Monatshefte für Chemie - Chemical Monthly

, Volume 141, Issue 12, pp 1329–1332 | Cite as

A facile approach to substituted acrylates by regioselective and stereoselective addition of thiols and amines to an alkynyl ester in water

Original Paper
First Online:
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Accepted:

Abstract

Water-promoted hydrothiolation and hydroamination of ethyl propiolate leading to highly regioselective and stereoselective formation of thioacrylates and β-enamino esters in excellent yields, by a simple, efficient, and environmentally friendly reaction procedure without employing any hazardous reagent or solvent is reported.

Graphical Abstract

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Keywords

Water Hydrothiolation Hydroamination Thioacrylate β-Enamino ester 
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Notes

Acknowledgments

We acknowledge the financial support received from the National Institute of Pharmaceutical Education and Research.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Nitin A. Randive
    • 1
  • Varun Kumar
    • 1
  • Vipin A. Nair
    • 1
  1. 1.Department of Medicinal ChemistryNational Institute of Pharmaceutical Education and ResearchMohaliIndia

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