A Method for the Synthesis of 2,3-Disubstituted 2,3-Dihydrobenzofurans
The synthesis of 2,3-disubstituted 2,3-dihydrobenzofuran diastereomers is described. The key step in the reaction sequence is the chemoselective reduction of a tert. alcohole with tert.-butylamine-borane/AlCl3. The relative configuration of the substituents on the dihydrofurane moiety was assigned via NMR spectroscopy.
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