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Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 11, pp 1895–1902 | Cite as

Simple and rapid voltammetric determination of cephalosporin drug cefixime on boron-doped diamond electrode

  • Ertuğrul KeskinEmail author
  • Shabnam Allahverdiyeva
  • Hamza Seker
  • Yavuz Yardım
Original Paper
  • 38 Downloads

Abstract

A boron-doped diamond electrode was used for the first time in sensitive and selective analysis of cefixime, a third-generation cephalosporin drug, using the square-wave voltammetry technique. The effect of the pretreatment procedure on the current response at the electrode was investigated. The best signals were obtained by polishing the electrode with a polishing pad after applying anodic and cathodic electrochemical pretreatment to the electrode. Cefixime gave a well-defined, irreversible and diffusion-controlled oxidation peak in 0.1 mol dm−3 H2SO4 support electrolyte at + 1.25 V (vs. Ag/AgCl 3 mol dm−3 NaCl). Under the best instrumental conditions and with the pretreatment procedure, a calibration curve was obtained with linearity between 2.2 × 10−6 mol dm−3 and 1.3 × 10−4 mol dm−3 at 5.9 × 10−7 mol dm−3 detection limit. The effect of possible interference substances on the current response for cefixime was investigated and the method was found to have sufficient selectivity. The developed method was successfully applied for the analysis of cefixime from pharmaceutical formulations. The method can be an alternative to the other analytical approaches due to its speed, simplicity, low cost, wide calibration range, and repeatable responses.

Graphic abstract

Keywords

Cefixime Square-wave voltammetry Boron-doped diamond electrode Pretreatment procedures Pharmaceutical formulation 

Notes

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Analytical Chemistry, Faculty of PharmacyAdiyaman UniversityAdiyamanTurkey
  2. 2.Department of Biochemistry, Faculty of ScienceVan Yuzuncu Yil UniversityVanTurkey
  3. 3.Department of Analytical Chemistry, Faculty of PharmacyVan Yuzuncu Yil UniversityVanTurkey

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