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Simple and sensitive electrochemical determination of higenamine in dietary supplements using a disposable pencil graphite electrode

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Abstract

In this study, a cheap, rapid, simple, and modification-free electroanalytical methodology based on the disposable pencil graphite electrode is described for the quantification of higenamine (isoquinoline-type alkaloid having three phenolic OHs). At first, the electrochemical oxidation of higenamine was investigated in aqueous solutions by cyclic voltammetry. The electrode process is pH-dependent and controlled by a mixture of diffusion and adsorption processes. Higenamine yielded two well-separated oxidation steps in acidic, neutral, and alkaline media by using square-wave voltammetry. By using the first oxidation peak due to its higher sensitivity, there was an excellent correlation between oxidation peak current at + 0.44 V and higenamine concentration (as hydrochloride salt) in the range of 0.05 to 2.0 μg cm−3 (1.63 × 10−7–6.5 × 10−6 mol dm−3), with a detection limit of 0.014 μg cm−3 (4.55 × 10−8 mol dm−3) in Britton–Robinson buffer at pH 4.0. As an example, the developed approach can be used for the quantification of higenamine in the commercial dietary supplement formulations.

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Correspondence to Yavuz Yardım or Zühre Şentürk.

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Pınar, P.T., Yardım, Y. & Şentürk, Z. Simple and sensitive electrochemical determination of higenamine in dietary supplements using a disposable pencil graphite electrode. Monatsh Chem (2020). https://doi.org/10.1007/s00706-020-02556-y

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Keywords

  • Higenamine
  • Pencil graphite electrode
  • Square-wave voltammetry
  • Dietary supplements