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Synthesis, characterization, in vitro antimicrobial and QSAR studies of diorganotin(IV) complexes of Schiff bases derived from 2-(3-methylbutanoyl)-1H-indene-1,3(2H)-dione and 4-substituted anilines

  • Priyanka Khatkar
  • Sonika Asija
  • Aarti Ahlawat
  • Vikramjeet Singh
Original Paper
  • 12 Downloads

Abstract

A series of some new diorganotin(IV) complexes [R2SnLCl] was synthesized by the reaction of 2-(3-methylbutanoyl)-1H-indene-1,3(2H)-dione and 4-substituted anilines (p-OCH3, p-NO2, p-CH3, p-Cl) with R2SnCl2, (R=Me, Et, n-Bu, Ph) in 1:1 molar ratio. The structure of the Schiff bases and their complexes were characterized by IR, 13C, 1H, 119Sn NMR, and mass spectral techniques. The synthesized ligands and derived organotin complexes were evaluated in vitro against some bacterial strains, viz., Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus and fungal strains, viz., Aspergillus flavus, Aspergillus niger, and Candida albicans by serial dilution method. The antimicrobial results revealed that organotin complexes showed a distinct escalation in biocidal activity. Phenyl and butyl complexes were found to be more intoxicating. Furthermore, we performed QSAR studies which explained the different factors affecting the enhancement in the bioactivity of the complexes.

Graphical abstract

Keywords

Schiff bases Diorganotin(IV) complexes 2-(3-Methylbutanoyl)-1H-indene-1,3(2H)-dione Antibacterial activity Antifungal activity QSAR studies 

Supplementary material

706_2018_2308_MOESM1_ESM.docx (443 kb)
Supplementary material 1 (DOCX 443 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Priyanka Khatkar
    • 1
  • Sonika Asija
    • 1
  • Aarti Ahlawat
    • 1
  • Vikramjeet Singh
    • 2
  1. 1.Department of ChemistryGuru Jambheshwar University of Science and TechnologyHisarIndia
  2. 2.Department of Pharmaceutical SciencesGuru Jambheshwar University of Science and TechnologyHisarIndia

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