Synthesis of imatinib: a convergent approach revisited
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- Ivanov, A.S. & Shishkov, S.V. Monatsh Chem (2009) 140: 619. doi:10.1007/s00706-008-0105-3
A classical convergent approach for the synthesis of the anticancer drug imatinib has been substantially improved. Imatinib was assembled by coupling the amine and carboxylic acid precursors by using N,N′-carbonyldiimidazole (CDI) as a condensing agent. Both intermediates have been synthesized by novel efficient methods.