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Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 4, pp 747–756 | Cite as

Synthesis of new 4-(1,2,3-triazolo)quinolin-2(1H)-ones via Cu-catalyzed [3 + 2] cycloaddition

  • Essmat M. El-Sheref
  • Ashraf A. AlyEmail author
  • Mohamed A. Ameen
  • Alan B. Brown
Original Paper
  • 38 Downloads

Abstract

In this investigation, new classes of 1,2,3-triazoles derived by 2-quinolone have been synthesized, via Cu-catalyzed [3 + 2] cycloadditions (Meldal-Sharpless ‘click’ reactions) of 4-azidoquinolin-2(1H)-ones with some alkynes. The structures of the products have been confirmed by different spectroscopic analyses.

Graphical abstract

Keywords

4-Azidoquinolin-2(1H)-ones Terminal alkynes 4-(1,2,3-triazolyl)quinolin-2(1H)-ones Click reaction Cycloaddition 

Notes

Acknowledgements

The NMR spectrometer at Florida Institute of Technology was purchased with assistance from the US National Science Foundation (CHE 03-42251).

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Essmat M. El-Sheref
    • 1
  • Ashraf A. Aly
    • 1
    Email author
  • Mohamed A. Ameen
    • 1
  • Alan B. Brown
    • 2
  1. 1.Chemistry Department, Faculty of ScienceMinia UniversityEl-MiniaArab Republic of Egypt
  2. 2.Chemistry DepartmentFlorida Institute of TechnologyMelbourneUSA

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