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Monatshefte für Chemie - Chemical Monthly

, Volume 146, Issue 10, pp 1699–1705 | Cite as

Synthesis and biological evaluation of 1,3,4-oxadiazole-linked bisindole derivatives as anticancer agents

  • Islavathu Hatti
  • Reddymasu Sreenivasulu
  • Surender Singh JadavEmail author
  • Mohamed Jawed AhsanEmail author
  • Rudraraju Ramesh RajuEmail author
Original Paper

Abstract

A series of ten 1,3,4-oxadiazole-linked bisindole derivatives have been synthesized. All compounds were evaluated for anticancer activity against four human cancer cell lines (MCF-7, KB, Colo-205, and A-549). Most of these new compounds exhibited significant anticancer activity as compared to etoposide. Compounds’ GI50 values range from <0.1 to 3.9 μM, while the positive control etoposide has a GI50 in the range of 0.13–3.08 μM in the cell lines employed. Among them, four compounds showed a higher activity than etoposide.

Graphical abstract

Keywords

Nortopsentins A-C Hamacanthin B Zibotentan (ZD4054) Bisindoles 1,3,4-Oxadiazoles Cytotoxicity 

Notes

Acknowledgments

We are grateful to CSIR-IICT, Hyderabad, for providing analytical facilities.

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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.Department of ChemistryAcharya Nagarjuna UniversityNagarjuna NagarIndia
  2. 2.Department of Pharmaceutical Sciences and TechnologyBirla Institute of TechnologyRanchiIndia
  3. 3.Department of Pharmaceutical ChemistryMaharishi Arvind College of PharmacyJaipurIndia

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