Monatshefte für Chemie - Chemical Monthly

, Volume 140, Issue 6, pp 619–623

Synthesis of imatinib: a convergent approach revisited

Original Paper

DOI: 10.1007/s00706-008-0105-3

Cite this article as:
Ivanov, A.S. & Shishkov, S.V. Monatsh Chem (2009) 140: 619. doi:10.1007/s00706-008-0105-3


A classical convergent approach for the synthesis of the anticancer drug imatinib has been substantially improved. Imatinib was assembled by coupling the amine and carboxylic acid precursors by using N,N′-carbonyldiimidazole (CDI) as a condensing agent. Both intermediates have been synthesized by novel efficient methods.

Graphical abstract

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Imatinib Arylamine Carboxylic acid Amidation Reduction 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Pharm-SintezMoscowRussia

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