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Monatshefte für Chemie - Chemical Monthly

, Volume 141, Issue 12, pp 1339–1345 | Cite as

Nanocrystalline magnesium oxide: a novel and efficient catalyst for facile synthesis of 2,4,5-trisubstituted imidazole derivatives

  • Javad SafariEmail author
  • Shiva Dehghan Khalili
  • Mehran Rezaei
  • Sayed Hossein Banitaba
  • Fereshteh Meshkani
Original Paper

Abstract

Nanocrystalline magnesium oxide with high specific surface area has been used as a novel and efficient catalyst for an improved and rapid synthesis of biologically active 2,4,5-trisubstituted imidazoles, by three-component, one-pot condensation of 1,2-diketones and aryl aldehydes, in excellent yields under solvent-free and conventional heating conditions. The method has several advantages, for example excellent yields, shorter reaction time, and use of a non-toxic and recyclable catalyst.

Graphical abstract

Keywords

Nanocrystalline magnesium oxide 2,4,5-Trisubstituted imidazoles One-pot condensation Solvent-free conditions 

Notes

Acknowledgments

We gratefully acknowledge the financial support from the Research Council of the University of Kashan.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Javad Safari
    • 1
    Email author
  • Shiva Dehghan Khalili
    • 1
  • Mehran Rezaei
    • 2
  • Sayed Hossein Banitaba
    • 1
  • Fereshteh Meshkani
    • 2
  1. 1.Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of ChemistryUniversity of KashanKashanI.R. Iran
  2. 2.Catalyst and Advanced Materials Research Laboratory, Chemical Engineering Department, Faculty of EngineeringUniversity of KashanKashanI.R. Iran

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