Modular syntheses of 1,4,5-trisubstituted 1,2,3-triazoles by a one-pot three-step procedure: toward bio-inspired monomers
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Synthesis of 1,4,5-trisubstituted 1H-1,2,3-triazoles is reported by means of a transition metal-catalyzed arylation of 1-substituted-4-(2-bromoethyl)triazoles. The process which consists of one-pot three-step procedure allows a direct access to 1,5-disubstituted-4-(2-hydroxyethyl)triazoles and is suitable as an alternative methodology in the preparation of highly substituted triazoles in view of polymer chemistry.
Keywords1,2,3-Triazole Pd-catalyzed arylation Heck reaction Absorption click chemistry
This research was supported by the University of Toulon and did not receive any specific grant from other funding agencies (public, or private).
- 2.Omae I (2003) Chem Res 103:3431Google Scholar