, Volume 250, Issue 5, pp 965–983 | Cite as

CEP proteins: the knights of centrosome dynasty

  • Ambuj Kumar
  • Vidya Rajendran
  • Rao Sethumadhavan
  • Rituraj Purohit
Review Article


Centrosome forms the backbone of cell cycle progression mechanism. Recent debates have occurred regarding the essentiality of centrosome in cell cycle regulation. CEP family protein is the active component of centrosome and plays a vital role in centriole biogenesis and cell cycle progression control. A total of 31 proteins have been categorized into CEP family protein category and many more are under candidate evaluation. Furthermore, by the recent advancements in genomics and proteomics researches, several new CEP proteins have also been characterized. Here we have summarized the importance of CEP family proteins and their regulation mechanism involved in proper cell cycle progression. Further, we have reviewed the detailed molecular mechanism behind the associated pathological phenotypes and the possible therapeutic approaches. Proteins such as CEP57, CEP63, CEP152, CEP164, and CEP215 have been extensively studied with a detailed description of their molecular mechanisms, which are among the primary targets for drug discovery. Moreover, CEP27, CEP55, CEP70, CEP110, CEP120, CEP135, CEP192, CEP250, CEP290, and CEP350 also seem promising for future drug discovery approaches. Since the overview implicates that the overall researches on CEP proteins are not yet able to present significant details required for effective therapeutics development, thus, it is timely to discuss the importance of future investigations in this field.


CEP family Centrosomes Centrioles Cancer Primary microcephaly 



We gratefully acknowledge the management of Vellore Institute of Technology University for providing the facilities to carry out this work. We thank the anonymous reviewers for their helpful comments and critical reading of the manuscript.

Conflict of interest

The authors have no potential conflict of interest to disclose.


  1. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (2003) Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426:570–574PubMedCrossRefGoogle Scholar
  2. Baron DM, Ralston KS, Kabututu ZP, Hill KL (2007) Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella. J Cell Sci 120:478–491PubMedCrossRefGoogle Scholar
  3. Barr AR et al (2010) CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. J Cell Biol 189:23–39PubMedCrossRefGoogle Scholar
  4. Basto R et al (2008) Centrosome amplification can initiate tumorigenesis in flies. Cell 133:1032–1042PubMedCrossRefGoogle Scholar
  5. Bond J et al (2005) A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nat Genet 37:353–355PubMedCrossRefGoogle Scholar
  6. Bossard C, Laurell H, Van den Berghe L, Meunier S, Zanibellato C, Prats H (2003) Translokin is an intracellular mediator of FGF-2 trafficking. Nat Cell Biol 5:433–439PubMedCrossRefGoogle Scholar
  7. Broadhead R et al (2006) Flagellar motility is required for the viability of the bloodstream trypanosome. Nature 2006(440):224–227CrossRefGoogle Scholar
  8. Buim ME, Soares FA, Sarkis AS, Nagai MA (2005) The transcripts of SFRP1, CEP63 and EIF4G2 genes are frequently downregulated in transitional cell carcinomas of the bladder. Oncology 69:445–454PubMedCrossRefGoogle Scholar
  9. Castellanos E et al (2008) Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol 18:1209–1214PubMedCrossRefGoogle Scholar
  10. Chen N et al (2006) Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics. Genome Biol 7:R126PubMedCrossRefGoogle Scholar
  11. Choi Y et al (2010) CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex. J Cell Biol 191:1089–1095PubMedCrossRefGoogle Scholar
  12. Cizmecioglu O et al (2010) Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. J Cell Biol 191:731–739PubMedCrossRefGoogle Scholar
  13. Cooper CD et al (2011) Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. PLoS One 6:e23916Google Scholar
  14. Dobbelaere J, Josue F, Suijkerbuijk S, Baum B, Tapon N, Raff J (2008) A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila. PLoS Biol 6:e224PubMedCrossRefGoogle Scholar
  15. Duensing A, Ghanem L, Steinman RA, Liu Y, Duensing S (2006) p21(Waf1/Cip1) deficiency stimulates centriole overduplication. Cell Cycle 5:2899–2902PubMedCrossRefGoogle Scholar
  16. Duensing A et al (2008) Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms. Virology 372:157–164PubMedCrossRefGoogle Scholar
  17. Dzhindzhev NS et al (2010) Asterless is a scaffold for the onset of centriole assembly. Nature 467:714–718PubMedCrossRefGoogle Scholar
  18. Edde B, Rossier J, Le Caer JP, Desbruyeres E, Gros F, Denoulet P (1990) Posttranslational glutamylation of alpha-tubulin. Science 247:83–85PubMedCrossRefGoogle Scholar
  19. Emanuele MJ, Stukenberg PT (2007) Xenopus Cep57 Is a novel kinetochore component involved in microtubule attachment. Cell 130:893–905PubMedCrossRefGoogle Scholar
  20. Fabro M et al (2005) Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell 9:477–488CrossRefGoogle Scholar
  21. Fong KW, Choi YK, Rattner JB, Qi RZ (2008) CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the g-tubulin ring complex. Mol Biol Cell 19:115–125PubMedCrossRefGoogle Scholar
  22. Fuchs F et al (2010) Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol 6:370PubMedCrossRefGoogle Scholar
  23. Gemenetzidis E et al (2009) FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One 4(3):e4849PubMedCrossRefGoogle Scholar
  24. Gergely F, Basto R (2008) Multiple centrosomes: together they stand, divided they fall. Genes Dev 22:2291–2296PubMedCrossRefGoogle Scholar
  25. Glazer DS, Radmer RJ, Altman RB (2009) Improving structure-based function prediction using molecular dynamics. Structure 17:919–929PubMedCrossRefGoogle Scholar
  26. Gonzalez C (2008) Centrosome function during stem cell division: the devil is in the details. Curr Opin Cell Biol 20:694–698PubMedCrossRefGoogle Scholar
  27. Goshima G, Wollman R, Goodwin SS, Zhang N, Scholey JM, Vale RD, Stuurman N (2007) Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316:417–421PubMedCrossRefGoogle Scholar
  28. Graser S et al (2007a) Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. J Cell Sci 120:4321–4331PubMedCrossRefGoogle Scholar
  29. Graser S et al (2007b) Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol 179:321–330PubMedCrossRefGoogle Scholar
  30. Guarguaglini G et al (2005) The forkhead-associated domain protein Cep170 interacts with polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell 16:1095–1107PubMedCrossRefGoogle Scholar
  31. Guernsey DL et al (2010) Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Am J Hum Genet 87:40–51PubMedCrossRefGoogle Scholar
  32. Guerrier S, Polleux F (2007) The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration. Neuron 56:1–3PubMedCrossRefGoogle Scholar
  33. Guo HQ et al (2007) Analysis of the cellular centrosome in fine-needle aspirations of the breast. Breast Canc Res 9:R48CrossRefGoogle Scholar
  34. Habermann K, Lange BM (2012) New insights into subcomplex assembly and modifications of centrosomal proteins. Cell Div 7(1):17Google Scholar
  35. Hassan MJ, Chishti MS, Jamal SM, Tariq M, Ahmad W (2008) A syndromic form of autosomal recessive congenital microcephaly (Jawad syndrome) maps to chromosome 18p11.22-q11.2. Hum Genet 123:77–82PubMedCrossRefGoogle Scholar
  36. Hensel M et al (2007) High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukemia. Int J Cancer 121:978–983PubMedCrossRefGoogle Scholar
  37. Hinchcliffe EH, Sluder G (2001) “It takes two to tango”: understanding how centrosome duplication is regulated throughout the cell cycle. Genes Dev 15:1167–1181PubMedCrossRefGoogle Scholar
  38. Hoppeler-Lebel A et al (2007) Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex. J Cell Sci 120:3299–3308PubMedCrossRefGoogle Scholar
  39. Hussain MS et al (2012) A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function. Am J Hum Genet 90:871–878PubMedCrossRefGoogle Scholar
  40. Ibañez-Tallon I, Heintz N, Omran H (2003) To beat or not to beat: roles of cilia in development and disease. Hum Mol Genet 12:R27–R35PubMedCrossRefGoogle Scholar
  41. Innocent P et al (2012) Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure–activity relationship, structural biology, and cellular activity. J Med Chem 5:3228–3241CrossRefGoogle Scholar
  42. Inoda S et al (2009) Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. J Immunother 32:474–485PubMedCrossRefGoogle Scholar
  43. Inoda S et al (2011) The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. Exp Mol Pathol 90:55–60PubMedCrossRefGoogle Scholar
  44. Iwamori T et al (2010) TEX14 interacts with CEP55 to block cell abscission. Mol Cell Biol 30:2280–2292PubMedCrossRefGoogle Scholar
  45. Jakobsen L et al (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J 30(8):1520–1535PubMedCrossRefGoogle Scholar
  46. Kalay E et al (2011) CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet 43:23–26PubMedCrossRefGoogle Scholar
  47. Kang JU, Koo SH, Kwon KC, Park JW, Kim JM (2008) Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer. Canc Genet Cytogenet 182:1–11CrossRefGoogle Scholar
  48. Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ (2000) Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J Cell Biol 150:975–988Google Scholar
  49. Keller LC, Romijn EP, Zamora I, Yates JR 3rd, Marshall WF (2005) Proteomic analysis of isolated Chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Curr Biol 15:1090–1098PubMedCrossRefGoogle Scholar
  50. Khodjakov A, Cole RW, Oakley BR, Rieder CL (2000) Centrosome-independent mitotic spindle formation in vertebrates. Curr Biol 10:59–67PubMedCrossRefGoogle Scholar
  51. Kim K, Rhee K (2011) The pericentriolar satellite protein CEP90 is crucial for integrity of the mitotic spindle pole. J Cell Sci 124:338–347Google Scholar
  52. Kim K, Lee S, Chang J, Rhee K (2008) A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization. Exp Cell Res 314:3692–3700PubMedCrossRefGoogle Scholar
  53. Kleylein-Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof YD, Nigg EA (2007) Plk4-induced centriole biogenesis in human cells. Dev Cell 13:190–202PubMedCrossRefGoogle Scholar
  54. Korvatska O et al (2011) Mutations in the TSGA14 gene in families with autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet 156B:303–311Google Scholar
  55. Kramer A et al (2003) Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin’s lymphoma. Leukemia 17:2207–2213PubMedCrossRefGoogle Scholar
  56. Kumar A, Purohit R (2012a) Computational investigation of pathogenic nsSNPs in CEP63 protein. Gene 503:75–82PubMedCrossRefGoogle Scholar
  57. Kumar A, Purohit R (2012b) Computational centrosomics: an approach to understand the dynamic behaviour of centrosome. Gene 511(1):125–126PubMedCrossRefGoogle Scholar
  58. Kumar A, Purohit R (2012c) Computational screening and molecular dynamics simulation of disease associated nsSNPs in CENP-E. Mutat Res 738–739:28–37. doi: 10.1016/j.mrfmmm.2012.08.005
  59. Kumar A et al (2012) Insight into Nek2A activity regulation and its pharmacological prospects. Egypt J Med Hum Genet. doi: 10.1016/j.ejmhg.2012.10.006
  60. Lahti JL et al (2012) Bioinformatics and variability in drug response: a protein structural perspective. J R Soc Interface 9:1409–1437PubMedCrossRefGoogle Scholar
  61. Lange BM (2002) Integration of the centrosome in cell cycle control, stress response and signal transduction pathways. Curr Opin Cell Biol 14:35–43PubMedCrossRefGoogle Scholar
  62. Leber B et al (2010) Proteins required for centrosome clustering in cancer cells. Sci Transl Med 2:33–38CrossRefGoogle Scholar
  63. Lee HH, Elia N, Ghirlando R, Lippincott-Schwartz J, Hurley JH (2008) Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science 322:576–580PubMedCrossRefGoogle Scholar
  64. Lee JE et al (2012) CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. Nat Genet 44:193–199Google Scholar
  65. Li JB et al (2004) Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 2004(117):541–552CrossRefGoogle Scholar
  66. Liska AJ, Popov AV, Sunyaev S, Coughlin P, Habermann B, Shevchenko A, Bork P, Karsenti E (2004) Homology-based functional proteomics by mass spectrometry: application to the Xenopus microtubule-associated proteome. Proteomics 4:2707–2721PubMedCrossRefGoogle Scholar
  67. Liu Q, Tan G, Levenkova N, Li T, Pugh EN Jr, Rux JJ, Speicher DW, Pierce EA (2007) The proteome of the mouse photoreceptor sensory cilium complex. Mol Cell Proteomics 6:1299–1317PubMedCrossRefGoogle Scholar
  68. Lizarraga SB et al (2010) Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development 137:1907–1917PubMedCrossRefGoogle Scholar
  69. Löffler H et al (2011) Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance. Cancer Res 71:2129–2139PubMedCrossRefGoogle Scholar
  70. Madeline AL et al (2011) Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome. Nat Med 17:726–731CrossRefGoogle Scholar
  71. Martinez-Garay I et al (2006) The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. Genomics 87:243–253PubMedCrossRefGoogle Scholar
  72. Megraw TL, Kao LR, Kaufman T (2001) Zygotic development without functional mitotic centrosomes. Curr Biol 11:116–120PubMedCrossRefGoogle Scholar
  73. Meraldi P, Nigg EA (2001) Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J Cell Sci 114:3749–3757PubMedGoogle Scholar
  74. Merchant SS et al (2007) The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science 2007(318):245–250CrossRefGoogle Scholar
  75. Müller H et al (2010) Proteomic and functional analysis of the mitotic Drosophila centrosome. EMBO J 2010(29):3344–3357CrossRefGoogle Scholar
  76. Neben K et al (2003) Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile. Blood 101:289–291PubMedCrossRefGoogle Scholar
  77. Nesslinger NJ et al (2007) Standard treatments induce antigen-specific immune responses in prostate cancer. Clin Cancer Res 13:1493–1502PubMedCrossRefGoogle Scholar
  78. Neumann B et al (2010) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464:721–727PubMedCrossRefGoogle Scholar
  79. Ohta T et al (2002) Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells. J Cell Biol 156:87–99PubMedCrossRefGoogle Scholar
  80. Oshimori N et al (2009) Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation. EMBO J 28:2066–2076Google Scholar
  81. Ostrowski LE, Blackburn K, Radde KM, Moyer MB, Schlatzer DM, Moseley A, Boucher RC (2002) A proteomic analysis of human cilia: identification of novel components. Mol Cell Proteomics 1:451–465PubMedCrossRefGoogle Scholar
  82. Ou YY, Mack GJ, Zhang M, Rattner JB (2002) CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. J Cell Sci 115(Pt 9):1825–1835PubMedGoogle Scholar
  83. Pazour GJ, Agrin N, Leszyk J, Witman GB (2005) Proteomic analysis of a eukaryotic cilium. J Cell Biol 170:103–113PubMedCrossRefGoogle Scholar
  84. Praetorius HA, Spring KR (2005) A physiological view of the primary cilium. Annu Rev Physiol 67:515–529PubMedCrossRefGoogle Scholar
  85. Quarmby LM, Parker JD (2005) Cilia and the cell cycle? J Cell Biol 169:707–710PubMedCrossRefGoogle Scholar
  86. Raff WJ (2001) Centrosomes: central no more? Curr Biol 11:R159–R161PubMedCrossRefGoogle Scholar
  87. Reinders Y, Schulz I, Graf R, Sickmann A (2006) Identification of novel centrosomal proteins in Dictyostelium discoideum by comparative proteomic approaches. J Proteome Res 5:589–598PubMedCrossRefGoogle Scholar
  88. Rellos P et al (2006) Structure and regulation of the human Nek2 centrosomal kinase. J Biol Chem 282:6833–6842PubMedCrossRefGoogle Scholar
  89. Rellos P et al (2007) Structure and regulation of the human Nek2 centrosomal kinase. J Biol Chem 282:6833–6842Google Scholar
  90. Sauer G, Korner R, Hanisch A, Ries A, Nigg EA, Sillje HH (2005) Proteome analysis of the human mitotic spindle. Mol Cell Proteomics 4:35–43PubMedGoogle Scholar
  91. Shiraishi T et al (2011) Cancer/testis antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy. J Transl Med 9:153PubMedCrossRefGoogle Scholar
  92. Sir JH et al (2011) A primary microcephaly protein complex forms a ring around parental centrioles. Nat Genet 43:1147–1153PubMedCrossRefGoogle Scholar
  93. Sivasubramaniam S et al (2008) Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev 22:587–600PubMedCrossRefGoogle Scholar
  94. Smith E, Dejsuphong D, Balestrini A (2009) An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol 11:278–285PubMedCrossRefGoogle Scholar
  95. Snape K et al (2011) Mutations in CEP57 cause mosaic variegated aneuploidy syndrome. Nat Genet 43:527–529PubMedCrossRefGoogle Scholar
  96. Solanki S et al (2011) Benzimidazole inhibitors induce a DFG-Out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure–activity relationship. J Med Chem 54:1626–1639PubMedCrossRefGoogle Scholar
  97. Spektor A et al (2007) Cep97 and CP110 suppress a cilia assembly program. Cell 130:678–690PubMedCrossRefGoogle Scholar
  98. Staples CJ et al (2012) The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci 125(Pt 20):4770–4779. doi: 10.1242/jcs.104059 PubMedCrossRefGoogle Scholar
  99. Stevens NR et al (2007) From stem cell to embryo without centrioles. Curr Biol 17:1498–1503PubMedCrossRefGoogle Scholar
  100. Tang GW, Altman RB (2011) Remote thioredoxin recognition using evolutionary conservation and structural dynamics. Structure 19:461–470PubMedCrossRefGoogle Scholar
  101. Tao et al (2012) A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. Carcinogenesis 33:598–603PubMedCrossRefGoogle Scholar
  102. Tomoda T et al (2012) Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. J Gastroenterol Hepatol 27:797–804PubMedCrossRefGoogle Scholar
  103. Tsang WY et al (2009) Cep76, a centrosomal protein that specifically restrains centriole reduplication. Dev Cell 16:649–660PubMedCrossRefGoogle Scholar
  104. Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G (2009) The augmin complex plays a critical role in spindle microtubule generation for mitotic progression andcytokinesis in human cells. Proc Natl Acad Sci USA 106:6998–7003Google Scholar
  105. van der Horst A, Khanna KK (2009) The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. Cancer Res 69:6651–6659PubMedCrossRefGoogle Scholar
  106. Wang Z et al (2010) Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. J Biol Chem 285:22658–22665PubMedCrossRefGoogle Scholar
  107. Wheatley DN, Wang AM, Strugnell GE (1996) Expression of primary cilia in mammalian cells. Cell Biol Int 20:73–81PubMedCrossRefGoogle Scholar
  108. Whelligan DK et al (2010) Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem 53:7682–7698PubMedCrossRefGoogle Scholar
  109. Wigge PA, Jensen ON, Holmes S, Soues S, Mann M, Kilmartin JV (1998) Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J Cell Biol 141:967–977PubMedCrossRefGoogle Scholar
  110. Wilkinson CJ, Carl M, Harris WA (2009) Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos. BMC Cell Biol 10:17PubMedCrossRefGoogle Scholar
  111. Woods CG, Bond J, Enard W (2005) Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings. Am J Hum Genet 76:717–728PubMedCrossRefGoogle Scholar
  112. Wu W et al (2007) Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase. J Biol Chem 282:26431–26440PubMedCrossRefGoogle Scholar
  113. Yu TW et al (2010) Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture. Nat Genet 42(11):1015–1020PubMedCrossRefGoogle Scholar
  114. Zhang X et al (2009) CDK5RAP2 is required for spindle checkpoint function. Cell Cycle 8:1206–1216PubMedCrossRefGoogle Scholar
  115. Zhao WM, Seki A, Fang G (2006) Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis. Mol Biol Cell 17:3881–3896PubMedCrossRefGoogle Scholar
  116. Zyss D, Gergely F (2009) Centrosome function in cancer: guilty or innocent? Trends Cell Biol 19:334–346PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Ambuj Kumar
    • 1
  • Vidya Rajendran
    • 1
  • Rao Sethumadhavan
    • 1
  • Rituraj Purohit
    • 1
    • 2
  1. 1.Bioinformatics Division, School of Bio Sciences and TechnologyVellore Institute of Technology UniversityVelloreIndia
  2. 2.Human Genetics Foundation—TorinoTurinItaly

Personalised recommendations