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Protoplasma

, Volume 248, Issue 4, pp 641–650 | Cite as

The apicoplast

  • Geoffrey Ian McFaddenEmail author
Review

Abstract

Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin. In this review, the discovery of the apicoplast and its integration, function and purpose are explored. New insights into the apicoplast fatty acid biosynthesis pathway and some novel roles of the apicoplast in vaccine development are reviewed.

Keywords

Apicoplast Endosymbiosis Malaria Plasmodium Plastid Toxoplasma 

Abbreviations

ER

Endoplasmic reticulum

ERAD

Endoplasmic reticulum-associated protein degradation

pPTs

Plastidic phosphate translocators

SELMA

Symbiont-specific ERAD-like machinery

Notes

Acknowledgements

GIM is an Australian Research Council Federation Fellow and a Howard Hughes International Research Scholar. Program Grant support from the National Health and Medical Research Council of Australia is gratefully acknowledged. The Australian Red Cross generously supplied human red blood cells for our research. I thank Giel van Dooren for suggestions on the manuscript and for pointing out the likely apicoplast ubiquitin.

Conflict of interest

The author declares that he has no conflict of interest.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.School of BotanyUniversity of MelbourneMelbourneAustralia

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