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Highly efficient three-component, one-pot synthesis of dihydropyrano[3,2-c]chromene derivatives

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Abstract

An efficient and convenient method for synthesis of dihydropyrano[3,2-c]chromene derivatives by one-pot, three-component reaction of aldehydes, malononitrile, and 4-hydroxycoumarin in the presence of a catalytic amount of hexamethylenetetramine is reported. A variety of dihydropyrano[3,2-c]chromene derivatives were obtained in high to excellent yields within short times.

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Acknowledgments

We thank the National Natural Science Foundation of China (20872025), the Nature Science Foundation of Hebei Province (B2008000149), and the Research Foundation for the Graduate Program of Hebei Normal University for financial support.

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Authors and Affiliations

  1. The College of Chemistry and Material Science, Hebei Normal University, 050016, Shijiazhuang, China

    Hong-Juan Wang, Jie Lu & Zhan-Hui Zhang

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  1. Hong-Juan Wang
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  2. Jie Lu
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  3. Zhan-Hui Zhang
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Correspondence to Zhan-Hui Zhang.

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Wang, HJ., Lu, J. & Zhang, ZH. Highly efficient three-component, one-pot synthesis of dihydropyrano[3,2-c]chromene derivatives. Monatsh Chem 141, 1107–1112 (2010). https://doi.org/10.1007/s00706-010-0383-4

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  • DOI: https://doi.org/10.1007/s00706-010-0383-4

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