Monatshefte für Chemie - Chemical Monthly

, Volume 146, Issue 3, pp 441–447 | Cite as

Preparation and characterization of 5-fluorouracil surface-imprinted thermosensitive magnetic microspheres

Original Paper
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Abstract

5-Fluorouracil surface-imprinted thermosensitive magnetic microspheres were prepared by using Fe3O4-encapsulating carbon microspheres as cores, N-isopropylacrylamide as thermosentitive monomer, ammonium persulfate as initiator, N,N′-methylenebisacrylamide as crosslinker, and 5-fluorouracil as template molecule. The formation of these hybrid microspheres was verified by field emission scanning electron microscopy, transmission electron microscopy, Fourier transformation infrared spectroscopy, thermogravimetry, and dynamic light scattering. The results of the latter measurements show that the as-synthesized microspheres have a hydrodynamic diameter of 326 nm with the lower critical solution temperature of around 43 °C. The obtained microspheres are magnetic and show good potential for controlled loading and release of 5-fluorouracil.

Graphical abstract

Keywords

Fe3O4-encapsulating carbon microspheres Polymerization Magnetic Molecularly imprinted polymers Surface 
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Notes

Acknowledgments

The authors acknowledge financial support from National Natural Science Foundation of China (21176169), Shanxi Provincial Key Innovative Research Team in Science and Technology (2012041011), International Science & Technology Cooperation Program of China (2012DFR50460), and Research Project Supported by Shanxi Scholarship Council of China (2012-038).

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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  1. 1.Key Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyTaiyuanChina
  2. 2.Research Center on Advanced Materials Science and TechnologyTaiyuan University of TechnologyTaiyuanChina
  3. 3.College of Chemistry and Chemical EngineeringTaiyuan University of TechnologyTaiyuanChina

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