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Synthesis of a new series of benzo[d]imidazo[2,1-b]thiazole-1-ium hydroxides by a one-pot, three-component reaction in water

  • Nasser Etivand
  • Mehdi Ahmadi Sabegh
  • Jabbar KhalafyEmail author
Original Paper
  • 20 Downloads

Abstract

Herein, we report the green synthesis of a new series of benzo[d]imidazo[2,1-b]thiazole-1-ium hydroxide derivatives by a one-pot, three-component reaction of arylglyoxals, quinoline-2,4-diol, and 2-aminobenzothiazole in the presence of TEA/AcOH (1:2) as a catalyst at 50 °C in water, which appears as a green solvent. The structures of all 12 examples were confirmed by 1H NMR, 13C NMR, mass spectral data, and FT-IR. This procedure provides mild reaction conditions, using green solvent, high yields, easy work-up and simple isolation of structurally divers tricyclic benzo[d]imidazo[2,1-b]thiazole derivatives which may have biological and pharmaceutical activities.

Graphical abstract

Keywords

One-pot TCR Arylglyoxal monohydrates Quinoline-2,4-diol 2-Aminobenzothiazole Benzo[d]imidazo[2,1-b]thiazole-1-ium hydroxides 

Notes

Acknowledgements

The authors gratefully acknowledge the financial assistance from Urmia University.

Supplementary material

706_2018_2315_MOESM1_ESM.docx (4.7 mb)
Supplementary material 1 (DOCX 4823 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Organic Chemistry, Faculty of ChemistryUrmia UniversityUrmiaIran

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