B, Gunaseelan S, Sinko PJ, Stein S, Farmanfarmaian A, Minko T (2005) Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc Natl Acad Sci 102:12962–12967CrossRefPubMedPubMedCentralGoogle Scholar
  16. Di Cesare Mannelli L, Zanardelli M, Failli P, Ghelardini C (2012) Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. J Pain 13:276–284CrossRefPubMedGoogle Scholar
  17. Erkurt MA, Aydogdu I, Kuku I, Kaya E, Ozhan O (2008) Anticancer induced glomerular dysfunction. World J Med Sci 3:5–9Google Scholar
  18. Fiorani M, Guidarelli A, Blasa M, Azzolini C, Candiracci M, Piatti E, Cantoni O (2010) Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid. J Nutr Biochem 21:397–404CrossRefPubMedGoogle Scholar
  19. Floor E, Wetzel MG (1998) Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhydrazine assay. J Neurochem 70:268–275CrossRefPubMedGoogle Scholar
  20. Florea AM, Büsselberg D (2011) Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers 3:1351–1371CrossRefPubMedPubMedCentralGoogle Scholar
  21. Garcia J, Han D, Sancheti H, Yap LP, Kaplowitz N, Cadenas E (2010) Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem 285:39646–39654CrossRefPubMedPubMedCentralGoogle Scholar
  22. Ghezzi P, Romines B, Fratelli M, Eberini I, Gianazza E, Casagrande S, Laragione T, Mengozzi M, Herzenberg LA (2002) Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection. Mol Immunol 38:773–780CrossRefPubMedGoogle Scholar
  23. González-Salazar A, Molina-Jijón E, Correa F, Zarco-Márquez G, Calderón-Oliver M, Tapia E, Zazueta C, Pedraza-Chaverri J (2011) Curcumin protects from cardiac reperfusion damage by attenuation of oxidant stress and mitochondrial dysfunction. Cardiovasc Toxicol 11:357–364CrossRefPubMedGoogle Scholar
  24. Govil N, Chaudhary S, Waseem M, Parvez S (2012) Postnuclear supernatant: an in vitro model for assessing cadmium-induced neurotoxicity. Biol Trace Elem Res 146:402–409CrossRefPubMedGoogle Scholar
  25. Guangwei X, Rongzhu L, Wenrong X, Suhua W, Xiaowu Z, Shizhong W, Ye Z, Aschner M, Kulkarni SK, Bishnoi M (2010) Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology 267:140–146CrossRefPubMedGoogle Scholar
  26. Habig WH, Pabst M, Jaoby WB (1974) Glutathione S-transferase: the first step in mercapturic acid formation. J Biol Chem 249:7130–7139PubMedGoogle Scholar
  27. Haleagrahara N, Siew CJ, Ponnusamy K (2013) Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats. J Toxicol Sci 38:25–33CrossRefPubMedGoogle Scholar
  28. Haque R, Bin-Hafeez B, Parvez S, Pandey S, Sayeed I, Ali M, Raisuddin S (2003) Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide induced biochemical toxicity. Hum Exp Toxicol 22:473–480CrossRefPubMedGoogle Scholar
  29. He P, Ahn JC, Shin JI, Chung PS (2010) Photoactivation of 9-hydroxypheophorbide alpha triggers apoptosis through the reactive oxygen species-mediated mitochondrial pathway and endoplasmic reticulum stress in AMC-HN-3 laryngeal cancer cells. Int J Oncol 36:801–818PubMedGoogle Scholar
  30. Holt A, Sharman DF, Baker GB, Palcic MM (1997) A continuous spectrophotometric assay for monoamine oxidase and related enzymes in tissue homogenates. Anal Biochem 244:384–392CrossRefPubMedGoogle Scholar
  31. Huang T, Gong WH, Li XC, Zou CP, Jiang GJ, Li XH, Qian H (2012) Oxaliplatin sensitizes OS cells to TRAIL-induced apoptosis via down-regulation of Mcl1. Asian Pac J Cancer Prev 13:3477–3481CrossRefPubMedGoogle Scholar
  32. Ilhan-Mutlu A, Preusser M, Schoppmann SF, Asari R, Ba-Ssalamah A, Schwameis K, Pluschnig U, Birner P, Püspök A, Zacherl J, Hejna M (2013) Comparison between DCF (Docetaxel, Cisplatin and 5-Fluorouracil) and modified EOX (Epirubicin, Oxaliplatin and Capecitabine) as palliative first-line chemotherapy for adenocarcinoma of the upper gastrointestinal tract. Anticancer Res 33:3455–3459PubMedGoogle Scholar
  33. Iwata T, Nishiyama N, Nagano K, Izumi N, Mizuguchi S, Tsukioka T, Morita R, Chung K, Hanada S, Inoue K (2012) Role of pulmonary resection in the diagnosis and treatment of limited-stage small cell lung cancer: revision of clinical diagnosis based on findings of resected specimen and its influence on survival. Gen Thorac Cardiovasc Surg 60:43–52CrossRefPubMedGoogle Scholar
  34. Jaggi AS, Singh N (2012) Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology 291:1–9CrossRefPubMedGoogle Scholar
  35. Jakubowicz-Gil J, Langner E, Wertel I, Piersiak T, Rzeski W (2010) Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line. Chem Biol Interact 188(1):190–203CrossRefPubMedGoogle Scholar
  36. Kagiava A, Tsingotjidou A, Emmanouilides C, Theophilidis G (2008) The effects of oxaliplatin, an anticancer drug, on potassium channels of the peripheral myelinated nerve fibres of the adult rat. Neurotoxicology 29:1100–1106CrossRefPubMedGoogle Scholar
  37. Kahraman A, Çakar H, Köken T (2012) The protective effect of quercetin on long-term alcohol consumption-induced oxidative stress. Mol Biol Rep 39:2789–2794CrossRefPubMedGoogle Scholar
  38. Kallio J, Jaakkola M, Mäki M, Kilpeläinen P, Virtanen V (2012) Vitamin C inhibits staphylococcus aureus growth and enhances the inhibitory effect of quercetin on growth of Escherichia coli in vitro. Planta Med 78:1824–1830CrossRefPubMedGoogle Scholar
  39. Kamboj SS, Sandhir R (2011) Protective effect of N-acetylcysteine supplementation on mitochondrial oxidative stress and mitochondrial enzymes in cerebral cortex of streptozotocin-treated diabetic rats. Mitochondrion 11:214–222CrossRefPubMedGoogle Scholar
  40. Kanbagli O, Balkan J, Aykaç-Toker G, Uysal M (2002) Hepatic mitochondrial prooxidant and antioxidant status in ethanol-induced liver injury in rats. Biol Pharm Bull 25:1482–1484CrossRefPubMedGoogle Scholar
  41. Karuppagounder SS, Madathil SK, Pandey M, Haobam R, Rajamma U, Mohanakumar KP (2013) Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson’s disease in rats. Neuroscience 236:136–148CrossRefPubMedGoogle Scholar
  42. King TE (1967) Preparation of succinate dehydrogenase and reconstitution of reconstitution of succinate oxidase. Methods Enzymol 10:322–331CrossRefGoogle Scholar
  43. King TE, Howard RL (1967) Preparations and properties of soluble NADH dehydrogenases from cardiac muscle. Methods Enzymol 10:275–284CrossRefGoogle Scholar
  44. Kluth D, Banning A, Paur I, Blomho VR, Brigelius-Flohe R (2007) Modulation of pregnane X receptor and electrophile responsive element-mediated gene expression by dietary polyphenolic compound. Free Radic Biol Med 42:315–325CrossRefPubMedGoogle Scholar
  45. Kupsch K, Parvez S, Siemen D, Wolf G (2007) Modulation of the permeability transition pore by inhibition of the mitochondrial K(ATP) channel in liver vs. brain mitochondria. J Membr Biol 215:69–74CrossRefPubMedGoogle Scholar
  46. Lee CS, Kwak SW, Kim YJ, Lee SA, Park ES, Myung SC, Kim W, Lee MS, Lee JJ (2012a) Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways. Eur J Pharmacol 683:54–62CrossRefPubMedGoogle Scholar
  47. Lee JS, Kim YT, Jeon EK, Won HS, Cho YS, Ko YH (2012b) Effect of green tea extracts on oxaliplatin-induced peripheral neuropathy in rats. BMC Complement Altern Med 12:124CrossRefPubMedPubMedCentralGoogle Scholar
  48. Li L, Zhang B, Tao Y, Wang Y, Wei H, Zhao J, Huang R, Pei Z (2009) DL-3-n-butylphthalide protects endothelial cells against oxidative/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose deprivation in vitro. Brain Res 22:91–101CrossRefGoogle Scholar
  49. Lim SC, Choi JE, Kang HS, Han SI (2010) Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma. Int J Cancer 126(7):1582–1595PubMedGoogle Scholar
  50. Ling B, Peng F, Alcorn J, Lohmann K, Bandy B, Zello GA (2012) D-Lactate altered mitochondrial energy production in rat brain and heart but not liver. Nutr Metab (Lond) 9:6CrossRefGoogle Scholar
  51. López-Jornet P, Camacho-Alonso F, Gómez-Garcia F (2011) Effect of curcumin and irradiation in PE/CA-PJ15 oral squamous cell carcinoma. Acta Odontol Scand 69:269–273CrossRefPubMedGoogle Scholar
  52. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275PubMedGoogle Scholar
  53. Luo T, Yu J, Nguyen J, Wang CR, Bristow RG, Jaffray DA, Zhou XZ, Lu KP, Lu QB (2012) Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers. Proc Natl Acad Sci U S A 109:10175–10180CrossRefPubMedPubMedCentralGoogle Scholar
  54. Maggioni D, Nicolini G, Chiorazzi A, Meregalli C, Cavaletti G, Tredici GJ (2010) Different effects of erythropoietin in cisplatin- and docetaxel-induced neurotoxicity: an in vitro study. Neurosci Res 88:3171–3179CrossRefGoogle Scholar
  55. Martínez-Morúa A, Soto-Urquieta MG, Franco-Robles E, Zúñiga-Trujillo I, Campos-Cervantes A, Pérez-Vázquez V, Ramírez-Emiliano J (2013) Curcumin decreases oxidative stress in mitochondria isolated from liver and kidneys of high-fat diet-induced obese mice. J Asian Nat Prod Res 15:905–915CrossRefPubMedGoogle Scholar
  56. Mastrocola R, Restivo F, Vercellinatto I, Danni O, Brignardello E, Aragno M, Boccuzzi G (2005) Oxidative and nitrosative stress in brain mitochondria of diabetic rats. J Endocrinol 187:37–44CrossRefPubMedGoogle Scholar
  57. Matouk AI, Taye A, Heeba GH, El-Moselhy MA (2013) Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats. Environ Toxicol Pharmacol 36(2):443–450CrossRefPubMedGoogle Scholar
  58. Mehndiratta MM, Agarwal P, Tatke M, Krishnamurthy M (2000) Neurological mitochondrial cytopathies. Neurol India 50:162–167Google Scholar
  59. Mishra S, Palanivelu K (2008) The effect of curcumin (turmeric) on Alzheimer’s disease: an overview. Ann Indian Acad Neurol 11:13–19CrossRefPubMedPubMedCentralGoogle Scholar
  60. Mruk DD, Silvestrini B, Mo MY, Cheng CY (2002) Antioxidant superoxide dismutase—a review: its function, regulation in the testis, and role in male fertility. Contraception 65:305–311CrossRefPubMedGoogle Scholar
  61. Nabavi SF, Moghaddam AH, Eslami S, Nabavi SM (2012) Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys. Biol Trace Elem Res 145:369–374CrossRefPubMedGoogle Scholar
  62. Pandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Med Cell Longev 2:270–278CrossRefGoogle Scholar
  63. Parvez S, Raisuddin S (2006) Preexposure to copper modulates nonenzymatic antioxidants in liver of Channa punctata (Bloch) exposed to the herbicide paraquat. Bull Environ Contam Toxicol 76:545–551CrossRefPubMedGoogle Scholar
  64. Parvez S, Tabassum H, Banerjee BD, Raisuddin S (2008) Taurine prevents tamoxifen-induced mitochondrial oxidative damage in mice. Basic Clin Pharmacol Toxicol 102:382–387CrossRefPubMedGoogle Scholar
  65. Qian Y, Guan T, Huang M, Cao L, Li Y, Cheng H, Jin H, Yu D (2012) Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NFκ-B activation in a cerebral ischemia mouse model. Neurochem Int 60:759–767CrossRefPubMedGoogle Scholar
  66. Raschi E, De Ponti F (2012) Cardiovascular toxicity of anticancer-targeted therapy: emerging issues in the era of cardio-oncology. Intern Emerg Med 7:113–131CrossRefPubMedGoogle Scholar
  67. Raza H, John A, Benedict S (2011) Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells. Eur J Pharmacol 668:15–24CrossRefPubMedGoogle Scholar
  68. Ren SC, Suo QF, Du WT, Pan H, Yang MM, Wang RH, Liu J (2010) Quercetin permeability across blood-brain barrier and its effect on the viability of U251 cells. Sichuan Da Xue Xue Bao Yi Xue Ban 41:751–759PubMedGoogle Scholar
  69. Rezvanfar MA, Farshid AA, Sadrkhanlou RA, Ahmadi A, Rezvanfar MA, Salehnia A, Abdollahi M (2010) Benefit of Satureja khuzestanica in subchronically rat model of cyclophosphamide-induced hemorrhagic cystitis. Exp Toxicol Pathol 62:323–330CrossRefPubMedGoogle Scholar
  70. Rinne ML, Lee EQ, Wen PY (2012) Central nervous system complications of cancer therapy. J Support Oncol 10:133–141CrossRefPubMedGoogle Scholar
  71. Rodriguez-Menendez V, Gilardini A, Bossi M, Canta A, Oggioni N, Carozzi V, Tremolizzo L, Cavaletti G (2008) Valproate protective effects on cisplatin-induced peripheral neuropathy: an in vitro and in vivo study. Anticancer Res 28:335–342PubMedGoogle Scholar
  72. Sakurai M, Egashira N, Kawashiri T, Yano T, Ikesue H, Oishi R (2009) Oxaliplatin-induced neuropathy in the rat: involvement of oxalate in cold hyperalgesia but not mechanical allodynia. Pain 147:165–174CrossRefPubMedGoogle Scholar
  73. Sandoval-Acuña C, Lopez-Alarcón C, Aliaga ME, Speisky H (2012) Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action. Chem Biol Interact 199:18–28CrossRefPubMedGoogle Scholar
  74. Sarkar FH, Li Y, Wang Z, Padhye S (2010) Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs. Curr Pharm Des 16:1801–1812CrossRefPubMedPubMedCentralGoogle Scholar
  75. Sekaran S, Kandaswamy S, Gunasekaran K, Perumal E, Afsar Basha FY, Madhan Mohan BJ, Jagadeesan A (2012) Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. J Biochem Mol Toxicol 26:522–532CrossRefPubMedGoogle Scholar
  76. Singh R, Sharma P (2011) Hepatoprotective effect of curcumin on lindane-induced oxidative stress in male Wistar rats. Toxicol Int 18:124–129CrossRefPubMedPubMedCentralGoogle Scholar
  77. Sivalingam N, Basivireddy J, Balasubramanian KA, Jacob M (2008) Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. Arch Toxicol 82:471–481CrossRefPubMedGoogle Scholar
  78. Sood PK, Nahar U, Nehru B (2011) Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain. Neurotox Res 20:351–361CrossRefPubMedGoogle Scholar
  79. Soto-Otero R, Méndez-Alvarez E, Hermida-Ameijeiras A, Sánchez-Sellero I, Cruz-Landeira A, Lamas ML (2001) Inhibition of brain monoamine oxidase activity by the generation of hydroxyl radicals: potential implications in relation to oxidative stress. Life Sci 69:879–889CrossRefPubMedGoogle Scholar
  80. Su Y, Sun H, Fang J, Hu G, Xiao M (2010) Brain mitochondrial dysfunction in ovariectomized mice injected with D-galactose. Neurochem Res 35:399–404CrossRefPubMedGoogle Scholar
  81. Swamy AV, Gulliaya S, Thippeswamy A, Koti BC, Manjula DV (2012) Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharm 44:73–77CrossRefGoogle Scholar
  82. Tabassum H, Parvez S, Rehman H, Banerjee BD, Raisuddin S (2007) Catechin as an antioxidant in liver mitochondrial toxicity: inhibition of tamoxifen-induced protein oxidation and lipid peroxidation. J Biochem Mol Toxicol 21:110–117CrossRefPubMedGoogle Scholar
  83. Tabassum H, Parvez S, Pasha ST, Banerjee BD, Raisuddin S (2010) Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria. Food Chem Toxicol 48:1973–1979CrossRefPubMedGoogle Scholar
  84. Tang Y, Gao C, Xing M, Li Y, Zhu L, Wang D, Yang X, Liu L, Yao P (2012) Quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative damage. Food Chem Toxicol 50:1194–1200CrossRefPubMedGoogle Scholar
  85. Toshiyuki S, Kaori K, Yasushi O (2011) Adverse event profiles of platinum agents: data mining of the public version of the FDA adverse event reporting system, AERS, and reproducibility of clinical observations. Int J Med Sci 8:487–491Google Scholar
  86. Townsend DM, Tew KD (2003) The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22:7369–7375CrossRefPubMedGoogle Scholar
  87. Tucci P, Cione E, Perri M, Genchi G (2008) All-trans-retinoic acid induces apoptosis in Leydig cells via activation of the mitochondrial death pathway and antioxidant enzyme regulation. J Bioenerg Biomembr 40:315–323CrossRefPubMedGoogle Scholar
  88. Valenti D, De Rasmo D, Signorile A, Rossi L, de Bari L, Scala I, Granese B, Papa S, Vacca RA (2013) Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down’s syndrome. Biochim Biophys Acta 1832:542–552CrossRefPubMedGoogle Scholar
  89. Wang ME, Chen YC, Chen IS, Hsieh SC, Chen SS, Chiu CH (2012) Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. J Nutr Biochem 35:1352–1366CrossRefGoogle Scholar
  90. Waseem M, Parvez S (2013) Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin. Food Chem Toxicol 53:334–342CrossRefPubMedGoogle Scholar
  91. Xiao WH, Bennett GJ (2012) Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin. Pain 153:704–709CrossRefPubMedPubMedCentralGoogle Scholar
  92. Yadav RS, Chandravanshi LP, Shukla RK, Sankhwar ML, Ansari RW, Shukla PK, Pant AB, Khanna VK (2011) Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats. Neurotoxicology 32:760–768CrossRefPubMedGoogle Scholar
  93. Yoshino S, Hara A, Sakakibara H, Kawabata K, Tokumura A, Ishisaka A, Kawai Y, Terao J (2011) Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria. Nutrition 27:847–852CrossRefPubMedGoogle Scholar
  94. Youn H, Jeong JC, Jeong YS, Kim EJ, Um SJ (2013) Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Boil Pharm Bull 36(6):944–951CrossRefGoogle Scholar
  95. Zhang X, Yeung ED, Wang J, Panzhinskiy EE, Tong C, Li W, Li J (2010) Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. Clin Exp Pharmacol Physiol 37:841–847PubMedGoogle Scholar
  96. Zheng H, Xiao WH, Bennett GJ (2012) Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. Exp Neurol 238:225–234CrossRefPubMedGoogle Scholar
  97. Zhu YG, Chen XC, Chen ZZ, Zeng YQ, Shi GB, Su YH, Peng X (2004) Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons. Acta Pharmacol Sin 25:1606–1612PubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.Department of Medical Elementology and ToxicologyJamia Hamdard (Hamdard University)New DelhiIndia

Personalised recommendations