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Tandem synthesis of benzo[d]naphtho[2,3-g][1,3]oxazocine-8,13(6H,14H)-dione derivatives

  • Fatemeh Madani Qamsari
  • Shahram Moradi
  • Alireza Foroumadi
  • Mohammad Mahdavi
  • Abolghasem Moghimi
Original Paper
  • 13 Downloads

Abstract

An efficient and facile method for the synthesis of novel naphthooxazocines from 2-hydroxy-1,4-naphthoquinone and quinolinium salts at room temperature is described. The reaction proceeds through C-alkylation and intramolecular O-alkylation, affording the desired products in good yields.

Graphical abstract

Keywords

Naphthooxazocines Medium-sized heterocycle Intramolecular O-alkylation Tandem reaction 

Notes

Acknowledgements

This work was supported and funded by a grant from the research council of Tehran University of Medical Sciences (TUMS).

Supplementary material

706_2018_2322_MOESM1_ESM.docx (3.3 mb)
Supplementary material 1 (DOCX 3385 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of ChemistryTehran North Branch, Islamic Azad UniversityTehranIran
  2. 2.Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS)Tehran University of Medical SciencesTehranIran
  3. 3.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  4. 4.Department of ChemistryImam Hossein UniversityTehranIran

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