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Protoplasma

, Volume 253, Issue 2, pp 417–430 | Cite as

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

  • Mohammad Waseem
  • Suhel ParvezEmail author
Original Article

Abstract

Peripheral neurotoxicity is one of the serious dose-limiting side effects of oxaliplatin (Oxa) when used in the treatment of malignant conditions. It is documented that it elicits major side effects specifically neurotoxicity due to oxidative stress forcing the patients to limit its clinical use in long-term treatment. Oxidative stress has been proven to be involved in Oxa-induced toxicity including neurotoxicity. The mitochondria have recently emerged as targets for anticancer drugs in various kinds of toxicity including neurotoxicity that can lead to neoplastic disease. However, there is paucity of literature involving the role of the mitochondria in mediating Oxa-induced neurotoxicity and its underlying mechanism is still debatable. The purpose of this study was to investigate the dose-dependent damage caused by Oxa on isolated brain mitochondria under in vitro conditions. The study was also designed to investigate the neuroprotective effects of nutraceuticals, curcumin (CMN), and quercetin (QR) on Oxa-induced mitochondrial oxidative stress and respiratory chain complexes in the brain of rats. Oxidative stress biomarkers, levels of nonenzymatic antioxidants, activities of enzymatic antioxidants, and mitochondrial complexes were evaluated against the neurotoxicity induced by Oxa. Pretreatment with CMN and QR significantly replenished the mitochondrial lipid peroxidation levels and protein carbonyl content induced by Oxa. CMN and QR ameliorated altered nonenzymatic and enzymatic antioxidants and complex enzymes of mitochondria. We conclude that CMN and QR, by attenuating oxidative stress as evident by mitochondrial dysfunction, hold promise as agents that can potentially reduce Oxa-induced adverse effects in the brain.

Keywords

Anticancer drugs Natural compounds Mitochondrial complexes Oxidative stress Biomarkers 

Notes

Acknowledgments

The University Grants Commission (UGC), Government of India is gratefully acknowledged for providing funding under the Major Research Project Scheme (Grant No. 41-1286/2012-SR) awarded to Dr. Suhel Parvez. Mohd. Waseem was supported by a Senior Research Fellowship of UGC-Basic Science Research Scheme (Grant No. F-7/91/2007).

Conflict of interest

The authors declare that there is no conflict of interest.

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© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.Department of Medical Elementology and ToxicologyJamia Hamdard (Hamdard University)New DelhiIndia

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