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Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 11, pp 1973–1985 | Cite as

Substituted N-(thieno[2,3-b]pyridine-3-yl)acetamides: synthesis, reactions, and biological activity

  • Victor V. DotsenkoEmail author
  • Dmitrii S. Buryi
  • Darya Yu. Lukina
  • Angelica N. Stolyarova
  • Nicolai A. Aksenov
  • Inna V. Aksenova
  • Vladimir D. Strelkov
  • Lyudmila V. Dyadyuchenko
Original Paper
  • 115 Downloads

Abstract

A series of functionalized 3-(substituted amino)thieno[2,3-b]pyridines bearing azidoacetamide and monothiooxamide fragments have been prepared starting from readily available 2-chloro-N-(thieno[2,3-b]pyridine-3-yl)acetamides. Some of the compounds proved to be strong herbicide antidotes. The key structures were confirmed by X-ray diffraction and 2D NMR techniques.

Graphic abstract

Keywords

Acylation Combinatorial chemistry Azidoacetamides Monothiooxamides Biological activity Heterocycles 

Notes

Acknowledgements

This work was supported in part by the Russian Ministry of Education and Science (project 4.4892.2017/8.9) and Russian Foundation for Basic Research (project 19-43-230007 r_a). The study of herbicide antidote activity was performed in accordance with the State Assignment 075-00376-19-00 of the Russian Ministry of Education and Science, the research project 0686-2019-0013.

Supplementary material

706_2019_2505_MOESM1_ESM.pdf (4.6 mb)
Supplementary material 1 (PDF 4741 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Victor V. Dotsenko
    • 1
    • 2
    Email author
  • Dmitrii S. Buryi
    • 1
  • Darya Yu. Lukina
    • 1
  • Angelica N. Stolyarova
    • 1
  • Nicolai A. Aksenov
    • 2
  • Inna V. Aksenova
    • 2
  • Vladimir D. Strelkov
    • 1
    • 3
  • Lyudmila V. Dyadyuchenko
    • 3
  1. 1.Kuban State UniversityKrasnodarRussian Federation
  2. 2.North Caucasus Federal UniversityStavropolRussian Federation
  3. 3.Laboratory of Plant Growth RegulatorsAll-Russian Research Institute of Biological Plant ProtectionKrasnodarRussian Federation

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