Monatshefte für Chemie - Chemical Monthly

, Volume 141, Issue 11, pp 1159–1182 | Cite as

Recent developments in benzotriazole methodology for construction of pharmacologically important heterocyclic skeletons

  • Raju R. Kale
  • Virendra Prasad
  • Prabhu P. Mohapatra
  • Vinod K. Tiwari


Benzotriazole methodology, nowadays recognized as a versatile, useful, and most successful synthesis protocol, has grown from an obscure level to very high popularity, since benzotriazole can easily be introduced into a molecule by a variety of reactions, activates it toward numerous transformations, is sufficiently stable during the course of reactions, and finally can easily be removed at the end of the reaction sequence. In this review, we briefly describe the way benzotriazole methodology has grown to its present height, the opportunities and its potentiality in the synthesis of diverse pharmacologically important heterocyclic skeletons.

Graphical abstract


Heterocycles Benzotriazole Cyclization Ylide 



Authors thank Department of Science and Technology, New Delhi, and University Grant Commission, New Delhi, India for the financial support. Authors are thankful to Dr. Robart D. Eagling, The Royal Society of Chemistry, UK, for his useful comments and Dr. Shashank Mishra, Institut de Recherche sur Catalyse, CNRS, Universite Lyon, France, for proofreading the manuscript.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Raju R. Kale
    • 1
  • Virendra Prasad
    • 1
  • Prabhu P. Mohapatra
    • 2
  • Vinod K. Tiwari
    • 1
  1. 1.Department of Chemistry, Centre of Advanced StudyBanaras Hindu UniversityVaranasiIndia
  2. 2.Reviva Pharmaceuticals Inc.San JoseUSA

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